Format

Send to:

Choose Destination

Lama4 laminin subunit alpha 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309816, updated on 17-Nov-2020

Summary

Official Symbol
Lama4provided by RGD
Official Full Name
laminin subunit alpha 4provided by RGD
Primary source
RGD:1560062
See related
Ensembl:ENSRNOG00000000599
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560062
Expression
Biased expression in Heart (RPKM 457.0), Lung (RPKM 292.5) and 8 other tissues See more
Orthologs

Genomic context

See Lama4 in Genome Data Viewer
Location:
20q12
Exon count:
38
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (44060715..44201966)
106 current Rn_Celera (GCF_000002265.2) 20 AC_000088.1 (43109537..43249577)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (45786892..45926468)

Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550301 Neighboring gene ret finger protein-like 4B Neighboring gene M-phase phosphoprotein 6-like Neighboring gene family with sequence similarity 229, member B Neighboring gene tubulin, epsilon 1 Neighboring gene cellular communication network factor 6

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
blood vessel development ISO
Inferred from Sequence Orthology
more info
 
brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basement membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
synaptic cleft ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
laminin subunit alpha-4
Names
laminin, alpha 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309447.1NP_001296376.1  laminin subunit alpha-4 precursor

    See identical proteins and their annotated locations for NP_001296376.1

    Status: VALIDATED

    Source sequence(s)
    AABR07045342, AABR07045344, AABR07045345
    Related
    ENSRNOP00000000737.7, ENSRNOT00000000737.7
    Conserved Domains (7) summary
    smart00282
    Location:8531008
    LamG; Laminin G domain
    cd00055
    Location:187238
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:14831618
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam06008
    Location:289547
    Laminin_I; Laminin Domain I
    pfam06009
    Location:727854
    Laminin_II; Laminin Domain II
    cl02488
    Location:314523
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl21509
    Location:610798
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

    Range
    44060715..44201966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000088.1 Alternate Rn_Celera

    Range
    43109537..43249577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107635.1: Suppressed sequence

    Description
    NM_001107635.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Support Center