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Pax1 paired box 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311505, updated on 24-Apr-2022

Summary

Official Symbol
Pax1provided by RGD
Official Full Name
paired box 1provided by RGD
Primary source
RGD:1588548
See related
Ensembl:ENSRNOG00000024882 AllianceGenome:RGD:1588548
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pax-1
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure development and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including animal organ development; positive regulation of transcription by RNA polymerase II; and somitogenesis. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in branchiootorenal syndrome. Orthologous to human PAX1 (paired box 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 54.5) See more
Orthologs
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Genomic context

See Pax1 in Genome Data Viewer
Location:
3q41
Exon count:
6
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (134789291..134801636)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (141577124..141589849)

Chromosome 3 - NC_051338.1Genomic Context describing neighboring genes Neighboring gene NK2 homeobox 2 Neighboring gene uncharacterized LOC108350489 Neighboring gene uncharacterized LOC108350490 Neighboring gene similar to Alpha-enolase (2-phospho-D-glycerate hydro-lyase) (Non-neural enolase) (NNE) (Enolase 1)

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within CD4-positive, alpha-beta T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within CD8-positive, alpha-beta T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within bone morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within parathyroid gland development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pattern specification process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within sclerotome development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skeletal system development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within somitogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within thymus development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
paired box protein Pax-1
Names
Paired box homeotic gene 1
paired box gene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401899.1NP_001388828.1  paired box protein Pax-1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000119

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051338.1 Reference mRatBN7.2 Primary Assembly

    Range
    134789291..134801636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105048.1XP_038960976.1  paired box protein Pax-1 isoform X1

    Related
    ENSRNOP00000096757.1, ENSRNOT00000103021.1
    Conserved Domains (1) summary
    cd00131
    Location:90217
    PAX; Paired Box domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107787.1: Suppressed sequence

    Description
    NM_001107787.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.