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Rap1gds1 Rap1 GTPase-GDP dissociation stimulator 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310909, updated on 5-Sep-2025
Official Symbol
Rap1gds1provided by RGD
Official Full Name
Rap1 GTPase-GDP dissociation stimulator 1provided by RGD
Primary source
RGD:1308558
See related
Ensembl:ENSRNOG00000015987 AllianceGenome:RGD:1308558
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in myosin filament assembly; positive regulation of GTPase activity; and vascular associated smooth muscle contraction. Predicted to be located in several cellular components, including endoplasmic reticulum; extracellular space; and mitochondrion. Predicted to be active in cytosol. Orthologous to human RAP1GDS1 (Rap1 GTPase-GDP dissociation stimulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Brain (RPKM 234.3), Kidney (RPKM 77.2) and 9 other tissues See more
Orthologs
human mouse all
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See Rap1gds1 in Genome Data Viewer
Location:
2q44
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (230173713..230318555, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (227500366..227645213, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (244258550..244370983, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene CRACD-like protein Neighboring gene tetraspanin 5 Neighboring gene heat shock protein family A (Hsp70) member 8, pseudogene 20 Neighboring gene uncharacterized LOC120100955 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene NME/NM23 nucleoside diphosphate kinase 2, pseudogene 3

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. SmgGDS antagonizes BPGAP1-induced Ras/ERK activation and neuritogenesis in PC12 cell differentiation. Ravichandran A, et al. Mol Biol Cell, 2013 Jan. PMID 23155002, Free PMC Article
  2. Identification and characterization of the unique guanine nucleotide exchange factor, SmgGDS, in vascular smooth muscle cells. Thill R, et al. J Cell Biochem, 2008 Aug 1. PMID 18348285
  3. betaPak-interacting exchange factor-mediated Rac1 activation requires smgGDS guanine nucleotide exchange factor in basic fibroblast growth factor-induced neurite outgrowth. Shin EY, et al. J Biol Chem, 2006 Nov 24. PMID 16954223
  4. Transglutaminase 2 contributes to apoptosis induction in Jurkat T cells by modulating Ca2+ homeostasis via cross-linking RAP1GDS1. Hsieh YF, et al. PLoS One, 2013. PMID 24349085, Free PMC Article
  5. Anaplastic lymphoma kinase activates the small GTPase Rap1 via the Rap1-specific GEF C3G in both neuroblastoma and PC12 cells. Schönherr C, et al. Oncogene, 2010 May 13. PMID 20190816

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SmgGDS, a novel Ras regulator, suppresses Ras-BPGAP1-induced Ras/ERK activation.
    Title: SmgGDS antagonizes BPGAP1-induced Ras/ERK activation and neuritogenesis in PC12 cell differentiation.
  2. ALK activation of Rap1 via the Rap1-specific GEF C3Gmay contribute to cell proliferation and oncogenesis of neuroblastoma.
    Title: Anaplastic lymphoma kinase activates the small GTPase Rap1 via the Rap1-specific GEF C3G in both neuroblastoma and PC12 cells.
  3. These results identify SmgGDS as a novel regulator of myosin organization and contraction in vascular smooth muscle cells.
    Title: Identification and characterization of the unique guanine nucleotide exchange factor, SmgGDS, in vascular smooth muscle cells.
  4. betaPak-interacting exchange factor-mediated Rac1 activation requires smgGDS guanine nucleotide exchange factor in basic fibroblast growth factor-induced neurite outgrowth
    Title: betaPak-interacting exchange factor-mediated Rac1 activation requires smgGDS guanine nucleotide exchange factor in basic fibroblast growth factor-induced neurite outgrowth.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in CAAX-box protein maturation IEA
Inferred from Electronic Annotation
more info
  
involved_in CAAX-box protein maturation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within angiotensin-activated signaling pathway involved in heart process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within angiotensin-activated signaling pathway involved in heart process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cardiac muscle hypertrophy IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within heart process ISO
Inferred from Sequence Orthology
more info
  
involved_in myosin filament assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of endoplasmic reticulum calcium ion concentration IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of endoplasmic reticulum calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitochondrial calcium ion concentration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitochondrial calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of ERK5 cascade IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of ERK5 cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of matrix metallopeptidase secretion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of matrix metallopeptidase secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrion organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in vascular associated smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
rap1 GTPase-GDP dissociation stimulator 1
Names
RAP1, GTP-GDP dissociation stimulator 1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107728.3 → NP_001101198.2  rap1 GTPase-GDP dissociation stimulator 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6HW43, F1M7Y3
    Related
    ENSRNOP00000021457.7, ENSRNOT00000021458.9

  2. NM_001415062.2 → NP_001401991.1  rap1 GTPase-GDP dissociation stimulator 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A0G2K1D2, A6HW44
    Related
    ENSRNOP00000071795.2, ENSRNOT00000084860.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    230173713..230318555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102470.2 → XP_038958398.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X1

    UniProtKB/TrEMBL
    A6HW44
    Conserved Domains (4) summary
    smart00185
    Location:346 → 389
    ARM; Armadillo/beta-catenin-like repeats
    PLN03200
    Location:18 → 264
    PLN03200; cellulose synthase-interactive protein; Provisional
    sd00043
    Location:91 → 116
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:86 → 117
    Arm; Armadillo/beta-catenin-like repeat

  2. XM_039102469.2 → XP_038958397.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X2

    UniProtKB/TrEMBL
    A6HW44
    Conserved Domains (4) summary
    smart00185
    Location:346 → 389
    ARM; Armadillo/beta-catenin-like repeats
    PLN03200
    Location:18 → 264
    PLN03200; cellulose synthase-interactive protein; Provisional
    sd00043
    Location:91 → 116
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:86 → 117
    Arm; Armadillo/beta-catenin-like repeat

  3. XM_063281978.1 → XP_063138048.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X4

    UniProtKB/TrEMBL
    A6HW43

  4. XM_039102473.2 → XP_038958401.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X3

    UniProtKB/TrEMBL
    A6HW43
    Conserved Domains (3) summary
    smart00185
    Location:297 → 340
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:44 → 71
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:86 → 117
    Arm; Armadillo/beta-catenin-like repeat

  5. XM_039102477.2 → XP_038958405.1  rap1 GTPase-GDP dissociation stimulator 1 isoform X5

    UniProtKB/TrEMBL
    A6HW43
    Conserved Domains (2) summary
    smart00185
    Location:168 → 211
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:173 → 212
    ARM; armadillo repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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