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Wdr91 WD repeat domain 91 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312225, updated on 25-Jan-2022

Summary

Official Symbol
Wdr91provided by RGD
Official Full Name
WD repeat domain 91provided by RGD
Primary source
RGD:1306697
See related
Ensembl:ENSRNOG00000010421 AllianceGenome:RGD:1306697
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306697
Summary
Predicted to enable phosphatidylinositol 3-kinase regulator activity. Predicted to be involved in early endosome to late endosome transport; regulation of cellular protein catabolic process; and regulation of phosphatidylinositol 3-kinase activity. Predicted to be located in cytosol. Predicted to be active in early endosome membrane and late endosome membrane. Predicted to be extrinsic component of endosome membrane. Orthologous to human WDR91 (WD repeat domain 91). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Kidney (RPKM 77.2), Thymus (RPKM 76.6) and 9 other tissues See more
Orthologs
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Genomic context

See Wdr91 in Genome Data Viewer
Location:
4q22
Exon count:
15
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (63554364..63591733, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (62398073..62438958, complement)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene AGBL carboxypeptidase 3 Neighboring gene transmembrane protein 140 Neighboring gene cell cycle regulator of NHEJ Neighboring gene stimulated by retinoic acid 8 Neighboring gene similar to Solute carrier family 23, member 2 (Sodium-dependent vitamin C transporter 2) Neighboring gene uncharacterized LOC103692099

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol 3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol 3-kinase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol 3-kinase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in extrinsic component of endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extrinsic component of endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extrinsic component of endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
WD repeat-containing protein 91

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127298.2NP_001120770.2  WD repeat-containing protein 91

    See identical proteins and their annotated locations for NP_001120770.2

    Status: VALIDATED

    Source sequence(s)
    AW919773, BC166785, EV771594
    UniProtKB/Swiss-Prot
    B2RYI0
    Related
    ENSRNOP00000014010.5, ENSRNOT00000014010.7
    Conserved Domains (2) summary
    sd00039
    Location:486557
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:407739
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    63554364..63591733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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