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Dll4 delta like canonical Notch ligand 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311332, updated on 6-May-2021

Summary

Official Symbol
Dll4provided by RGD
Official Full Name
delta like canonical Notch ligand 4provided by RGD
Primary source
RGD:1309740
See related
Ensembl:ENSRNOG00000014011
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Lung (RPKM 143.2), Heart (RPKM 59.0) and 7 other tissues See more
Orthologs
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Genomic context

See Dll4 in Genome Data Viewer
Location:
3q35
Exon count:
11
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (106317114..106327004)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (111135011..111146746)

Chromosome 3 - NC_051338.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene VPS18 core subunit of CORVET and HOPS complexes Neighboring gene uncharacterized LOC103691871 Neighboring gene ChaC glutathione-specific gamma-glutamylcyclotransferase 1 Neighboring gene INO80 complex ATPase subunit

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Notch binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Notch binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Notch signaling involved in heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in blood vessel lumenization ISO
Inferred from Sequence Orthology
more info
 
involved_in blood vessel remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in branching involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac atrium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac ventricle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to fibroblast growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in dorsal aorta morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in pericardium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neural retina development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in ventral spinal cord interneuron fate commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular trabecula myocardium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
delta-like protein 4
Names
delta-like 4
delta4
drosophila Delta homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107760.1NP_001101230.1  delta-like protein 4 precursor

    See identical proteins and their annotated locations for NP_001101230.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473949
    Conserved Domains (3) summary
    cd00054
    Location:328360
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01414
    Location:155217
    DSL; Delta serrate ligand
    pfam07657
    Location:2788
    MNNL; N terminus of Notch ligand

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051338.1 Reference mRatBN7.2 Primary Assembly

    Range
    106317114..106327004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234765.3XP_006234827.1  delta-like protein 4 isoform X1

    UniProtKB/Swiss-Prot
    D3ZHH1
    Related
    ENSRNOP00000018970.6
    Conserved Domains (3) summary
    cd00054
    Location:329361
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam01414
    Location:156218
    DSL; Delta serrate ligand
    pfam07657
    Location:2889
    MNNL; N terminus of Notch ligand
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