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Mef2a myocyte enhancer factor 2a [ Rattus norvegicus (Norway rat) ]

Gene ID: 309957, updated on 27-Nov-2020

Summary

Official Symbol
Mef2aprovided by RGD
Official Full Name
myocyte enhancer factor 2aprovided by RGD
Primary source
RGD:1359360
See related
Ensembl:ENSRNOG00000047756
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Heart (RPKM 399.7), Lung (RPKM 276.4) and 9 other tissues See more
Orthologs

Genomic context

See Mef2a in Genome Data Viewer
Location:
1q22
Exon count:
13
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (128207715..128341681, complement)
106 current Rn_Celera (GCF_000002265.2) 1 AC_000069.1 (113052879..113157227, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (129273893..129407071, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 17 Neighboring gene LysM domain containing 4 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene uncharacterized LOC103691157

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II transcription regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
SMAD binding IEA
Inferred from Electronic Annotation
more info
 
SMAD binding ISO
Inferred from Sequence Orthology
more info
 
SMAD binding ISS
Inferred from Sequence or Structural Similarity
more info
 
activating transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
activating transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
activating transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
histone acetyltransferase binding IEA
Inferred from Electronic Annotation
more info
 
histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
 
histone acetyltransferase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
 
histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
histone deacetylase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
ERK5 cascade IEA
Inferred from Electronic Annotation
more info
 
ERK5 cascade ISO
Inferred from Sequence Orthology
more info
 
ERK5 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cardiac conduction IEA
Inferred from Electronic Annotation
more info
 
cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to calcium ion IEA
Inferred from Electronic Annotation
more info
 
cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
cellular response to glucose stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heart development ISO
Inferred from Sequence Orthology
more info
 
mitochondrial genome maintenance IEA
Inferred from Electronic Annotation
more info
 
mitochondrial genome maintenance ISO
Inferred from Sequence Orthology
more info
 
mitochondrion distribution IEA
Inferred from Electronic Annotation
more info
 
mitochondrion distribution ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cardiac muscle hypertrophy IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose import IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
ventricular cardiac myofibril assembly IEA
Inferred from Electronic Annotation
more info
 
ventricular cardiac myofibril assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin IEA
Inferred from Electronic Annotation
more info
 
chromatin ISO
Inferred from Sequence Orthology
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 
transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
myocyte-specific enhancer factor 2A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014035.2NP_001014057.1  myocyte-specific enhancer factor 2A

    See identical proteins and their annotated locations for NP_001014057.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000039
    UniProtKB/Swiss-Prot
    Q2MJT0
    UniProtKB/TrEMBL
    A0A0G2JSZ4
    Related
    ENSRNOP00000064552.1, ENSRNOT00000072915.2
    Conserved Domains (3) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam11597
    Location:129238
    Med13_N; Mediator complex subunit 13 N-terminal
    pfam12347
    Location:98152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    128207715..128341681 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759541.2XP_008757763.1  myocyte-specific enhancer factor 2A isoform X2

    UniProtKB/TrEMBL
    M0R6R7
    Related
    ENSRNOP00000065122.2, ENSRNOT00000070864.3
    Conserved Domains (2) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam12347
    Location:97150
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
  2. XM_008759542.2XP_008757764.1  myocyte-specific enhancer factor 2A isoform X3

    Conserved Domains (2) summary
    pfam12347
    Location:70124
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
    cl00109
    Location:150
    MADS; MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ ...
  3. XM_017589308.1XP_017444797.1  myocyte-specific enhancer factor 2A isoform X1

    UniProtKB/Swiss-Prot
    Q2MJT0
    UniProtKB/TrEMBL
    A0A0G2JSZ4
    Related
    ENSRNOP00000068690.1, ENSRNOT00000089723.1
    Conserved Domains (3) summary
    cd00265
    Location:278
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    pfam11597
    Location:129238
    Med13_N; Mediator complex subunit 13 N-terminal
    pfam12347
    Location:98152
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    113052879..113157227 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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