Nelfb negative elongation factor complex member B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nelfbprovided by RGD
Official Full Name: negative elongation factor complex member Bprovided by RGD
Primary source: RGD:1307832
See related: Ensembl:ENSRNOG00000009377 AllianceGenome:RGD:1307832
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cobra1; RGD1307832
Summary: Predicted to be involved in several processes, including negative regulation of stem cell differentiation; negative regulation of transcription elongation by RNA polymerase II; and stem cell differentiation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of NELF complex. Orthologous to human NELFB (negative elongation factor complex member B). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Adrenal (RPKM 120.6), Kidney (RPKM 116.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (28409045..28425564, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (8010883..8027403, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (2414448..2431148, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These studies allow us to position the actions of two new modulators of GR-regulated transactivation, NELF-A and NELF-B, relative to other factors in the overall gene induction sequence.
Title: A conserved protein motif is required for full modulatory activity of negative elongation factor subunits NELF-A and NELF-B in modifying glucocorticoid receptor-regulated gene induction properties.

Submit: New GeneRIF Correction

General gene information

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Markers

Cobra1 (e-PCR), detects polymorphism
- UniSTS:526749

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of stem cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in stem cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in stem cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NELF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NELF complex	IEA Inferred from Electronic Annotation more info
part_of NELF complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: negative elongation factor B

Names: cofactor of BRCA1; negative elongation factor protein B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107817.3 → NP_001101287.3 negative elongation factor B

Status: VALIDATED

Source sequence(s)

BC160853, JAXUCZ010000003

UniProtKB/TrEMBL

D4ACV0

Related

ENSRNOP00000012978.6, ENSRNOT00000012978.7

Conserved Domains (1) summary

pfam06209
Location:158 → 629

COBRA1; Cofactor of BRCA1 (COBRA1)