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HK3 hexokinase 3 [ Homo sapiens (human) ]

Gene ID: 3101, updated on 19-Jun-2024

Summary

Official Symbol
HK3provided by HGNC
Official Full Name
hexokinase 3provided by HGNC
Primary source
HGNC:HGNC:4925
See related
Ensembl:ENSG00000160883 MIM:142570; AllianceGenome:HGNC:4925
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HXK3; HKIII
Summary
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]
Expression
Biased expression in bone marrow (RPKM 50.3), spleen (RPKM 14.0) and 3 other tissues See more
Orthologs
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Genomic context

See HK3 in Genome Data Viewer
Location:
5q35.2
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (176880869..176899346, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (177426695..177445172, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176307870..176326347, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176087757-176088480 Neighboring gene uncharacterized LOC124901144 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:176093385-176093611 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176098601-176099166 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:176099167-176099730 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176106874-176107834 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176107835-176108794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176119741-176120285 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176124309-176125132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176126779-176127601 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176139283-176140243 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176148139-176148638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176152218-176152749 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176152750-176153280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176160291-176161220 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176159360-176160290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176167545-176168254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176170772-176171740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176174798-176175456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176176117-176176775 Neighboring gene long intergenic non-protein coding RNA 1574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176211747-176212340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176212935-176213528 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:176214607-176215806 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176219277-176220119 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176220120-176220961 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176225159-176226105 Neighboring gene MPRA-validated peak5589 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23691 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176257203-176258159 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176271727-176272558 Neighboring gene unc-5 netrin receptor A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176284513-176285014 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176295664-176296411 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:176299555-176299736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176302473-176303396 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:176306956-176307321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176314417-176314917 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:176327167-176327668 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:176370315-176371173 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:176371174-176372031 Neighboring gene ubiquitin interaction motif containing 1 Neighboring gene uncharacterized LOC124901145 Neighboring gene MPRA-validated peak5592 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16666 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16668 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:176449401-176449938 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:176449939-176450475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16670 Neighboring gene zinc finger protein 346 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:176488686-176489885

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables D-glucose binding IEA
Inferred from Electronic Annotation
more info
 
enables fructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables fructokinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables glucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glucokinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables glucokinase activity TAS
Traceable Author Statement
more info
 
enables hexokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in canonical glycolysis TAS
Traceable Author Statement
more info
 
involved_in carbohydrate phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fructose 6-phosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glucose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glucose 6-phosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
hexokinase-3
Names
ATP:D-hexose 6-phosphotransferase
HK III
hexokinase 3 (white cell)
hexokinase type III
hexokinase-C
NP_002106.2
XP_011532842.1
XP_047273090.1
XP_054208457.1
XP_054208458.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047006.1 RefSeqGene

    Range
    5028..23505
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002115.3NP_002106.2  hexokinase-3

    See identical proteins and their annotated locations for NP_002106.2

    Status: REVIEWED

    Source sequence(s)
    AC027318, BC028129, BX644742, U51333
    Consensus CDS
    CCDS4407.1
    UniProtKB/Swiss-Prot
    P52790, Q8N1E7
    UniProtKB/TrEMBL
    Q59H08
    Related
    ENSP00000292432.5, ENST00000292432.10
    Conserved Domains (3) summary
    PLN02914
    Location:72471
    PLN02914; hexokinase
    pfam00349
    Location:483673
    Hexokinase_1
    pfam03727
    Location:679913
    Hexokinase_2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    176880869..176899346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417134.1XP_047273090.1  hexokinase-3 isoform X1

  2. XM_011534540.3XP_011532842.1  hexokinase-3 isoform X2

    Conserved Domains (3) summary
    PTZ00107
    Location:39474
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:33230
    Hexokinase_1; Hexokinase
    pfam03727
    Location:238472
    Hexokinase_2; Hexokinase

RNA

  1. XR_941102.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    177426695..177445172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352482.1XP_054208457.1  hexokinase-3 isoform X1

  2. XM_054352483.1XP_054208458.1  hexokinase-3 isoform X2

RNA

  1. XR_008487114.1 RNA Sequence