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CDC45L [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31052, updated on 4-Dec-2018

Summary

Official Symbol
CDC45Lprovided by FlyBase
Primary source
FLYBASE:FBgn0026143
Locus tag
Dmel_CG3658
Gene type
protein coding
RNA name
CDC45L
RefSeq status
REVIEWED
Organism
Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-1Ec; cdc45; Cdc45; CDC45; CG3658; D; dCDC45; dCDC45L; DmCdc45; Dmel\CG3658; EG:BACR7A4.11

Genomic context

See CDC45L in Genome Data Viewer
Location:
1E1-1E1; 1-0.1 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1028291..1030556, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (922324..924589, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene suppressor of white-apricot Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the CDC45L gene: The CDC45L gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to 3'-5' DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA amplification IEP
Inferred from Expression Pattern
more info
PubMed 
DNA replication IPI
Inferred from Physical Interaction
more info
PubMed 
DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA replication initiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
chromosome condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic DNA replication preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of chromatin silencing at telomere IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
DNA replication preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pre-replicative complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pre-replicative complex IPI
Inferred from Physical Interaction
more info
PubMed 
nuclear pre-replicative complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
replication fork protection complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
CDC45L
Names
CDC45L-PA
CG3658-PA
transcription unit D

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    1028291..1030556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_130524.5NP_569880.1  CDC45L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569880.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O96989
    Related
    FBpp0070175, FBtr0070182
    Conserved Domains (1) summary
    pfam02724
    Location:19571
    CDC45; CDC45-like protein
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