ANXA7 annexin A7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ANXA7provided by HGNC
Official Full Name: annexin A7provided by HGNC
Primary source: HGNC:HGNC:545
See related: Ensembl:ENSG00000138279 MIM:186360; AllianceGenome:HGNC:545
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SNX; ANX7; SYNEXIN
Summary: Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in thyroid (RPKM 52.9), kidney (RPKM 46.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q22.2

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (73375101..73414058, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (74246516..74285473, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (75134859..75173816, complement)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AnnexinA7 promotes epithelial-mesenchymal transition by interacting with Sorcin and contributes to aggressiveness in hepatocellular carcinoma.
Title: AnnexinA7 promotes epithelial-mesenchymal transition by interacting with Sorcin and contributes to aggressiveness in hepatocellular carcinoma.
ANXA7 promotes the cell cycle, proliferation and cell adhesion-mediated drug resistance of multiple myeloma cells by up-regulating CDC5L.
Title: ANXA7 promotes the cell cycle, proliferation and cell adhesion-mediated drug resistance of multiple myeloma cells by up-regulating CDC5L.
Knockdown of annexin VII enhances nasopharyngeal carcinoma cell radiosensitivity in vivo and in vitro.
Title: Knockdown of annexin VII enhances nasopharyngeal carcinoma cell radiosensitivity in vivo and in vitro.
Annexin A7 is required for ESCRT III-mediated plasma membrane repair.
Title: Annexin A7 is required for ESCRT III-mediated plasma membrane repair.
ANXA7 regulates trophoblast proliferation and apoptosis in preeclampsia.
Title: ANXA7 regulates trophoblast proliferation and apoptosis in preeclampsia.
ANXA7 was downregulated in breast cancer cells and higher expression of ANXA7 was associated with better prognosis of breast cancer patients.
Title: Annexin A7 is correlated with better clinical outcomes of patients with breast cancer.
Annexin A7 has a prognostic role in prostate cancer progression
Title: Tissue microarray analysis delineate potential prognostic role of Annexin A7 in prostate cancer progression.
Meanwhile, the key biomarkers of cell metastasis E-cadherin expression increased while MMP-9 decreased.we found that ANXA7 played its role via MAPK/ERK pathway. ANXA7 might involve in the development of hepatocellular carcinoma and act as an oncogene which might be a potential therapeutic target for treatment.
Title: AnnexinA7 down-regulation might suppress the proliferation and metastasis of human hepatocellular carcinoma cells via MAPK/ ERK pathway.
Overexpression of ANXA7 enhances eucalyptol cytotoxicity in prostate cancer cell lines
Title: High ANXA7 Potentiates Eucalyptol Toxicity in Hormone-refractory Prostate Cancer.
Up-regulation of ANXA7-GTPase tumor suppressor reverses tumorigenesis. (Review)
Title: ANXA7-GTPase as Tumor Suppressor: Mechanisms and Therapeutic Opportunities.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-12519 (e-PCR)
- UniSTS:63538

WI-11929 (e-PCR)
- UniSTS:6719

RH47719 (e-PCR)
- UniSTS:25707

ANXA7_2109 (e-PCR)
- UniSTS:280443

GDB:369091 (e-PCR)
- UniSTS:156820

GDB:369094 (e-PCR)
- UniSTS:156821

GDB:369097 (e-PCR)
- UniSTS:156822

RH17592 (e-PCR)
- UniSTS:24781

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in membrane fusion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in response to phorbol 13-acetate 12-myristate	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
colocalizes_with chromaffin granule membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular matrix	HDA more info	PubMed
located_in membrane	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: annexin A7

Names: annexin VII; annexin-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001156.5 → NP_001147.1 annexin A7 isoform 1

See identical proteins and their annotated locations for NP_001147.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) lacks an alternate in-frame exon, compared to variant 2, resulting in a shorter protein (isoform 1) that lacks an internal segment, compared to isoform 2.

Source sequence(s)

AL512656, BQ017137, HY002854, J04543

Consensus CDS

CCDS7325.1

UniProtKB/TrEMBL

B2R7L2

Related

ENSP00000362012.4, ENST00000372921.10

Conserved Domains (2) summary

pfam00191
Location:167 → 232

Annexin; Annexin

pfam14944
Location:78 → 165

TCRP1; Tongue Cancer Chemotherapy Resistant Protein 1
NM_001320879.2 → NP_001307808.1 annexin A7 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region including an alternate in-frame exon, and initiates translation at a downstream start site compared to variant 2. The encoded isoform (4) is shorter than isoform 2.

Source sequence(s)

AL512656, BQ017137, BQ689410, BX361177, HY002854

UniProtKB/TrEMBL

B2R7L2

Conserved Domains (2) summary

pfam00191
Location:127 → 192

Annexin; Annexin

pfam04959
Location:37 → 106

ARS2; Arsenite-resistance protein 2
NM_001320880.2 → NP_001307809.1 annexin A7 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 2. The encoded isoform (3) has a shorter N-terminus than isoform 2.

Source sequence(s)

AL512656, BQ017137, BQ689410, BX361177, DA131184

UniProtKB/TrEMBL

B2R657

Conserved Domains (2) summary

pfam00191
Location:149 → 214

Annexin; Annexin

pfam04959
Location:37 → 103

ARS2; Arsenite-resistance protein 2
NM_004034.4 → NP_004025.1 annexin A7 isoform 2

See identical proteins and their annotated locations for NP_004025.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).

Source sequence(s)

AK312447, AL512656, BQ017137

Consensus CDS

CCDS7326.1

UniProtKB/Swiss-Prot

P20073, Q5F2H3, Q5T0M6, Q5T0M7

UniProtKB/TrEMBL

B2R657

Related

ENSP00000362010.4, ENST00000372919.8

Conserved Domains (2) summary

pfam00191
Location:189 → 254

Annexin; Annexin

pfam04959
Location:77 → 143

ARS2; Arsenite-resistance protein 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

73375101..73414058 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017016162.3 → XP_016871651.1 annexin A7 isoform X1

UniProtKB/Swiss-Prot

P20073, Q5F2H3, Q5T0M6, Q5T0M7

UniProtKB/TrEMBL

B2R657

Related

ENSP00000631325.1, ENST00000961266.1

Conserved Domains (2) summary

pfam00191
Location:189 → 254

Annexin; Annexin

pfam04959
Location:77 → 143

ARS2; Arsenite-resistance protein 2