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Slc26a8 solute carrier family 26 member 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309646, updated on 11-Apr-2024

Summary

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Official Symbol
Slc26a8provided by RGD
Official Full Name
solute carrier family 26 member 8provided by RGD
Primary source
RGD:1308898
See related
Ensembl:ENSRNOG00000000512 AllianceGenome:RGD:1308898
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable anion transmembrane transporter activity. Predicted to be involved in chloride transport; oxalate transport; and sulfate transport. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in spermatogenic failure 3. Orthologous to human SLC26A8 (solute carrier family 26 member 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 102.4), Liver (RPKM 30.1) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
20p12
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (6687207..6751184, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (6686206..6749478, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5870714..5933151, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene LHFPL tetraspan subfamily member 5 Neighboring gene SRSF protein kinase 1 Neighboring gene uncharacterized LOC120098971 Neighboring gene mitogen activated protein kinase 14 Neighboring gene uncharacterized LOC134483779

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Late banding operation in children with ventricular septal defect and pulmonary arterial hypertension. Mocellin R, et al. Eur J Cardiol, 1975 Oct. PMID 1183472
  2. Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling. Toure A, et al. J Biol Chem, 2001 Jun 8. PMID 11278976
  3. Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9. Lohi H, et al. J Biol Chem, 2002 Apr 19. PMID 11834742
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables bicarbonate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride channel activity ISO
Inferred from Sequence Orthology
more info
  
enables chloride transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxalate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxalate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfate:chloride antiporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in bicarbonate transport IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in chloride transport ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in oxalate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfate transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in sperm annulus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
testis anion transporter 1
Names
solute carrier family 26 (anion exchanger), member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107614.4 → NP_001101084.2  testis anion transporter 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000020
    UniProtKB/TrEMBL
    A0A0U1RS37, F7F9X9
    Related
    ENSRNOP00000075921.1, ENSRNOT00000092383.2
    Conserved Domains (2) summary
    cd07042
    Location:697 → 772
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:76 → 582
    sulP; high affinity sulphate transporter 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    6687207..6751184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279130.1 → XP_063135200.1  testis anion transporter 1 isoform X1

  2. XM_063279137.1 → XP_063135207.1  testis anion transporter 1 isoform X11

  3. XM_063279134.1 → XP_063135204.1  testis anion transporter 1 isoform X5

  4. XM_063279139.1 → XP_063135209.1  testis anion transporter 1 isoform X15

  5. XM_063279135.1 → XP_063135205.1  testis anion transporter 1 isoform X8

  6. XM_063279136.1 → XP_063135206.1  testis anion transporter 1 isoform X10

  7. XM_063279133.1 → XP_063135203.1  testis anion transporter 1 isoform X4

  8. XM_063279132.1 → XP_063135202.1  testis anion transporter 1 isoform X3

  9. XM_063279129.1 → XP_063135199.1  testis anion transporter 1 isoform X1

  10. XM_063279142.1 → XP_063135212.1  testis anion transporter 1 isoform X20

  11. XM_063279138.1 → XP_063135208.1  testis anion transporter 1 isoform X14

  12. XM_039098696.2 → XP_038954624.1  testis anion transporter 1 isoform X7

    UniProtKB/TrEMBL
    F7F9X9
    Related
    ENSRNOP00000056031.4
    Conserved Domains (2) summary
    cd07042
    Location:691 → 766
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    pfam00916
    Location:90 → 485
    Sulfate_transp; Sulfate permease family

  13. XM_039098699.2 → XP_038954627.1  testis anion transporter 1 isoform X16

    UniProtKB/TrEMBL
    F7F9X9
    Conserved Domains (2) summary
    cd07042
    Location:645 → 720
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    pfam00916
    Location:90 → 320
    Sulfate_transp; Sulfate permease family

  14. XM_039098697.2 → XP_038954625.1  testis anion transporter 1 isoform X9

    UniProtKB/TrEMBL
    F7F9X9
    Conserved Domains (2) summary
    cd07042
    Location:677 → 752
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    pfam00916
    Location:90 → 471
    Sulfate_transp; Sulfate permease family

  15. XM_008772780.4 → XP_008771002.1  testis anion transporter 1 isoform X12

    See identical proteins and their annotated locations for XP_008771002.1

    UniProtKB/TrEMBL
    F7F9X9
    Conserved Domains (2) summary
    cd07042
    Location:665 → 740
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    pfam00916
    Location:90 → 455
    Sulfate_transp; Sulfate permease family

  16. XM_039098695.2 → XP_038954623.1  testis anion transporter 1 isoform X6

    UniProtKB/TrEMBL
    F7F9X9
    Conserved Domains (2) summary
    cd07042
    Location:698 → 773
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    pfam00916
    Location:90 → 488
    Sulfate_transp; Sulfate permease family

  17. XM_063279131.1 → XP_063135201.1  testis anion transporter 1 isoform X2

  18. XM_063279140.1 → XP_063135210.1  testis anion transporter 1 isoform X17

  19. XM_039098698.2 → XP_038954626.1  testis anion transporter 1 isoform X13

    UniProtKB/TrEMBL
    F7F9X9
    Conserved Domains (2) summary
    cd07042
    Location:660 → 735
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    pfam00916
    Location:20 → 454
    Sulfate_transp; Sulfate permease family

  20. XM_063279141.1 → XP_063135211.1  testis anion transporter 1 isoform X19

  21. XM_039098700.2 → XP_038954628.1  testis anion transporter 1 isoform X18

    UniProtKB/TrEMBL
    F7F9X9
    Conserved Domains (2) summary
    cd07042
    Location:587 → 662
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    pfam00916
    Location:50 → 381
    Sulfate_transp; Sulfate permease family

  22. XM_063279145.1 → XP_063135215.1  testis anion transporter 1 isoform X22

  23. XM_063279143.1 → XP_063135213.1  testis anion transporter 1 isoform X21

  24. XM_063279144.1 → XP_063135214.1  testis anion transporter 1 isoform X22

RNA

  1. XR_010060687.1 RNA Sequence

  2. XR_010060692.1 RNA Sequence

  3. XR_010060690.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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