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Schip1 schwannomin interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 30953, updated on 26-Sep-2022

Summary

Official Symbol
Schip1provided by MGI
Official Full Name
schwannomin interacting protein 1provided by MGI
Primary source
MGI:MGI:1353557
See related
Ensembl:ENSMUSG00000027777 AllianceGenome:MGI:1353557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nf2ip; Schip-1
Summary
Predicted to enable protein homodimerization activity. Acts upstream of or within several processes, including animal organ development; face morphogenesis; and fibroblast migration. Predicted to be located in cytoplasm. Predicted to be active in cell junction and plasma membrane. Is expressed in alimentary system; aorta; genitourinary system; nervous system; and sensory organ. Orthologous to human SCHIP1 (schwannomin interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 31.5), cerebellum adult (RPKM 31.4) and 16 other tissues See more
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Genomic context

See Schip1 in Genome Data Viewer
Location:
3; 3 E1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (67972135..68533815)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (68064802..68626482)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40068 Neighboring gene Iqcj and Schip1 fusion protein Neighboring gene IQ motif containing J Neighboring gene predicted pseudogene 5848 Neighboring gene predicted gene, 54202 Neighboring gene alkylglycerone phosphate synthase pseudogene Neighboring gene uncharacterized LOC118568618 Neighboring gene predicted gene, 22073 Neighboring gene interleukin 12a Neighboring gene predicted gene, 35584

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough Iqschfp

Readthrough gene: Iqschfp, Included gene: Iqcj

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
schwannomin-interacting protein 1
Names
neurofibromatosis 2 interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113420.1NP_001106891.1  schwannomin-interacting protein 1 isoform b

    See identical proteins and their annotated locations for NP_001106891.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 3, resulting in an isoform (b, also known as Schip-1b) that is shorter than isoform c.
    Source sequence(s)
    AC093360, BC060529, BY616163
    Consensus CDS
    CCDS50927.1
    UniProtKB/Swiss-Prot
    P0DPB4
    UniProtKB/TrEMBL
    A0A8C6I1Z8
    Related
    ENSMUSP00000129152.3, ENSMUST00000169909.10
    Conserved Domains (1) summary
    pfam10148
    Location:24250
    SCHIP-1; Schwannomin-interacting protein 1
  2. NM_001113421.1NP_001106892.1  schwannomin-interacting protein 1 isoform c

    See identical proteins and their annotated locations for NP_001106892.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c, also known as Schip-1a).
    Source sequence(s)
    AC093360, AK083464, BC060529, BY616163
    Consensus CDS
    CCDS50926.1
    UniProtKB/Swiss-Prot
    P0DPB4
    Related
    ENSMUSP00000029346.6, ENSMUST00000029346.13
    Conserved Domains (1) summary
    pfam10148
    Location:252478
    SCHIP-1; Schwannomin-interacting protein 1
  3. NM_001282044.1NP_001268973.1  schwannomin-interacting protein 1 isoform e

    See identical proteins and their annotated locations for NP_001268973.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 3. These differences cause translation initiation at a downstream AUG and result in an isoform (e) with a shorter N-terminus, compared to isoform c. Both variants 5 and 6 encode the same isoform (e).
    Source sequence(s)
    AK146930, AW492234, BY281727, BY299001, BY623736
    Consensus CDS
    CCDS71249.1
    UniProtKB/Swiss-Prot
    P0DPB4
    Related
    ENSMUSP00000138207.2, ENSMUST00000182719.8
    Conserved Domains (1) summary
    pfam10148
    Location:224450
    SCHIP-1; Schwannomin-interacting protein 1
  4. NM_001282045.1NP_001268974.1  schwannomin-interacting protein 1 isoform e

    See identical proteins and their annotated locations for NP_001268974.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 3. These differences cause translation initiation at a downstream AUG and result in an isoform (e) with a shorter N-terminus, compared to isoform c. Both variants 5 and 6 encode the same isoform (e).
    Source sequence(s)
    AK083464, BB440451, BY616163, CA750719
    Consensus CDS
    CCDS71249.1
    UniProtKB/Swiss-Prot
    P0DPB4
    Related
    ENSMUSP00000138245.2, ENSMUST00000182532.8
    Conserved Domains (1) summary
    pfam10148
    Location:224450
    SCHIP-1; Schwannomin-interacting protein 1
  5. NM_013928.5NP_038956.2  schwannomin-interacting protein 1 isoform d

    See identical proteins and their annotated locations for NP_038956.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 3. The encoded isoform (d) has a distinct and shorter N-terminus, compared to isoform c.
    Source sequence(s)
    BC060529, BY243167, BY616163
    Consensus CDS
    CCDS50929.1
    UniProtKB/Swiss-Prot
    P0DPB4
    UniProtKB/TrEMBL
    A0A097PIJ2, A0A6P5PIA9, A0A8C6I1F7
    Related
    ENSMUSP00000126443.2, ENSMUST00000170788.9
    Conserved Domains (1) summary
    pfam10148
    Location:12235
    SCHIP-1; Schwannomin-interacting protein 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    67972135..68533815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)