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Il36rn interleukin 36 receptor antagonist [ Rattus norvegicus (Norway rat) ]

Gene ID: 311783, updated on 5-Sep-2025
Official Symbol
Il36rnprovided by RGD
Official Full Name
interleukin 36 receptor antagonistprovided by RGD
Primary source
RGD:1311212
See related
Ensembl:ENSRNOG00000005751 AllianceGenome:RGD:1311212
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Il1f5
Summary
Predicted to enable cytokine activity and interleukin-1 receptor binding activity. Predicted to be involved in several processes, including antifungal humoral response; cellular response to lipopolysaccharide; and negative regulation of cytokine production. Predicted to act upstream of or within negative regulation of interleukin-6 production. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in pustular psoriasis 14. Orthologous to human IL36RN (interleukin 36 receptor antagonist). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Lung (RPKM 5.4), Liver (RPKM 3.2) and 4 other tissues See more
Orthologs
human mouse all
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See Il36rn in Genome Data Viewer
Location:
3p13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (27442679..27449306)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (7044419..7051016)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (1385256..1392275)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene interleukin 36, gamma Neighboring gene ribosomal protein L23a, pseudogene 10 Neighboring gene interleukin 36, alpha Neighboring gene interleukin 36, beta Neighboring gene interleukin 1 family member 10 Neighboring gene interleukin 1 receptor antagonist

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Deficiency of Interleukin-36 Receptor Protected Cardiomyocytes from Ischemia-Reperfusion Injury in Cardiopulmonary Bypass. Luo C, et al. Med Sci Monit, 2020 Feb 12. PMID 32048631, Free PMC Article
  2. The IL-36 receptor pathway regulates Aspergillus fumigatus-induced Th1 and Th17 responses. Gresnigt MS, et al. Eur J Immunol, 2013 Feb. PMID 23147407
  3. IL-36R ligands are potent regulators of dendritic and T cells. Vigne S, et al. Blood, 2011 Nov 24. PMID 21860022
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-1 receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antifungal humoral response IEA
Inferred from Electronic Annotation
more info
  
involved_in antifungal humoral response ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-17 production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of type II interferon production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
interleukin-36 receptor antagonist protein
Names
interleukin 1 family, member 5 (delta)
interleukin-1 family member 5

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107814.2 → NP_001101284.1  interleukin-36 receptor antagonist protein

    See identical proteins and their annotated locations for NP_001101284.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JSX9, D4A1A6
    Related
    ENSRNOP00000007593.4, ENSRNOT00000007593.6
    Conserved Domains (1) summary
    cl00094
    Location:10 → 153
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).

  2. NM_001434166.1 → NP_001421095.1  interleukin-36 receptor antagonist protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JSX9, D4A1A6

  3. NM_001434167.1 → NP_001421096.1  interleukin-36 receptor antagonist protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A6JSX9, D4A1A6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    27442679..27449306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283914.1 → XP_063139984.1  interleukin-36 receptor antagonist protein isoform X1

  2. XM_039105176.2 → XP_038961104.1  interleukin-36 receptor antagonist protein isoform X1

    Conserved Domains (1) summary
    cl00094
    Location:10 → 153
    IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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