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Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 311860, updated on 12-Aug-2018

Summary

Official Symbol
Abl1provided by RGD
Official Full Name
ABL proto-oncogene 1, non-receptor tyrosine kinaseprovided by RGD
Primary source
RGD:1584969
See related
Ensembl:ENSRNOG00000047356
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Abl
Expression
Biased expression in Kidney (RPKM 105.7), Lung (RPKM 94.8) and 9 other tissues See more
Orthologs

Genomic context

See Abl1 in Genome Data Viewer
Location:
3p12
Exon count:
12
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (10041820..10145076, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (15401182..15504438, complement)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene fibrinogen C domain containing 1-like 1 Neighboring gene pyroglutamylated RFamide peptide Neighboring gene exosome component 2 Neighboring gene PR/SET domain 12

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding ISO
Inferred from Sequence Orthology
more info
 
SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
actin filament binding ISO
Inferred from Sequence Orthology
more info
 
delta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity ISO
Inferred from Sequence Orthology
more info
 
magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
neuropilin binding ISO
Inferred from Sequence Orthology
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
proline-rich region binding ISO
Inferred from Sequence Orthology
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
syntaxin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
B cell proliferation involved in immune response ISO
Inferred from Sequence Orthology
more info
 
B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
B-1 B cell homeostasis ISO
Inferred from Sequence Orthology
more info
 
Bergmann glial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
DNA damage induced protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
actin filament branching ISO
Inferred from Sequence Orthology
more info
 
actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
activation of protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
alpha-beta T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
associative learning IEP
Inferred from Expression Pattern
more info
PubMed 
cardiovascular system development ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
cellular response to oxidative stress IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to transforming growth factor beta stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cerebellum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
collateral sprouting ISO
Inferred from Sequence Orthology
more info
 
endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
establishment of protein localization ISO
Inferred from Sequence Orthology
more info
 
glomerular visceral epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
microspike assembly ISO
Inferred from Sequence Orthology
more info
 
negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
neural tube closure ISO
Inferred from Sequence Orthology
more info
 
neuroepithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
neuromuscular process controlling balance ISO
Inferred from Sequence Orthology
more info
 
neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
neuropilin signaling pathway ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phagocytosis ISO
Inferred from Sequence Orthology
more info
 
platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
platelet-derived growth factor receptor-beta signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation blood vessel branching ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Wnt signaling pathway, planar cell polarity pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of actin filament binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of hydrogen peroxide-mediated programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interferon-gamma secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-2 secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of microtubule binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of osteoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-embryonic development ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of Cdc42 protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
regulation of T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
regulation of extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
 
regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
regulation of modification of synaptic structure IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of modification of synaptic structure ISO
Inferred from Sequence Orthology
more info
 
regulation of response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
response to epinephrine IEP
Inferred from Expression Pattern
more info
PubMed 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
signal transduction in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
spleen development ISO
Inferred from Sequence Orthology
more info
 
substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
thymus development ISO
Inferred from Sequence Orthology
more info
 
transitional one stage B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cell leading edge ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear body ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
ruffle IDA
Inferred from Direct Assay
more info
PubMed 
synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tyrosine-protein kinase ABL1
Names
Abelson murine leukemia viral (v-abl) oncogene homolog 1
c-abl oncogene 1, non-receptor tyrosine kinase
c-abl oncogene 1, receptor tyrosine kinase
v-abl Abelson murine leukemia viral oncogene 1
NP_001094320.1
XP_006233980.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100850.1NP_001094320.1  tyrosine-protein kinase ABL1

    See identical proteins and their annotated locations for NP_001094320.1

    Status: VALIDATED

    Source sequence(s)
    AABR07072853
    UniProtKB/TrEMBL
    E9PT20
    Related
    ENSRNOP00000044534.3, ENSRNOT00000042495.5
    Conserved Domains (5) summary
    smart00808
    Location:10191143
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:142235
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:84137
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:254516
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:261512
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    10041820..10145076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233918.3XP_006233980.1  tyrosine-protein kinase ABL1 isoform X1

    See identical proteins and their annotated locations for XP_006233980.1

    UniProtKB/TrEMBL
    D3ZGM3
    Conserved Domains (5) summary
    smart00808
    Location:10001124
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:123216
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:65118
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    cd05052
    Location:235497
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:242493
    Pkinase_Tyr; Protein tyrosine kinase

Alternate Rn_Celera

Genomic

  1. NW_001091907.1 Alternate Rn_Celera

    Range
    3639..4535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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