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Gbf1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309451, updated on 18-Apr-2019

Summary

Official Symbol
Gbf1provided by RGD
Official Full Name
golgi brefeldin A resistant guanine nucleotide exchange factor 1provided by RGD
Primary source
RGD:1307160
See related
Ensembl:ENSRNOG00000026048
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1307160
Expression
Biased expression in Kidney (RPKM 169.8), Heart (RPKM 139.1) and 9 other tissues See more
Orthologs

Genomic context

See Gbf1 in Genome Data Viewer
Location:
1q54
Exon count:
41
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (265904616..266033107)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (273334980..273464048)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene ELOVL fatty acid elongase 3 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G-like Neighboring gene paired-like homeodomain 3 Neighboring gene uncharacterized LOC102551485 Neighboring gene nuclear factor kappa B subunit 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ARF guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
phosphatidylinositol-3,4,5-trisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
PubMed 
phosphatidylinositol-3,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-3,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
COPI coating of Golgi vesicle IEA
Inferred from Electronic Annotation
more info
 
COPI coating of Golgi vesicle ISO
Inferred from Sequence Orthology
more info
PubMed 
Golgi disassembly IEA
Inferred from Electronic Annotation
more info
 
Golgi disassembly ISO
Inferred from Sequence Orthology
more info
PubMed 
Golgi organization ISO
Inferred from Sequence Orthology
more info
PubMed 
Golgi to endosome transport IEA
Inferred from Electronic Annotation
more info
 
Golgi to endosome transport ISO
Inferred from Sequence Orthology
more info
PubMed 
biological_process ND
No biological Data available
more info
 
cell activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 
cell activation involved in immune response ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to virus IEA
Inferred from Electronic Annotation
more info
 
cellular response to virus ISO
Inferred from Sequence Orthology
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment organization IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum-Golgi intermediate compartment organization ISO
Inferred from Sequence Orthology
more info
PubMed 
establishment of monopolar cell polarity IEA
Inferred from Electronic Annotation
more info
 
establishment of monopolar cell polarity ISO
Inferred from Sequence Orthology
more info
PubMed 
neutrophil chemotaxis IEA
Inferred from Electronic Annotation
more info
 
neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
PubMed 
protein localization to Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
protein localization to Golgi apparatus ISO
Inferred from Sequence Orthology
more info
PubMed 
protein localization to endoplasmic reticulum exit site IEA
Inferred from Electronic Annotation
more info
 
protein localization to endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
PubMed 
protein localization to endoplasmic reticulum tubular network IEA
Inferred from Electronic Annotation
more info
 
protein localization to endoplasmic reticulum tubular network ISO
Inferred from Sequence Orthology
more info
PubMed 
reactive oxygen species biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
reactive oxygen species biosynthetic process ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of protein localization to cell surface IEA
Inferred from Electronic Annotation
more info
 
regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
PubMed 
retrograde transport, endosome to Golgi IEA
Inferred from Electronic Annotation
more info
 
retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
PubMed 
retrograde vesicle-mediated transport, Golgi to ER IEA
Inferred from Electronic Annotation
more info
 
retrograde vesicle-mediated transport, Golgi to ER ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
Golgi stack IDA
Inferred from Direct Assay
more info
PubMed 
cell leading edge IEA
Inferred from Electronic Annotation
more info
 
cell leading edge ISO
Inferred from Sequence Orthology
more info
PubMed 
cis-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
cis-Golgi network ISO
Inferred from Sequence Orthology
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
Names
golgi-specific brefeldin A resistant guanine nucleotide exchange factor 1
golgi-specific brefeldin A-resistance factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191634.1NP_001178563.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

    Status: PROVISIONAL

    Source sequence(s)
    AC096600, AC119478
    UniProtKB/TrEMBL
    F1M8X9
    Related
    ENSRNOP00000038037.5, ENSRNOT00000036156.5
    Conserved Domains (3) summary
    COG5307
    Location:4831162
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:699884
    Sec7; Sec7 domain
    pfam12783
    Location:400545
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    265904616..266033107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231496.3XP_006231558.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1

    Conserved Domains (2) summary
    pfam01369
    Location:733918
    Sec7; Sec7 domain
    pfam12783
    Location:434579
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
  2. XM_006231498.3XP_006231560.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X3

    Conserved Domains (2) summary
    pfam01369
    Location:733918
    Sec7; Sec7 domain
    pfam12783
    Location:434579
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
  3. XM_006231497.3XP_006231559.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X2

    Conserved Domains (2) summary
    pfam01369
    Location:732917
    Sec7; Sec7 domain
    pfam12783
    Location:433578
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
  4. XM_006231502.3XP_006231564.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X6

    Related
    ENSRNOP00000072707.1, ENSRNOT00000086041.1
    Conserved Domains (3) summary
    COG5307
    Location:4831162
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:699884
    Sec7; Sec7 domain
    pfam12783
    Location:400545
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
  5. XM_006231500.3XP_006231562.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X4

    Conserved Domains (3) summary
    COG5307
    Location:4841163
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:700885
    Sec7; Sec7 domain
    pfam12783
    Location:401546
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
  6. XM_006231501.3XP_006231563.1  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X5

    Conserved Domains (3) summary
    COG5307
    Location:4841163
    COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    pfam01369
    Location:700885
    Sec7; Sec7 domain
    pfam12783
    Location:401546
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    240801947..240930218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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