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Ttc17 tetratricopeptide repeat domain 17 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311224, updated on 8-Apr-2026
Official Symbol
Ttc17provided by RGD
Official Full Name
tetratricopeptide repeat domain 17provided by RGD
Primary source
RGD:1305410
See related
Ensembl:ENSRNOG00000010495 AllianceGenome:RGD:1305410
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in actin filament polymerization and cilium organization. Located in cytoplasm. Orthologous to human TTC17 (tetratricopeptide repeat domain 17). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Liver (RPKM 129.9), Lung (RPKM 127.5) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Ttc17 in Genome Data Viewer
Location:
3q31
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (100718820..100829464, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (80263488..80374137, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (83198829..83306622, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene microRNA 129-2 Neighboring gene apoptosis inhibitor 5 Neighboring gene small nucleolar RNA SNORA17

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. C2orf62 and TTC17 are involved in actin organization and ciliogenesis in zebrafish and human. Bontems F, et al. PLoS One, 2014. PMID 24475127, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cilium organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium organization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
tetratricopeptide repeat protein 17
Names
TPR repeat protein 17

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107752.2 → NP_001101222.2  tetratricopeptide repeat protein 17 precursor

    See identical proteins and their annotated locations for NP_001101222.2

    Status: PROVISIONAL

    Source sequence(s)
    BC168714
    UniProtKB/Swiss-Prot
    B5DEL3, F1MA48
    UniProtKB/TrEMBL
    A0ABK0LNC3
    Related
    ENSRNOP00000014088.6, ENSRNOT00000014088.9
    Conserved Domains (6) summary
    smart00028
    Location:689 → 718
    TPR; Tetratricopeptide repeats
    sd00006
    Location:621 → 647
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:1145 → 1175
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:1111 → 1173
    TPR_11; TPR repeat
    cd16269
    Location:379 → 390
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:329 → 410
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    100718820..100829464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591720.3 → XP_017447209.1  tetratricopeptide repeat protein 17 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GIU8, A0ABK0LNC3
    Related
    ENSRNOP00000090386.1, ENSRNOT00000099588.2

  2. XM_063283679.1 → XP_063139749.1  tetratricopeptide repeat protein 17 isoform X2

    UniProtKB/TrEMBL
    A0ABK0LNC3

  3. XM_063283678.1 → XP_063139748.1  tetratricopeptide repeat protein 17 isoform X1

    UniProtKB/TrEMBL
    A0ABK0LNC3

  4. XM_006234582.5 → XP_006234644.1  tetratricopeptide repeat protein 17 isoform X4

    UniProtKB/TrEMBL
    A0ABK0LNC3
    Conserved Domains (5) summary
    smart00028
    Location:689 → 718
    TPR; Tetratricopeptide repeats
    sd00006
    Location:621 → 647
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:658 → 718
    TPR_11; TPR repeat
    cd16269
    Location:379 → 390
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:329 → 410
    GBP_C; Guanylate-binding protein, C-terminal domain

  5. XM_039104915.2 → XP_038960843.1  tetratricopeptide repeat protein 17 isoform X6

    Conserved Domains (5) summary
    COG0457
    Location:563 → 718
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:621 → 647
    TPR; TPR repeat [structural motif]
    cd16269
    Location:379 → 390
    GBP_C; coiled coil [structural motif]
    pfam00515
    Location:297 → 328
    TPR_1; Tetratricopeptide repeat
    cl20817
    Location:329 → 410
    GBP_C; Guanylate-binding protein, C-terminal domain

  6. XM_017591721.3 → XP_017447210.1  tetratricopeptide repeat protein 17 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZKB8
    Related
    ENSRNOP00000077556.1, ENSRNOT00000110475.2

RNA

  1. XR_005501867.2 RNA Sequence

  2. XR_005501866.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B5DEL3.1 GenPept UniProtKB/Swiss-Prot:B5DEL3

Gene LinkOut

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