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Vps50 VPS50 subunit of EARP/GARPII complex [ Rattus norvegicus (Norway rat) ]

Gene ID: 312083, updated on 30-Jul-2025
Symbol
Vps50provided by RGD
Full Name
VPS50 subunit of EARP/GARPII complexprovided by RGD
Primary source
RGD:1304751
See related
Ensembl:ENSRNOG00000009894 AllianceGenome:RGD:1304751
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ccdc132; RGD1304751
Summary
Predicted to enable SNARE binding activity. Predicted to be involved in endocytic recycling. Located in membrane; perinuclear region of cytoplasm; and recycling endosome. Orthologous to human VPS50 (VPS50 subunit of EARP/GARPII complex). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Brain (RPKM 119.9), Kidney (RPKM 85.4) and 9 other tissues See more
Orthologs
human mouse all
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See Vps50 in Genome Data Viewer
Location:
4q13
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (32439101..32540299)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (31484424..31585617)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (28441255..28551784)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 9 like Neighboring gene HEPACAM family member 2 Neighboring gene calcitonin receptor Neighboring gene microRNA 653 Neighboring gene microRNA 489

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. A proposed clinical application of a model of CO2 laser radiation induced damage craters. Canestri F. J Med Eng Technol, 1988 May-Jun. PMID 3172165
  2. TSSC1 is novel component of the endosomal retrieval machinery. Gershlick DC, et al. Mol Biol Cell, 2016 Sep 15. PMID 27440922, Free PMC Article
  3. EARP is a multisubunit tethering complex involved in endocytic recycling. Schindler C, et al. Nat Cell Biol, 2015 May. PMID 25799061, Free PMC Article
  4. The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. Topalidou I, et al. PLoS Genet, 2016 May. PMID 27191843, Free PMC Article
  5. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding IEA
Inferred from Electronic Annotation
more info
  
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within endocytic recycling IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytic recycling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytic recycling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in retrograde transport, endosome to Golgi ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of EARP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of EARP complex IEA
Inferred from Electronic Annotation
more info
  
part_of EARP complex ISO
Inferred from Sequence Orthology
more info
  
part_of EARP complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
syndetin
Names
EARP/GARPII complex subunit VPS50
VPS50 EARP/GARPII complex subunit
coiled-coil domain containing 132
coiled-coil domain-containing protein 132
coiled-coil domain-containing protein 132-like
syndetin-like

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001173511.1 → NP_001166982.1  syndetin

    See identical proteins and their annotated locations for NP_001166982.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    F1LSG8
    UniProtKB/TrEMBL
    A0A8I6GK25
    Related
    ENSRNOP00000059003.1, ENSRNOT00000067087.4
    Conserved Domains (2) summary
    pfam10474
    Location:726 → 957
    DUF2451; Protein of unknown function C-terminus (DUF2451)
    pfam10475
    Location:54 → 345
    DUF2450; Protein of unknown function N-terminal domain (DUF2450)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    32439101..32540299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762704.4 → XP_008760926.1  syndetin isoform X1

    UniProtKB/TrEMBL
    A0A8I6GK25
    Conserved Domains (2) summary
    pfam10474
    Location:725 → 956
    DUF2451; Protein of unknown function C-terminus (DUF2451)
    pfam10475
    Location:54 → 345
    DUF2450; Protein of unknown function N-terminal domain (DUF2450)

  2. XM_006236037.5 → XP_006236099.1  syndetin isoform X2

    UniProtKB/TrEMBL
    A0A8I6GK25
    Conserved Domains (2) summary
    pfam10474
    Location:724 → 955
    DUF2451; Protein of unknown function C-terminus (DUF2451)
    pfam10475
    Location:54 → 343
    DUF2450; Protein of unknown function N-terminal domain (DUF2450)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1LSG8.1 GenPept UniProtKB/Swiss-Prot:F1LSG8

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