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png pan gu [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31084, updated on 7-Aug-2025
Official Symbol
pngprovided by FlyBase
Official Full Name
pan guprovided by FlyBase
Primary source
FLYBASE:FBgn0000826
Locus tag
Dmel_CG11420
See related
AllianceGenome:FB:FBgn0000826
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11420; Dmel\CG11420; EG:8D8.5; fs(1)M2; pan-gnu; Png; PNG
Summary
Enables protein serine/threonine kinase activity. Involved in egg activation and positive regulation of mitotic cell cycle, embryonic. Part of serine/threonine protein kinase complex. Is expressed in organism and unfertilized egg. Orthologous to human NEK3 (NIMA related kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Location:
1F4-1F4; 1-0.1 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1356488..1357601, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1250521..1251634, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene sister-of-Sex-lethal Neighboring gene mir-4961 stem loop

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Widespread changes in the posttranscriptional landscape at the Drosophila oocyte-to-embryo transition. Kronja I, et al. Cell Rep, 2014 Jun 12. PMID 24882012, Free PMC Article
  2. The Drosophila plutonium and pan gu genes regulate entry into S phase at fertilization. Shamanski FL, et al. Cell, 1991 Sep 20. PMID 1913810
  3. Mechanisms restricting DNA replication to once per cell cycle: MCMS, pre-replicative complexes and kinases. Romanowski P, et al. Trends Cell Biol, 1996 May. PMID 15157470
  4. Premature translation of the Drosophila zygotic genome activator Zelda is not sufficient to precociously activate gene expression. Larson ED, et al. G3 (Bethesda), 2022 Aug 25. PMID 35876878, Free PMC Article
  5. The function of the Drosophila thioredoxin homologue encoded by the deadhead gene is redox-dependent and blocks the initiation of development but not DNA synthesis. Pellicena-Pallé A, et al. Mech Dev, 1997 Feb. PMID 9106167

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An unbiased biochemical screen for Pan Gu substrates identified the conserved translational repressor Trailer Hitch (TRAL).
    Title: Identification of PNG kinase substrates uncovers interactions with the translational repressor TRAL in the oocyte-to-embryo transition.
  2. Here the authors show that CDK1 phosphorylation of GNU negatively regulates PNG kinase activity.
    Title: Control of PNG kinase, a key regulator of mRNA translation, is coupled to meiosis completion at egg activation.
  3. These data argue that changes in poly(A) tail length are not a universal mechanism governing embryonic cell cycles, and that PNG-mediated derepression of translation is an important alternative mechanism in Drosophila.
    Title: The Drosophila PNG kinase complex regulates the translation of cyclin B.
  4. In Drosophila, the PAN GU (PNG) triggers translation of SMAUG (SMG), a multifunctional posttranscriptional regulator conserved from yeast to humans.
    Title: SMAUG is a major regulator of maternal mRNA destabilization in Drosophila and its translation is activated by the PAN GU kinase.
  5. component of novel protein kinase complex that specifically regulates S-M cell cycles
    Title: The Drosophila cell cycle kinase PAN GU forms an active complex with PLUTONIUM and GNU to regulate embryonic divisions.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in egg activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic cell cycle, embryonic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic cell cycle TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein kinase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of serine/threonine protein kinase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
pan gu
Names
CG11420-PA
png-PA
NP_477492.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    1356488..1357601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058144.3 → NP_477492.1  pan gu

    See identical proteins and their annotated locations for NP_477492.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O46308, Q8SZA4
    Related
    FBpp0070225
    Conserved Domains (2) summary
    smart00220
    Location:11 → 271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:9 → 214
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O46308 O46308
Q8SZA4 Q8SZA4

Gene LinkOut

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