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Gsto2 glutathione S-transferase omega 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309465, updated on 13-Apr-2024

Summary

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Symbol
Gsto2provided by RGD
Full Name
glutathione S-transferase omega 2provided by RGD
Primary source
RGD:1310764
See related
Ensembl:ENSRNOG00000069697 AllianceGenome:RGD:1310764
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
GSTO 2-2
Summary
Predicted to enable glutathione dehydrogenase (ascorbate) activity; glutathione transferase activity; and identical protein binding activity. Predicted to be involved in several processes, including L-ascorbic acid metabolic process; cellular response to arsenic-containing substance; and glutathione metabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and asthma. Orthologous to human GSTO2 (glutathione S-transferase omega 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 240.7), Adrenal (RPKM 50.1) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1q54
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (256673376..256695154)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (246731314..246757592)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (267617517..267640455)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein eS12-like Neighboring gene glutathione S-transferase omega 1 Neighboring gene inositol 1,4,5-trisphosphate receptor interacting protein Neighboring gene uncharacterized LOC120100050 Neighboring gene microRNA 3584 Neighboring gene cilia and flagella associated protein 58 Neighboring gene ribosomal protein L21 like 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimer's and Parkinson's diseases. Schmuck EM, et al. Pharmacogenet Genomics, 2005 Jul. PMID 15970797
  2. Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. Li YJ, et al. Hum Mol Genet, 2003 Dec 15. PMID 14570706
  3. GSTA1, GSTO1 and GSTO2 gene polymorphisms in Italian asthma patients. Polimanti R, et al. Clin Exp Pharmacol Physiol, 2010 Aug. PMID 20374258
  4. Three SNPs in the GSTO1, GSTO2 and PRSS11 genes on chromosome 10 are not associated with age-at-onset of Alzheimer's disease. Ozturk A, et al. Neurobiol Aging, 2005 Aug-Sep. PMID 15917099
  5. Glutathione S-transferase mu, omega, pi, and theta class variants and smoking in Parkinson's disease. Wahner AD, et al. Neurosci Lett, 2007 Feb 21. PMID 17194543, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glutathione dehydrogenase (ascorbate) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione dehydrogenase (ascorbate) activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione dehydrogenase (ascorbate) activity ISO
Inferred from Sequence Orthology
more info
  
enables glutathione dehydrogenase (ascorbate) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables methylarsonate reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in L-ascorbic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-ascorbic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-ascorbic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in L-ascorbic acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to arsenic-containing substance IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to arsenic-containing substance ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to arsenic-containing substance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutathione S-transferase omega-2
Names
GSTO-2
MMA(V) reductase
glutathione S-transferase omega 2-2
glutathione-dependent dehydroascorbate reductase
monomethylarsonic acid reductase
NP_001012071.1
NP_001406671.1
XP_006231652.1
XP_006231654.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012071.1 → NP_001012071.1  glutathione S-transferase omega-2

    See identical proteins and their annotated locations for NP_001012071.1

    Status: VALIDATED

    Source sequence(s)
    BC079295
    UniProtKB/Swiss-Prot
    Q6AXV9
    UniProtKB/TrEMBL
    A0A8L2Q9F9, B6DYQ6
    Related
    ENSRNOP00000017186.4, ENSRNOT00000017186.7
    Conserved Domains (2) summary
    cd03184
    Location:108 → 230
    GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
    cd03055
    Location:7 → 94
    GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

  2. NM_001419742.1 → NP_001406671.1  glutathione S-transferase omega-2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q6AXV9
    UniProtKB/TrEMBL
    B6DYQ6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    256673376..256695154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231592.3 → XP_006231654.1  glutathione S-transferase omega-2 isoform X1

    See identical proteins and their annotated locations for XP_006231654.1

    UniProtKB/Swiss-Prot
    Q6AXV9
    UniProtKB/TrEMBL
    A0A8L2Q9F9, B6DYQ6
    Conserved Domains (2) summary
    cd03184
    Location:108 → 230
    GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
    cd03055
    Location:7 → 94
    GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

  2. XM_006231590.4 → XP_006231652.1  glutathione S-transferase omega-2 isoform X1

    See identical proteins and their annotated locations for XP_006231652.1

    UniProtKB/Swiss-Prot
    Q6AXV9
    UniProtKB/TrEMBL
    A0A8L2Q9F9, B6DYQ6
    Conserved Domains (2) summary
    cd03184
    Location:108 → 230
    GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
    cd03055
    Location:7 → 94
    GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AXV9.1 GenPept UniProtKB/Swiss-Prot:Q6AXV9

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