U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cbx8 chromobox 8 [ Mus musculus (house mouse) ]

Gene ID: 30951, updated on 5-Mar-2024

Summary

Official Symbol
Cbx8provided by MGI
Official Full Name
chromobox 8provided by MGI
Primary source
MGI:MGI:1353589
See related
Ensembl:ENSMUSG00000025578 AllianceGenome:MGI:1353589
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pc3
Summary
Enables single-stranded RNA binding activity and ubiquitin-protein transferase activator activity. Acts upstream of or within histone ubiquitination and regulation of catalytic activity. Located in heterochromatin and nucleus. Part of PcG protein complex and ubiquitin ligase complex. Is expressed in several structures, including brain. Orthologous to human CBX8 (chromobox 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 2.1), CNS E11.5 (RPKM 1.9) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cbx8 in Genome Data Viewer
Location:
11 83.33 cM; 11 E2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (118929262..118931739, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (119036303..119040913, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 7 Neighboring gene predicted gene, 35829 Neighboring gene chromobox 2 Neighboring gene STARR-positive B cell enhancer ABC_E92 Neighboring gene predicted gene, 53657 Neighboring gene STARR-seq mESC enhancer starr_31312 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:118945094-118945295 Neighboring gene STARR-positive B cell enhancer ABC_E5312 Neighboring gene chromobox 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-protein transferase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of PRC1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of PRC1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
part_of heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
chromobox protein homolog 8
Names
chromobox homolog 8
mPc3
polycomb 3 homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013926.1NP_038954.1  chromobox protein homolog 8

    See identical proteins and their annotated locations for NP_038954.1

    Status: PROVISIONAL

    Source sequence(s)
    AF180370
    Consensus CDS
    CCDS25709.1
    UniProtKB/Swiss-Prot
    Q9QXV1
    Related
    ENSMUSP00000026663.8, ENSMUST00000026663.8
    Conserved Domains (1) summary
    smart00298
    Location:1062
    CHROMO; Chromatin organization modifier domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    118929262..118931739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)