Format

Send to:

Choose Destination

Plch1 phospholipase C, eta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310463, updated on 3-Oct-2018

Summary

Official Symbol
Plch1provided by RGD
Official Full Name
phospholipase C, eta 1provided by RGD
Primary source
RGD:1561991
See related
Ensembl:ENSRNOG00000009955 Vega:OTTRNOG00000001220
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Plcl3; RGD1561991
Expression
Biased expression in Lung (RPKM 34.1), Brain (RPKM 28.4) and 4 other tissues See more
Orthologs

Genomic context

See Plch1 in Genome Data Viewer
Location:
2q31
Exon count:
24
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (154256382..154468166, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (173640220..173849566, complement)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546391 Neighboring gene tetratricopeptide repeat domain 11 Neighboring gene similar to hypothetical protein E130311K13 Neighboring gene solute carrier family 33 member 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 
phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
intracellular IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
Names
phospholipase C-like 3
NP_001178636.1
XP_017446352.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191707.1NP_001178636.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1

    Status: PROVISIONAL

    Source sequence(s)
    AABR03013210, AABR03014192, AABR03014543, AABR03016635
    Related
    ENSRNOP00000068291.1, OTTRNOP00000001071, ENSRNOT00000076165.2, OTTRNOT00000001868
    Conserved Domains (6) summary
    cd00275
    Location:713837
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:280683
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd00051
    Location:128194
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:209280
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:129190
    EF-hand_7; EF-hand domain pair
    cl17171
    Location:4110
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    154256382..154468166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017590863.1XP_017446352.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    Conserved Domains (6) summary
    cd00275
    Location:744868
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310714
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd00051
    Location:158224
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:239310
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:159220
    EF-hand_7; EF-hand domain pair
    cl17171
    Location:34140
    PH-like; Pleckstrin homology-like domain

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    142435231..142522875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center