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Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 [ Mus musculus (house mouse) ]

Gene ID: 30957, updated on 12-May-2024

Summary

Official Symbol
Mapk8ip3provided by MGI
Official Full Name
mitogen-activated protein kinase 8 interacting protein 3provided by MGI
Primary source
MGI:MGI:1353598
See related
Ensembl:ENSMUSG00000024163 AllianceGenome:MGI:1353598
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Jip3; Syd2; JIP-3; JSAP1; JSAP1a; JSAP1b; JSAP1c; JSAP1d; D17Wsu15e; mKIAA1066
Summary
Enables MAP-kinase scaffold activity; kinesin binding activity; and protein kinase binding activity. Involved in several processes, including anterograde axonal protein transport; positive regulation of neuron migration; and regulation of MAPK cascade. Acts upstream of or within several processes, including JNK cascade; lung development; and nervous system development. Located in several cellular components, including Golgi membrane; axolemma; and smooth endoplasmic reticulum. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; lung; and spinal cord. Orthologous to human MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 61.4), cortex adult (RPKM 55.3) and 28 other tissues See more
Orthologs
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Genomic context

See Mapk8ip3 in Genome Data Viewer
Location:
17 A3.3; 17 12.53 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25116480..25155951, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24897506..24936977, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S34 Neighboring gene essential meiotic structure-specific endonuclease subunit 2 Neighboring gene NME/NM23 nucleoside diphosphate kinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E7499 Neighboring gene Jupiter microtubule associated homolog 2 Neighboring gene STARR-positive B cell enhancer ABC_E1500 Neighboring gene cramped chromatin regulator 1 Neighboring gene STARR-positive B cell enhancer ABC_E396

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: Eme2

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables JUN kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables JUN kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables MAP-kinase scaffold activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP-kinase scaffold activity IDA
Inferred from Direct Assay
more info
PubMed 
enables MAP-kinase scaffold activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinesin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables kinesin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables kinesin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables mitogen-activated protein kinase kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables mitogen-activated protein kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables mitogen-activated protein kinase kinase kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor complex adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in anterograde axonal protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in anterograde axonal protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in axon development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon regeneration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in vesicle-mediated transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in axolemma IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in smooth endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
C-Jun-amino-terminal kinase-interacting protein 3
Names
JNK MAP kinase scaffold protein 3
JNK-interacting protein 3
JNK/SAPK-associated protein 1
JNK/SAPK-associated protein 1c
JUN/SAPK-associated protein 1
c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1
sunday driver 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163447.1NP_001156919.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform b

    See identical proteins and their annotated locations for NP_001156919.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a.
    Source sequence(s)
    AC166102
    Consensus CDS
    CCDS50024.1
    UniProtKB/TrEMBL
    Q6NV54
    Related
    ENSMUSP00000114084.2, ENSMUST00000120035.8
    Conserved Domains (3) summary
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:416484
    JIP_LZII; JNK-interacting protein leucine zipper II
  2. NM_001163448.1NP_001156920.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform c

    See identical proteins and their annotated locations for NP_001156920.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform c) compared to isoform a.
    Source sequence(s)
    AC166102, AF178636, BM899006, CO433928
    Consensus CDS
    CCDS50025.1
    UniProtKB/TrEMBL
    Q6NV54
    Related
    ENSMUSP00000110883.3, ENSMUST00000115228.9
    Conserved Domains (3) summary
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:411479
    JIP_LZII; JNK-interacting protein leucine zipper II
  3. NM_001163449.1NP_001156921.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform d

    See identical proteins and their annotated locations for NP_001156921.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate in-frame exon and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform d) compared to isoform a.
    Source sequence(s)
    AC166102, BC060603
    Consensus CDS
    CCDS50029.1
    UniProtKB/TrEMBL
    Q6P1F1
    Related
    ENSMUSP00000112712.2, ENSMUST00000117509.8
    Conserved Domains (3) summary
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:394462
    JIP_LZII; JNK-interacting protein leucine zipper II
  4. NM_001163450.1NP_001156922.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform e) compared to isoform a.
    Source sequence(s)
    AC166102
    Consensus CDS
    CCDS50028.1
    UniProtKB/TrEMBL
    E9Q6E0, Q6P1F1
    Related
    ENSMUSP00000113698.2, ENSMUST00000121723.8
    Conserved Domains (3) summary
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:386454
    JIP_LZII; JNK-interacting protein leucine zipper II
  5. NM_001163451.1NP_001156923.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform f

    See identical proteins and their annotated locations for NP_001156923.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses two alternate in-frame splice sites in the 5' coding region compared to variant 1. This results in a shorter protein (isoform f) compared to isoform a.
    Source sequence(s)
    AC166102
    Consensus CDS
    CCDS50026.1
    UniProtKB/TrEMBL
    Q6P1F1
    Related
    ENSMUSP00000112955.2, ENSMUST00000119115.8
    Conserved Domains (3) summary
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:385453
    JIP_LZII; JNK-interacting protein leucine zipper II
  6. NM_001163453.1NP_001156925.1  C-Jun-amino-terminal kinase-interacting protein 3 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the 5' coding region compared to variant 1. This results in a shorter protein (isoform g) compared to isoform a.
    Source sequence(s)
    AC166102, BC065105
    Consensus CDS
    CCDS50027.1
    UniProtKB/TrEMBL
    E9Q6B6, Q6P1F1
    Related
    ENSMUSP00000113753.2, ENSMUST00000121787.8
    Conserved Domains (3) summary
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:380448
    JIP_LZII; JNK-interacting protein leucine zipper II
  7. NM_013931.4NP_038959.2  C-Jun-amino-terminal kinase-interacting protein 3 isoform a

    See identical proteins and their annotated locations for NP_038959.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC166102, AF262046, AK134797, BM899006
    Consensus CDS
    CCDS37498.1
    UniProtKB/Swiss-Prot
    Q5D062, Q99KU7, Q9EQD8, Q9ESN7, Q9ESN8, Q9ESN9, Q9ESP0, Q9JLH2, Q9JLH3, Q9R0U7
    UniProtKB/TrEMBL
    Q3UHB5, Q6NV54
    Related
    ENSMUSP00000085683.6, ENSMUST00000088345.12
    Conserved Domains (3) summary
    pfam07926
    Location:61167
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam09744
    Location:30183
    Jnk-SapK_ap_N; JNK_SAPK-associated protein-1
    pfam16471
    Location:417485
    JIP_LZII; JNK-interacting protein leucine zipper II

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    25116480..25155951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)