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HK3 hexokinase 3 [ Homo sapiens (human) ]

Gene ID: 3101, updated on 3-May-2020

Summary

Official Symbol
HK3provided by HGNC
Official Full Name
hexokinase 3provided by HGNC
Primary source
HGNC:HGNC:4925
See related
Ensembl:ENSG00000160883 MIM:142570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HXK3; HKIII
Summary
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]
Expression
Biased expression in bone marrow (RPKM 50.3), spleen (RPKM 14.0) and 3 other tissues See more
Orthologs

Genomic context

See HK3 in Genome Data Viewer
Location:
5q35.2
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (176880869..176899373, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176307870..176326333, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs2007 Neighboring gene tetraspanin 17 Neighboring gene long intergenic non-protein coding RNA 1574 Neighboring gene unc-5 netrin receptor A Neighboring gene ubiquitin interaction motif containing 1 Neighboring gene zinc finger protein 346

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
fructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fructokinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
glucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucokinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
glucose binding IEA
Inferred from Electronic Annotation
more info
 
hexokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
mannokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
canonical glycolysis TAS
Traceable Author Statement
more info
 
carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
cellular glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fructose 6-phosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
glucose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucose 6-phosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
hexokinase-3
Names
ATP:D-hexose 6-phosphotransferase
HK III
hexokinase 3 (white cell)
hexokinase type III
hexokinase-C
NP_002106.2
XP_011532842.1
XP_016864900.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047006.1 RefSeqGene

    Range
    5028..23505
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002115.3NP_002106.2  hexokinase-3

    See identical proteins and their annotated locations for NP_002106.2

    Status: REVIEWED

    Source sequence(s)
    AC027318, BC028129, BX644742, U51333
    Consensus CDS
    CCDS4407.1
    UniProtKB/Swiss-Prot
    P52790
    UniProtKB/TrEMBL
    A0A024R7R1
    Related
    ENSP00000292432.5, ENST00000292432.10
    Conserved Domains (3) summary
    pfam00349
    Location:483673
    Hexokinase_1; Hexokinase
    pfam03727
    Location:679913
    Hexokinase_2; Hexokinase
    cl27242
    Location:72471
    Hexokinase_2; Hexokinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    176880869..176899373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009411.1XP_016864900.1  hexokinase-3 isoform X1

  2. XM_011534540.2XP_011532842.1  hexokinase-3 isoform X2

    Conserved Domains (3) summary
    PTZ00107
    Location:39474
    PTZ00107; hexokinase; Provisional
    pfam00349
    Location:33230
    Hexokinase_1; Hexokinase
    pfam03727
    Location:238472
    Hexokinase_2; Hexokinase

RNA

  1. XR_941101.1 RNA Sequence

  2. XR_941102.2 RNA Sequence

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