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Ptges2 prostaglandin E synthase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311865, updated on 21-Jul-2018

Summary

Official Symbol
Ptges2provided by RGD
Official Full Name
prostaglandin E synthase 2provided by RGD
Primary source
RGD:1310836
See related
Ensembl:ENSRNOG00000014050
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Heart (RPKM 172.7), Muscle (RPKM 165.4) and 9 other tissues See more
Orthologs

Genomic context

See Ptges2 in Genome Data Viewer
Location:
3p12
Exon count:
7
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11424195..11431379)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (16773065..16780249)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene CDKN1A interacting zinc finger protein 1 Neighboring gene similar to Hypothetical UPF0184 protein C9orf16 homolog Neighboring gene lipocalin 2 Neighboring gene solute carrier family 25 member 25 Neighboring gene nuclear apoptosis inducing factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
electron transfer activity IEA
Inferred from Electronic Annotation
more info
 
prostaglandin-E synthase activity IEA
Inferred from Electronic Annotation
more info
 
prostaglandin-E synthase activity ISO
Inferred from Sequence Orthology
more info
 
protein disulfide oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
electron transport chain IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
secretion IEA
Inferred from Electronic Annotation
more info
 
secretion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
prostaglandin E synthase 2
NP_001101302.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107832.1NP_001101302.1  prostaglandin E synthase 2

    See identical proteins and their annotated locations for NP_001101302.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474001
    UniProtKB/TrEMBL
    D4AE56
    Related
    ENSRNOP00000019184.4, ENSRNOT00000019184.6
    Conserved Domains (3) summary
    cd03197
    Location:223371
    GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2
    COG0625
    Location:101368
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03040
    Location:100176
    GST_N_mPGES2; GST_N family; microsomal Prostaglandin E synthase Type 2 (mPGES2) subfamily; mPGES2 is a membrane-anchored dimeric protein containing a CXXC motif which catalyzes the isomerization of PGH2 to PGE2. Unlike cytosolic PGE synthase (cPGES) and microsomal ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    11424195..11431379
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    10433385..10440575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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