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Dll4 delta like canonical Notch ligand 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311332, updated on 2-Oct-2018

Summary

Official Symbol
Dll4provided by RGD
Official Full Name
delta like canonical Notch ligand 4provided by RGD
Primary source
RGD:1309740
See related
Ensembl:ENSRNOG00000014011
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Lung (RPKM 143.2), Heart (RPKM 59.0) and 7 other tissues See more
Orthologs

Genomic context

See Dll4 in Genome Data Viewer
Location:
3q35
Exon count:
11
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (111135011..111146746)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (117685724..117695772)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene VPS18 CORVET/HOPS core subunit Neighboring gene uncharacterized LOC103691871 Neighboring gene ChaC glutathione-specific gamma-glutamylcyclotransferase 1 Neighboring gene INO80 complex subunit

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from BioSystems

  • Breast cancer, organism-specific biosystem (from KEGG)
    Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Breast cancer, conserved biosystem (from KEGG)
    Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
  • Endocrine resistance, organism-specific biosystem (from KEGG)
    Endocrine resistance, organism-specific biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
  • Endocrine resistance, conserved biosystem (from KEGG)
    Endocrine resistance, conserved biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
  • NOTCH2 Activation and Transmission of Signal to the Nucleus, organism-specific biosystem (from REACTOME)
    NOTCH2 Activation and Transmission of Signal to the Nucleus, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Notch Signaling Pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
  • Notch signaling, organism-specific biosystem (from KEGG)
    Notch signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • Notch signaling, conserved biosystem (from KEGG)
    Notch signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Notch signaling pathway, organism-specific biosystem (from KEGG)
    Notch signaling pathway, organism-specific biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
  • Notch signaling pathway, conserved biosystem (from KEGG)
    Notch signaling pathway, conserved biosystemThe Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch pro...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by NOTCH2, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH2, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by NOTCH3, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH3, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by NOTCH4, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Th1 and Th2 cell differentiation, organism-specific biosystem (from KEGG)
    Th1 and Th2 cell differentiation, organism-specific biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...
  • Th1 and Th2 cell differentiation, conserved biosystem (from KEGG)
    Th1 and Th2 cell differentiation, conserved biosystemImmunity to different classes of microorganisms is orchestrated by separate lineages of effector T helper (TH)-cells, which differentiate from naive CD4+ precursor cells in response to cues provided ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
Notch binding IEA
Inferred from Electronic Annotation
more info
 
Notch binding ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Notch signaling involved in heart development IEA
Inferred from Electronic Annotation
more info
 
Notch signaling involved in heart development ISO
Inferred from Sequence Orthology
more info
 
Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
blood vessel lumenization IEA
Inferred from Electronic Annotation
more info
 
blood vessel lumenization ISO
Inferred from Sequence Orthology
more info
 
blood vessel remodeling IEA
Inferred from Electronic Annotation
more info
 
blood vessel remodeling ISO
Inferred from Sequence Orthology
more info
 
branching involved in blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
branching involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cardiac atrium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cardiac atrium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cardiac ventricle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cellular response to fibroblast growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
dorsal aorta morphogenesis IEA
Inferred from Electronic Annotation
more info
 
dorsal aorta morphogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood vessel endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
pericardium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
pericardium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of neural retina development IEA
Inferred from Electronic Annotation
more info
 
regulation of neural retina development ISO
Inferred from Sequence Orthology
more info
 
regulation of neurogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
ventral spinal cord interneuron fate commitment ISO
Inferred from Sequence Orthology
more info
 
ventricular trabecula myocardium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
ventricular trabecula myocardium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
delta-like protein 4
Names
delta-like 4
delta4
drosophila Delta homolog 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107760.1NP_001101230.1  delta-like protein 4 precursor

    See identical proteins and their annotated locations for NP_001101230.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473949
    Conserved Domains (3) summary
    cd00054
    Location:328360
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01414
    Location:155217
    DSL; Delta serrate ligand
    pfam07657
    Location:2788
    MNNL; N terminus of Notch ligand

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    111135011..111146746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234765.2XP_006234827.1  delta-like protein 4 isoform X1

    UniProtKB/Swiss-Prot
    D3ZHH1
    Related
    ENSRNOP00000018970.6, ENSRNOT00000018970.6
    Conserved Domains (3) summary
    cd00054
    Location:329361
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01414
    Location:156218
    DSL; Delta serrate ligand
    pfam07657
    Location:2889
    MNNL; N terminus of Notch ligand

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    105230387..105240148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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