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Psd4 pleckstrin and Sec7 domain containing 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311785, updated on 3-Jun-2026
Official Symbol
Psd4provided by RGD
Official Full Name
pleckstrin and Sec7 domain containing 4provided by RGD
Primary source
RGD:1310289
See related
Ensembl:ENSRNOG00000006079 AllianceGenome:RGD:1310289
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and phospholipid binding activity. Predicted to be involved in regulation of ARF protein signal transduction. Predicted to be located in cell junction. Predicted to be active in ruffle membrane. Orthologous to human PSD4 (pleckstrin and Sec7 domain containing 4). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Thymus (RPKM 465.2), Spleen (RPKM 208.2) and 3 other tissues See more
Orthologs
all
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See Psd4 in Genome Data Viewer
Location:
3p13
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (27535341..27571850)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (7137069..7173571)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (1478432..1515094)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene interleukin 36, beta Neighboring gene interleukin 1 family member 10 Neighboring gene interleukin 1 receptor antagonist Neighboring gene uncharacterized LOC134486348 Neighboring gene paired box 8 Neighboring gene uncharacterized LOC102549381

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis. Ueda T, et al. FEBS Lett, 2013 Jun 5. PMID 23603394
  2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Clone Names

  • MGC124698

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
NOT located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
PH and SEC7 domain-containing protein 4

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134881.2 → NP_001128353.1  PH and SEC7 domain-containing protein 4

    See identical proteins and their annotated locations for NP_001128353.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    D3ZPP3
    Related
    ENSRNOP00000008161.3, ENSRNOT00000008161.6
    Conserved Domains (2) summary
    cd00171
    Location:536 → 690
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    cd13295
    Location:724 → 851
    PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

  2. NM_001434196.1 → NP_001421125.1  PH and SEC7 domain-containing protein 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    D3ZPP3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    27535341..27571850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006233592.5 → XP_006233654.1  PH and SEC7 domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006233654.1

    UniProtKB/TrEMBL
    D3ZPP3
    Conserved Domains (2) summary
    cd00171
    Location:536 → 690
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    cd13295
    Location:724 → 851
    PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

  2. XM_063283915.1 → XP_063139985.1  PH and SEC7 domain-containing protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A7Y6

  3. XM_039105177.2 → XP_038961105.1  PH and SEC7 domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    D3ZPP3
    Conserved Domains (2) summary
    cd00171
    Location:536 → 690
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    cd13295
    Location:724 → 851
    PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

  4. XM_039105178.2 → XP_038961106.1  PH and SEC7 domain-containing protein 4 isoform X1

    UniProtKB/TrEMBL
    D3ZPP3
    Conserved Domains (2) summary
    cd00171
    Location:536 → 690
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    cd13295
    Location:724 → 851
    PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

  5. XM_039105179.2 → XP_038961107.1  PH and SEC7 domain-containing protein 4 isoform X3

    Conserved Domains (2) summary
    cd00171
    Location:536 → 690
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    cl17171
    Location:724 → 859
    PH-like; Pleckstrin homology-like domain

  6. XM_039105180.1 → XP_038961108.1  PH and SEC7 domain-containing protein 4 isoform X4

    Conserved Domains (1) summary
    cl00136
    Location:536 → 628
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...

  7. XM_006233591.4 → XP_006233653.1  

    Conserved Domains (2) summary
    cd00171
    Location:536 → 690
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    cd13295
    Location:724 → 851
    PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain

  8. XM_006233593.5 → XP_006233655.1  PH and SEC7 domain-containing protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A7Y6
    Related
    ENSRNOP00000087791.1, ENSRNOT00000099515.2
    Conserved Domains (3) summary
    cd00171
    Location:533 → 687
    Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    cd13295
    Location:721 → 848
    PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
    pfam00169
    Location:743 → 840
    PH; PH domain

  9. XM_063283916.1 → XP_063139986.1  PH and SEC7 domain-containing protein 4 isoform X5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001037781.1: Suppressed sequence

    Description
    NM_001037781.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version

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