Dll4 delta like canonical Notch ligand 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dll4provided by RGD
Official Full Name: delta like canonical Notch ligand 4provided by RGD
Primary source: RGD:1309740
See related: Ensembl:ENSRNOG00000014011
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression: Biased expression in Lung (RPKM 143.2), Heart (RPKM 59.0) and 7 other tissues See more
Orthologs: human mouse all

Genomic context

Location:: 3q35

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (111135011..111146746)
104	previous assembly	Rnor_5.0 (GCF_000001895.4)	3	NC_005102.3 (117685724..117695772)

Chromosome 3 - NC_005102.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Down-regulation of DLL4 expression is involved in chondrogenic differentiation of mesenchymal stem cells.
Title: MicroRNA-30a promotes chondrogenic differentiation of mesenchymal stem cells through inhibiting Delta-like 4 expression.
DLL4 expression increased in ischemic tissues and DLL4 expression was upregulated in capillary endothelial cells after ischemia.
Title: Inhibition of the Notch Pathway Promotes Flap Survival by Inducing Functional Neoangiogenesis.
The 2.3 angstrom resolution crystal structure of the interacting regions of the Notch1-DLL4 complex reveals a two-site, antiparallel binding orientation assisted by Notch1 O-linked glycosylation.
Title: Structural biology. Structural basis for Notch1 engagement of Delta-like 4.
Data suggest that DLL4, NOTCH1, and NOTCH4 are expressed in nuclei of small/large luteal cells of corpora lutea (CL) from pregnant rats and that luteolytic hormone PGF2alpha decreases the CL mRNA and protein expression of these NOTCH family members.
Title: Role of the DLL4-NOTCH system in PGF2alpha-induced luteolysis in the pregnant rat.

Submit: New GeneRIF Correction

Variation

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Pathways from BioSystems

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Breast cancer, organism-specific biosystem (from KEGG)
Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
Breast cancer, conserved biosystem (from KEGG)
Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
Endocrine resistance, organism-specific biosystem (from KEGG)
Endocrine resistance, organism-specific biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
Endocrine resistance, conserved biosystem (from KEGG)
Endocrine resistance, conserved biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
NOTCH2 Activation and Transmission of Signal to the Nucleus, organism-specific biosystem (from REACTOME)
NOTCH2 Activation and Transmission of Signal to the Nucleus, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
Notch Signaling Pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
Notch signaling, organism-specific biosystem (from KEGG)
Notch signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
Notch signaling, conserved biosystem (from KEGG)
Notch signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
Notch signaling pathway, organism-specific biosystem (from KEGG)
Notch signaling pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
Notch signaling pathway, conserved biosystem (from KEGG)
Notch signaling pathway, conserved biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by NOTCH, organism-specific biosystem (from REACTOME)
Signaling by NOTCH, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by NOTCH2, organism-specific biosystem (from REACTOME)
Signaling by NOTCH2, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by NOTCH3, organism-specific biosystem (from REACTOME)
Signaling by NOTCH3, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by NOTCH4, organism-specific biosystem (from REACTOME)
Signaling by NOTCH4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Th1 and Th2 cell differentiation, organism-specific biosystem (from KEGG)
Th1 and Th2 cell differentiation, organism-specific biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
Th1 and Th2 cell differentiation, conserved biosystem (from KEGG)
Th1 and Th2 cell differentiation, conserved biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:465450 (e-PCR)
- UniSTS:465450

Dll4 (e-PCR), detects polymorphism
- UniSTS:465450

UniSTS:465451 (e-PCR)
- UniSTS:465451

Dll4 (e-PCR), detects polymorphism
- UniSTS:465451

d3mgh11 (e-PCR)
- UniSTS:120408

Homology

Homologs of the Dll4 gene: The Dll4 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 249 organisms have orthologs with human gene Dll4
Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
Notch binding	IEA Inferred from Electronic Annotation more info
Notch binding	ISO Inferred from Sequence Orthology more info
calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
Notch signaling involved in heart development	IEA Inferred from Electronic Annotation more info
Notch signaling involved in heart development	ISO Inferred from Sequence Orthology more info
Notch signaling pathway	ISO Inferred from Sequence Orthology more info
T cell differentiation	IEA Inferred from Electronic Annotation more info
T cell differentiation	ISO Inferred from Sequence Orthology more info
angiogenesis	ISO Inferred from Sequence Orthology more info
blood vessel lumenization	IEA Inferred from Electronic Annotation more info
blood vessel lumenization	ISO Inferred from Sequence Orthology more info
blood vessel remodeling	IEA Inferred from Electronic Annotation more info
blood vessel remodeling	ISO Inferred from Sequence Orthology more info
branching involved in blood vessel morphogenesis	IEA Inferred from Electronic Annotation more info
branching involved in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
cardiac atrium morphogenesis	IEA Inferred from Electronic Annotation more info
cardiac atrium morphogenesis	ISO Inferred from Sequence Orthology more info
cardiac ventricle morphogenesis	ISO Inferred from Sequence Orthology more info
cellular response to fibroblast growth factor stimulus	ISO Inferred from Sequence Orthology more info
cellular response to vascular endothelial growth factor stimulus	ISO Inferred from Sequence Orthology more info
dorsal aorta morphogenesis	IEA Inferred from Electronic Annotation more info
dorsal aorta morphogenesis	ISO Inferred from Sequence Orthology more info
negative regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
negative regulation of blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
negative regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
negative regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
negative regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
negative regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
pericardium morphogenesis	IEA Inferred from Electronic Annotation more info
pericardium morphogenesis	ISO Inferred from Sequence Orthology more info
positive regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
positive regulation of neural precursor cell proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
regulation of neural retina development	IEA Inferred from Electronic Annotation more info
regulation of neural retina development	ISO Inferred from Sequence Orthology more info
regulation of neurogenesis	IEA Inferred from Electronic Annotation more info
regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
ventral spinal cord interneuron fate commitment	ISO Inferred from Sequence Orthology more info
ventricular trabecula myocardium morphogenesis	IEA Inferred from Electronic Annotation more info
ventricular trabecula myocardium morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
integral component of membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: delta-like protein 4

Names: delta-like 4; delta4; drosophila Delta homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107760.1 → NP_001101230.1 delta-like protein 4 precursor

See identical proteins and their annotated locations for NP_001101230.1

Status: PROVISIONAL

Source sequence(s)

CH473949

Conserved Domains (3) summary

cd00054
Location:328 → 360

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam01414
Location:155 → 217

DSL; Delta serrate ligand

pfam07657
Location:27 → 88

MNNL; N terminus of Notch ligand

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

NC_005102.4 Reference Rnor_6.0 Primary Assembly

Range

111135011..111146746

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006234765.2 → XP_006234827.1 delta-like protein 4 isoform X1

UniProtKB/Swiss-Prot

D3ZHH1

Related

ENSRNOP00000018970.6, ENSRNOT00000018970.6

Conserved Domains (3) summary

cd00054
Location:329 → 361

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam01414
Location:156 → 218

DSL; Delta serrate ligand

pfam07657
Location:28 → 89

MNNL; N terminus of Notch ligand