U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dll4 delta like canonical Notch ligand 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311332, updated on 11-Jun-2025
Official Symbol
Dll4provided by RGD
Official Full Name
delta like canonical Notch ligand 4provided by RGD
Primary source
RGD:1309740
See related
Ensembl:ENSRNOG00000014011 AllianceGenome:RGD:1309740
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable Notch binding activity and receptor ligand activity. Involved in several processes, including cellular response to cholesterol; chondrocyte differentiation; and luteolysis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Biomarker of diabetes mellitus; ischemia (multiple); lung carcinoma (multiple); polycystic kidney disease; and retinopathy of prematurity. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and limb ischemia. Orthologous to human DLL4 (delta like canonical Notch ligand 4). [provided by Alliance of Genome Resources, Jun 2025]
Expression
Biased expression in Lung (RPKM 143.2), Heart (RPKM 59.0) and 7 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See Dll4 in Genome Data Viewer
Location:
3q35
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (126770945..126780769)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (106317114..106327004)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (111135011..111146746)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 603 Neighboring gene VPS18 core subunit of CORVET and HOPS complexes Neighboring gene delta like canonical Notch ligand 4 like 1 Neighboring gene ChaC glutathione-specific gamma-glutamylcyclotransferase 1 Neighboring gene INO80 complex ATPase subunit

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Notch binding IEA
Inferred from Electronic Annotation
more info
 
enables Notch binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables receptor ligand activity IEA
Inferred from Electronic Annotation
more info
 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
 
involved_in aortic valve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in aortic valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in blood vessel lumenization IEA
Inferred from Electronic Annotation
more info
 
involved_in blood vessel lumenization ISO
Inferred from Sequence Orthology
more info
 
involved_in blood vessel remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in blood vessel remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in branching involved in blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in branching involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac atrium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac atrium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac ventricle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac ventricle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell communication IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cholesterol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to fibroblast growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to fibroblast growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in chondrocyte differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in dorsal aorta morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in dorsal aorta morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in luteolysis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration involved in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in pericardium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in pericardium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neural retina development IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of neural retina development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of neurogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in system development IEA
Inferred from Electronic Annotation
more info
 
involved_in tissue development IEA
Inferred from Electronic Annotation
more info
 
involved_in ventral spinal cord interneuron fate commitment IEA
Inferred from Electronic Annotation
more info
 
involved_in ventral spinal cord interneuron fate commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular trabecula myocardium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in ventricular trabecula myocardium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
delta-like protein 4
Names
delta-like 4
delta4
drosophila Delta homolog 4

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107760.2NP_001101230.1  delta-like protein 4 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001101230.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8L2Q9H8, A6HPF0
    Conserved Domains (3) summary
    cd00054
    Location:328360
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01414
    Location:155217
    DSL; Delta serrate ligand
    pfam07657
    Location:2788
    MNNL; N terminus of Notch ligand
  2. NM_001431709.1NP_001418638.1  delta-like protein 4 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    D3ZHH1
    UniProtKB/TrEMBL
    A0A8L2Q9H8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    126770945..126780769
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234765.4XP_006234827.1  delta-like protein 4 isoform X1

    Related
    ENSRNOP00000091766.1, ENSRNOT00000117478.2
    Conserved Domains (3) summary
    cd00054
    Location:329361
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01414
    Location:156218
    DSL; Delta serrate ligand
    pfam07657
    Location:2889
    MNNL; N terminus of Notch ligand