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Chd6 chromodomain helicase DNA binding protein 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311607, updated on 3-Jun-2026
Official Symbol
Chd6provided by RGD
Official Full Name
chromodomain helicase DNA binding protein 6provided by RGD
Primary source
RGD:1310465
See related
Ensembl:ENSRNOG00000016744 AllianceGenome:RGD:1310465
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CHD-6
Summary
Predicted to enable several functions, including ATP hydrolysis activity; ATP-dependent chromatin remodeler activity; and transcription coregulator binding activity. Predicted to be involved in cell redox homeostasis; chromatin remodeling; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in chromatin and nucleus. Orthologous to human CHD6 (chromodomain helicase DNA binding protein 6). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Thymus (RPKM 176.4), Kidney (RPKM 121.6) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Chd6 in Genome Data Viewer
Location:
3q42
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (170016204..170177480, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (149596509..149757765, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (156937746..157099328, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene zinc fingers and homeoboxes 3 Neighboring gene uncharacterized LOC134486198 Neighboring gene lipin 3 Neighboring gene elastin microfibril interfacer 3 Neighboring gene uncharacterized LOC134486200 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC108350515 Neighboring gene uncharacterized LOC120101777

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. CHD6 is a DNA-dependent ATPase and localizes at nuclear sites of mRNA synthesis. Lutz T, et al. FEBS Lett, 2006 Oct 30. PMID 17027977
  2. The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation. Nioi P, et al. Mol Cell Biol, 2005 Dec. PMID 16314513, Free PMC Article
  3. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD, et al. Trends Biochem Sci, 2014 Apr. PMID 24647116
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP hydrolysis activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP-dependent activity, acting on DNA ISO
Inferred from Sequence Orthology
more info
  
enables ATP-dependent activity, acting on DNA ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP-dependent chromatin remodeler activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell redox homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
ATP-dependent chromatin remodeler CHD6; chromodomain-helicase-DNA-binding protein 6
Names
ATP-dependent helicase CHD6
chromo domain-containing protein 6
NP_001101267.1
XP_006235546.2
XP_008760567.1
XP_008760568.1
XP_017447279.2
XP_038961032.1
XP_038961033.1
XP_038961034.1
XP_038961035.1
XP_038961036.1
XP_038961037.1
XP_038961039.1
XP_038961040.1
XP_038961041.1
XP_038961042.1
XP_038961043.1
XP_038961044.1
XP_063139932.1
XP_063139933.1
XP_063139934.1
XP_063139935.1
XP_063139936.1
XP_063139937.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107797.2 → NP_001101267.1  ATP-dependent chromatin remodeler CHD6 isoform 2

    See identical proteins and their annotated locations for NP_001101267.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    D3ZA12
    UniProtKB/TrEMBL
    A0A8I5Y6Q9
    Conserved Domains (5) summary
    cd00046
    Location:479 → 628
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:463 → 750
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:782 → 896
    Helicase_C; Helicase conserved C-terminal domain
    pfam00385
    Location:375 → 428
    Chromo; Chromo (CHRromatin Organization MOdifier) domain
    cl00146
    Location:104 → 257
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

  2. NM_001434092.1 → NP_001421021.1  ATP-dependent chromatin remodeler CHD6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I5Y6Q9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    170016204..170177480 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105105.2 → XP_038961033.1  

    Conserved Domains (5) summary
    PTZ00449
    Location:100 → 372
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PLN03142
    Location:458 → 983
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd18663
    Location:371 → 429
    CD2_tandem_CHD5-9_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
    cd18668
    Location:287 → 352
    CD1_tandem_CHD5-9_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
    cl28899
    Location:459 → 680
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  2. XM_017591790.3 → XP_017447279.2  chromodomain-helicase-DNA-binding protein 6 isoform X4

    UniProtKB/TrEMBL
    A0A8I5Y6Q9
    Conserved Domains (5) summary
    PTZ00449
    Location:100 → 372
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PLN03142
    Location:459 → 984
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd18663
    Location:371 → 429
    CD2_tandem_CHD5-9_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
    cd18668
    Location:287 → 352
    CD1_tandem_CHD5-9_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
    cl28899
    Location:460 → 681
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  3. XM_006235484.5 → XP_006235546.2  chromodomain-helicase-DNA-binding protein 6 isoform X6

    UniProtKB/TrEMBL
    A0A8I5Y6Q9, A0A8I6AKM1
    Related
    ENSRNOP00000093958.2, ENSRNOT00000106235.2
    Conserved Domains (5) summary
    PTZ00449
    Location:100 → 372
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PLN03142
    Location:459 → 984
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd18663
    Location:371 → 429
    CD2_tandem_CHD5-9_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
    cd18668
    Location:287 → 352
    CD1_tandem_CHD5-9_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
    cl28899
    Location:460 → 681
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  4. XM_039105107.2 → XP_038961035.1  chromodomain-helicase-DNA-binding protein 6 isoform X8

    UniProtKB/TrEMBL
    A0A8I5Y6Q9
    Conserved Domains (5) summary
    PTZ00449
    Location:100 → 372
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PLN03142
    Location:459 → 984
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd18663
    Location:371 → 429
    CD2_tandem_CHD5-9_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
    cd18668
    Location:287 → 352
    CD1_tandem_CHD5-9_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
    cl28899
    Location:460 → 681
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  5. XM_039105106.2 → XP_038961034.1  chromodomain-helicase-DNA-binding protein 6 isoform X7

    UniProtKB/TrEMBL
    A0A0G2K1L7, A0A8I5Y6Q9
    Related
    ENSRNOP00000071893.2, ENSRNOT00000089958.3
    Conserved Domains (5) summary
    PTZ00449
    Location:100 → 372
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PLN03142
    Location:459 → 984
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd18663
    Location:371 → 429
    CD2_tandem_CHD5-9_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
    cd18668
    Location:287 → 352
    CD1_tandem_CHD5-9_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
    cl28899
    Location:460 → 681
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  6. XM_008762345.4 → XP_008760567.1  chromodomain-helicase-DNA-binding protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y6Q9, A0A8L2QC41
    Related
    ENSRNOP00000022861.7, ENSRNOT00000022861.8
    Conserved Domains (5) summary
    PTZ00449
    Location:100 → 372
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PLN03142
    Location:459 → 984
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd18663
    Location:371 → 429
    CD2_tandem_CHD5-9_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
    cd18668
    Location:287 → 352
    CD1_tandem_CHD5-9_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
    cl28899
    Location:460 → 681
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  7. XM_063283862.1 → XP_063139932.1  chromodomain-helicase-DNA-binding protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y6Q9, A0A8L2QC41

  8. XM_063283864.1 → XP_063139934.1  chromodomain-helicase-DNA-binding protein 6 isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y6Q9, A0A8I6ARM3
    Related
    ENSRNOP00000094454.2, ENSRNOT00000107966.2

  9. XM_008762346.4 → XP_008760568.1  chromodomain-helicase-DNA-binding protein 6 isoform X5

    UniProtKB/TrEMBL
    A0A8I5Y6Q9
    Related
    ENSRNOP00000076519.1, ENSRNOT00000119650.2
    Conserved Domains (5) summary
    cd00046
    Location:457 → 606
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:441 → 728
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:760 → 874
    Helicase_C; Helicase conserved C-terminal domain
    pfam00385
    Location:353 → 406
    Chromo; Chromo (CHRromatin Organization MOdifier) domain
    cl00146
    Location:82 → 235
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

  10. XM_063283863.1 → XP_063139933.1  chromodomain-helicase-DNA-binding protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y6Q9, A0A8L2QC41

  11. XM_039105104.2 → XP_038961032.1  chromodomain-helicase-DNA-binding protein 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y6Q9, A0A8L2QC41
    Conserved Domains (5) summary
    PTZ00449
    Location:100 → 372
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PLN03142
    Location:459 → 984
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd18663
    Location:371 → 429
    CD2_tandem_CHD5-9_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
    cd18668
    Location:287 → 352
    CD1_tandem_CHD5-9_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
    cl28899
    Location:460 → 681
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  12. XM_063283865.1 → XP_063139935.1  chromodomain-helicase-DNA-binding protein 6 isoform X10

    UniProtKB/TrEMBL
    A0A8I5Y6Q9

  13. XM_039105108.2 → XP_038961036.1  chromodomain-helicase-DNA-binding protein 6 isoform X9

    UniProtKB/TrEMBL
    A0A8I5Y6Q9, A0A8I6A6R3
    Related
    ENSRNOP00000086889.1, ENSRNOT00000114568.2
    Conserved Domains (4) summary
    PLN03142
    Location:211 → 736
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd18663
    Location:123 → 181
    CD2_tandem_CHD5-9_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
    cd18668
    Location:39 → 104
    CD1_tandem_CHD5-9_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
    cl28899
    Location:212 → 433
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  14. XM_039105111.2 → XP_038961039.1  chromodomain-helicase-DNA-binding protein 6 isoform X14

  15. XM_039105112.2 → XP_038961040.1  chromodomain-helicase-DNA-binding protein 6 isoform X15

  16. XM_039105113.2 → XP_038961041.1  chromodomain-helicase-DNA-binding protein 6 isoform X16

  17. XM_039105116.2 → XP_038961044.1  chromodomain-helicase-DNA-binding protein 6 isoform X19

  18. XM_039105109.2 → XP_038961037.1  chromodomain-helicase-DNA-binding protein 6 isoform X12

    Conserved Domains (5) summary
    PTZ00449
    Location:81 → 372
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PLN03142
    Location:459 → 984
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd18663
    Location:371 → 429
    CD2_tandem_CHD5-9_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
    cd18668
    Location:287 → 352
    CD1_tandem_CHD5-9_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
    cl28899
    Location:460 → 681
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  19. XM_063283867.1 → XP_063139937.1  chromodomain-helicase-DNA-binding protein 6 isoform X13

  20. XM_063283866.1 → XP_063139936.1  chromodomain-helicase-DNA-binding protein 6 isoform X11

  21. XM_039105115.2 → XP_038961043.1  chromodomain-helicase-DNA-binding protein 6 isoform X17

    Conserved Domains (5) summary
    PTZ00449
    Location:100 → 372
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PLN03142
    Location:459 → 984
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd18663
    Location:371 → 429
    CD2_tandem_CHD5-9_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
    cd18668
    Location:287 → 352
    CD1_tandem_CHD5-9_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
    cl28899
    Location:460 → 681
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

  22. XM_039105114.2 → XP_038961042.1  chromodomain-helicase-DNA-binding protein 6 isoform X18

    Conserved Domains (5) summary
    PTZ00449
    Location:100 → 372
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PLN03142
    Location:459 → 984
    PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional
    cd18663
    Location:371 → 429
    CD2_tandem_CHD5-9_like; repeat 2 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
    cd18668
    Location:287 → 352
    CD1_tandem_CHD5-9_like; repeat 1 of the paired tandem chromodomains of chromodomain helicase DNA-binding protein 5-9, and similar proteins
    cl28899
    Location:460 → 681
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

RNA

  1. XR_005501897.2 RNA Sequence

  2. XR_005501896.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZA12.2 GenPept UniProtKB/Swiss-Prot:D3ZA12

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