U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hectd2 HECT domain E3 ubiquitin protein ligase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309514, updated on 5-Jul-2025
Official Symbol
Hectd2provided by RGD
Official Full Name
HECT domain E3 ubiquitin protein ligase 2provided by RGD
Primary source
RGD:1305536
See related
Ensembl:ENSRNOG00000056753 AllianceGenome:RGD:1305536
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination. Orthologous to human HECTD2 (HECT domain E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Brain (RPKM 90.1), Heart (RPKM 83.2) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See Hectd2 in Genome Data Viewer
Location:
1q53
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (243687248..243756069)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (234274967..234345598)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (255186729..255254307)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene polycomb group ring finger 5 Neighboring gene uncharacterized LOC103691349 Neighboring gene uncharacterized LOC134485231 Neighboring gene uncharacterized LOC120100025 Neighboring gene protein phosphatase 1, regulatory subunit 3C

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
probable E3 ubiquitin-protein ligase HECTD2
Names
HECT domain containing 2
HECT domain containing E3 ubiquitin protein ligase 2
NP_001101078.3
XP_038936564.1
XP_038936565.1
XP_038936567.1
XP_063121284.1
XP_063121294.1
XP_063121298.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107608.3 → NP_001101078.3  probable E3 ubiquitin-protein ligase HECTD2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6I154
    Related
    ENSRNOP00000070631.3, ENSRNOT00000086991.3
    Conserved Domains (1) summary
    cd00078
    Location:415 → 772
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    243687248..243756069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080637.2 → XP_038936565.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X2

    UniProtKB/TrEMBL
    A6I154
    Conserved Domains (1) summary
    cd00078
    Location:454 → 811
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  2. XM_063265214.1 → XP_063121284.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X3

    UniProtKB/TrEMBL
    A6I154

  3. XM_063265228.1 → XP_063121298.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X6

  4. XM_039080639.2 → XP_038936567.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X4

    Conserved Domains (1) summary
    cl27008
    Location:416 → 506
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  5. XM_039080636.2 → XP_038936564.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JYF3, A6I154
    Conserved Domains (1) summary
    cd00078
    Location:416 → 773
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  6. XM_063265224.1 → XP_063121294.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X5

RNA

  1. XR_010053954.1 RNA Sequence

  2. XR_010053955.1 RNA Sequence

  3. XR_005487723.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous