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Myo10 myosin X [ Rattus norvegicus (Norway rat) ]

Gene ID: 310178, updated on 13-Apr-2024

Summary

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Official Symbol
Myo10provided by RGD
Official Full Name
myosin Xprovided by RGD
Primary source
RGD:1307193
See related
Ensembl:ENSRNOG00000010161 AllianceGenome:RGD:1307193
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cytoskeletal protein binding activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and plus-end directed microfilament motor activity. Predicted to be involved in cytoskeleton-dependent intracellular transport; regulation of cell shape; and regulation of filopodium assembly. Predicted to act upstream of or within positive regulation of cell-cell adhesion. Predicted to be located in several cellular components, including filopodium tip; neuronal cell body; and nucleolus. Predicted to be part of myosin complex. Orthologous to human MYO10 (myosin X). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 369.3), Kidney (RPKM 227.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q22
Exon count:
47
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (77831532..78036137)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (76100989..76305619)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (77868398..78072443)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene CWC15 spliceosome-associated protein, pseudogene 3 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene uncharacterized LOC134485861 Neighboring gene uncharacterized LOC108349968 Neighboring gene reticulophagy regulator 1 Neighboring gene 60S ribosomal protein L7a pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Myosin-X is a molecular motor that functions in filopodia formation. Bohil AB, et al. Proc Natl Acad Sci U S A, 2006 Aug 15. PMID 16894163, Free PMC Article
  2. Myo10 in brain: developmental regulation, identification of a headless isoform and dynamics in neurons. Sousa AD, et al. J Cell Sci, 2006 Jan 1. PMID 16371656
  3. Myosin X is a downstream effector of PI(3)K during phagocytosis. Cox D, et al. Nat Cell Biol, 2002 Jul. PMID 12055636
  4. Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme. Uchiyama Y, et al. Proc Natl Acad Sci U S A, 2010 May 18. PMID 20439720, Free PMC Article
  5. The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route. Papal S, et al. Hum Mol Genet, 2013 Sep 15. PMID 23704327

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables plus-end directed microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables plus-end directed microfilament motor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables spectrin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton-dependent intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton-dependent intracellular transport ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of filopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of filopodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in filopodium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in filopodium ISO
Inferred from Sequence Orthology
more info
  
located_in filopodium membrane IEA
Inferred from Electronic Annotation
more info
  
located_in filopodium tip ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
unconventional myosin-X
Names
unconventional myosin-10
unconventionnal myosin-X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401822.1 → NP_001388751.1  unconventional myosin-X

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    D3ZJP6
    Related
    ENSRNOP00000063102.2, ENSRNOT00000065897.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    77831532..78036137
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102214.2 → XP_038958142.1  unconventional myosin-X isoform X2

    UniProtKB/TrEMBL
    A6JMW4, D3ZZ73, F1M9V6
    Conserved Domains (10) summary
    smart00139
    Location:908 → 1054
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:1063 → 1317
    B41; Band 4.1 homologues
    COG5022
    Location:2 → 288
    COG5022; Myosin heavy chain [General function prediction only]
    cd13202
    Location:1313 → 1401
    FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
    cd13296
    Location:574 → 675
    PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
    cd13297
    Location:740 → 865
    PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
    cd17206
    Location:1056 → 1151
    FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X
    NF033845
    Location:345 → 527
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    cl17171
    Location:540 → 582
    PH-like; Pleckstrin homology-like domain
    cl22853
    Location:1 → 84
    Motor_domain; Myosin and Kinesin motor domain

  2. XM_039102215.2 → XP_038958143.1  unconventional myosin-X isoform X2

    UniProtKB/TrEMBL
    A6JMW4, D3ZZ73, F1M9V6
    Conserved Domains (10) summary
    smart00139
    Location:908 → 1054
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:1063 → 1317
    B41; Band 4.1 homologues
    COG5022
    Location:2 → 288
    COG5022; Myosin heavy chain [General function prediction only]
    cd13202
    Location:1313 → 1401
    FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
    cd13296
    Location:574 → 675
    PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
    cd13297
    Location:740 → 865
    PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
    cd17206
    Location:1056 → 1151
    FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X
    NF033845
    Location:345 → 527
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    cl17171
    Location:540 → 582
    PH-like; Pleckstrin homology-like domain
    cl22853
    Location:1 → 84
    Motor_domain; Myosin and Kinesin motor domain

  3. XM_039102218.2 → XP_038958146.1  unconventional myosin-X isoform X2

    UniProtKB/TrEMBL
    A6JMW4, D3ZZ73, F1M9V6
    Conserved Domains (10) summary
    smart00139
    Location:908 → 1054
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:1063 → 1317
    B41; Band 4.1 homologues
    COG5022
    Location:2 → 288
    COG5022; Myosin heavy chain [General function prediction only]
    cd13202
    Location:1313 → 1401
    FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
    cd13296
    Location:574 → 675
    PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
    cd13297
    Location:740 → 865
    PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
    cd17206
    Location:1056 → 1151
    FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X
    NF033845
    Location:345 → 527
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    cl17171
    Location:540 → 582
    PH-like; Pleckstrin homology-like domain
    cl22853
    Location:1 → 84
    Motor_domain; Myosin and Kinesin motor domain

  4. XM_039102216.2 → XP_038958144.1  unconventional myosin-X isoform X2

    UniProtKB/TrEMBL
    A6JMW4, D3ZZ73, F1M9V6
    Conserved Domains (10) summary
    smart00139
    Location:908 → 1054
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:1063 → 1317
    B41; Band 4.1 homologues
    COG5022
    Location:2 → 288
    COG5022; Myosin heavy chain [General function prediction only]
    cd13202
    Location:1313 → 1401
    FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
    cd13296
    Location:574 → 675
    PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
    cd13297
    Location:740 → 865
    PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
    cd17206
    Location:1056 → 1151
    FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X
    NF033845
    Location:345 → 527
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    cl17171
    Location:540 → 582
    PH-like; Pleckstrin homology-like domain
    cl22853
    Location:1 → 84
    Motor_domain; Myosin and Kinesin motor domain

  5. XM_063281749.1 → XP_063137819.1  unconventional myosin-X isoform X2

  6. XM_039102213.2 → XP_038958141.1  unconventional myosin-X isoform X1

    UniProtKB/TrEMBL
    A6JMW4, D3ZZ73, F1M9V6
    Conserved Domains (10) summary
    smart00139
    Location:909 → 1055
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:1064 → 1318
    B41; Band 4.1 homologues
    COG5022
    Location:3 → 289
    COG5022; Myosin heavy chain [General function prediction only]
    cd13202
    Location:1314 → 1402
    FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)
    cd13296
    Location:575 → 676
    PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2
    cd13297
    Location:741 → 866
    PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3
    cd17206
    Location:1057 → 1152
    FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X
    NF033845
    Location:346 → 528
    MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    cl17171
    Location:541 → 583
    PH-like; Pleckstrin homology-like domain
    cl22853
    Location:2 → 85
    Motor_domain; Myosin and Kinesin motor domain

  7. XM_063281750.1 → XP_063137820.1  unconventional myosin-X isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107657.1: Suppressed sequence

    Description
    NM_001107657.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZJP6.1 GenPept UniProtKB/Swiss-Prot:D3ZJP6

Gene LinkOut

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