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Zer1 zyg-11 related, cell cycle regulator [ Rattus norvegicus (Norway rat) ]

Gene ID: 311842, updated on 10-Feb-2026
Official Symbol
Zer1provided by RGD
Official Full Name
zyg-11 related, cell cycle regulatorprovided by RGD
Primary source
RGD:1310284
See related
Ensembl:ENSRNOG00000025832 AllianceGenome:RGD:1310284
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zyg11bl; RGD1310284
Summary
Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein quality control for misfolded or incompletely synthesized proteins. Predicted to be part of Cul2-RING ubiquitin ligase complex. Orthologous to human ZER1 (zyg-11 related cell cycle regulator). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Brain (RPKM 171.9), Adrenal (RPKM 134.8) and 9 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Zer1 in Genome Data Viewer
Location:
3p12
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (33767520..33806716, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (13369688..13397524, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (8662579..8690486, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene Set nuclear proto-oncogene Neighboring gene protein kinase N3 Neighboring gene zDHHC palmitoyltransferase 12 Neighboring gene TBC1 domain family, member 13 Neighboring gene endonuclease G Neighboring gene SPOUT domain containing methyltransferase 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation. Timms RT, et al. Science, 2019 Jul 5. PMID 31273098, Free PMC Article
  2. The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components. Vasudevan S, et al. EMBO Rep, 2007 Mar. PMID 17304241, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein quality control for misfolded or incompletely synthesized proteins ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul2-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
protein zer-1 homolog
Names
zer-1 homolog

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100707.1 → NP_001094177.1  protein zer-1 homolog

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I5ZMI1, F1LQI6
    Related
    ENSRNOP00000032154.4, ENSRNOT00000035002.7
    Conserved Domains (3) summary
    cd00020
    Location:529 → 655
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:575 → 612
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    33767520..33806716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283936.1 → XP_063140006.1  protein zer-1 homolog isoform X2

    UniProtKB/TrEMBL
    A0ABK0LLN4
    Related
    ENSRNOP00000103879.1, ENSRNOT00000169293.1

  2. XM_063283935.1 → XP_063140005.1  protein zer-1 homolog isoform X1

    UniProtKB/TrEMBL
    A0ABK0LLN4

  3. XM_063283940.1 → XP_063140010.1  protein zer-1 homolog isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZMI1

  4. XM_063283938.1 → XP_063140008.1  protein zer-1 homolog isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZMI1, A0ABK0L569
    Related
    ENSRNOP00000099203.1, ENSRNOT00000126573.1

  5. XM_063283937.1 → XP_063140007.1  protein zer-1 homolog isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZMI1

  6. XM_008761657.4 → XP_008759879.1  protein zer-1 homolog isoform X10

    See identical proteins and their annotated locations for XP_008759879.1

    UniProtKB/TrEMBL
    A0A8I5ZMI1
    Conserved Domains (4) summary
    cd00020
    Location:516 → 642
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00033
    Location:281 → 324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:562 → 599
    ARM; armadillo repeat [structural motif]

  7. XM_008761656.4 → XP_008759878.1  protein zer-1 homolog isoform X10

    See identical proteins and their annotated locations for XP_008759878.1

    UniProtKB/TrEMBL
    A0A8I5ZMI1
    Conserved Domains (4) summary
    cd00020
    Location:516 → 642
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00033
    Location:281 → 324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:562 → 599
    ARM; armadillo repeat [structural motif]

  8. XM_039105229.2 → XP_038961157.1  protein zer-1 homolog isoform X12

    UniProtKB/TrEMBL
    A0A8I5ZMI1
    Conserved Domains (3) summary
    sd00033
    Location:281 → 324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:560 → 597
    ARM; armadillo repeat [structural motif]

  9. XM_017591838.2 → XP_017447327.1  protein zer-1 homolog isoform X11

    UniProtKB/TrEMBL
    A0A8I5ZMI1, A6JTV3
    Conserved Domains (4) summary
    cd00020
    Location:516 → 642
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00033
    Location:281 → 324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:562 → 599
    ARM; armadillo repeat [structural motif]

  10. XM_063283941.1 → XP_063140011.1  protein zer-1 homolog isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZMI1

  11. XM_017591837.2 → XP_017447326.2  protein zer-1 homolog isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZMI1

  12. XM_063283939.1 → XP_063140009.1  protein zer-1 homolog isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZMI1, A0A8I6AWN9
    Related
    ENSRNOP00000093181.2, ENSRNOT00000102789.2

  13. XM_008761655.4 → XP_008759877.1  protein zer-1 homolog isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZMI1
    Conserved Domains (4) summary
    cd00020
    Location:546 → 672
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00033
    Location:311 → 354
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:112 → 134
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:592 → 629
    ARM; armadillo repeat [structural motif]

  14. XM_017591839.3 → XP_017447328.1  protein zer-1 homolog isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZMI1
    Conserved Domains (4) summary
    cd00020
    Location:516 → 642
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00033
    Location:281 → 324
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:562 → 599
    ARM; armadillo repeat [structural motif]
Nucleotide Protein Strain
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