Hif1an hypoxia inducible factor 1 subunit alpha inhibitor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hif1anprovided by RGD
Official Full Name: hypoxia inducible factor 1 subunit alpha inhibitorprovided by RGD
Primary source: RGD:1308281
See related: Ensembl:ENSRNOG00000014234 AllianceGenome:RGD:1308281
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including 2-oxoglutarate-dependent dioxygenase activity; NF-kappaB binding activity; and transition metal ion binding activity. Predicted to be involved in negative regulation of Notch signaling pathway; positive regulation of myoblast differentiation; and regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to be located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human HIF1AN (hypoxia inducible factor 1 subunit alpha inhibitor). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Muscle (RPKM 148.3), Heart (RPKM 98.2) and 9 other tissues See more
Orthologs: all
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Genomic context

Location:: 1q54

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (253368400..253385495)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (243419175..243440464)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (264309214..264319269)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of HIF1AN remarkably decreased in the ischemia postconditioning group. This indicated that the downregulation of HIF1AN could protect cardiac cells.
Title: Cardioprotective effect of miR-214 in myocardial ischemic postconditioning by down-regulation of hypoxia inducible factor 1, alpha subunit inhibitor.
miR-31/FIH1 pathway associates with liver fibrosis, perhaps by participation in the TGF-beta/Smad3 signalling of hepatic stellate cells.
Title: The role of the miR-31/FIH1 pathway in TGF-β-induced liver fibrosis.
FIH-1 activity does not represent a major mechanism by which NP cells control HIF-1-dependent transcription, a testament to their adaptation to a unique hypoxic niche.
Title: FIH-1-Mint3 axis does not control HIF-1 transcriptional activity in nucleus pulposus cells.
FIH1 appears to be a suppressor of oxygen-dependent genes in the kidney, operating through HIF-dependent and -independent mechanisms.
Title: Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells.

Submit: New GeneRIF Correction

General gene information

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Markers

Hif1an (e-PCR), detects polymorphism
- UniSTS:531397

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NF-kappaB binding	IEA Inferred from Electronic Annotation more info
enables NF-kappaB binding	ISO Inferred from Sequence Orthology more info
enables Notch binding	IEA Inferred from Electronic Annotation more info
enables Notch binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables [protein]-asparagine 3-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables [protein]-asparagine 3-dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables [protein]-asparagine 3-dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables ankyrin repeat binding	IEA Inferred from Electronic Annotation more info
enables ankyrin repeat binding	ISO Inferred from Sequence Orthology more info
enables carboxylic acid binding	IEA Inferred from Electronic Annotation more info
enables carboxylic acid binding	ISO Inferred from Sequence Orthology more info
enables ferrous iron binding	IEA Inferred from Electronic Annotation more info
enables ferrous iron binding	ISO Inferred from Sequence Orthology more info
enables peptidyl-aspartic acid 3-dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-aspartic acid 3-dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables peptidyl-histidine dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-histidine dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-histidine dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in negative regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of developmental process	IEA Inferred from Electronic Annotation more info
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of vascular endothelial growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hypoxia-inducible factor 1-alpha inhibitor

Names: hypoxia-inducible factor 1, alpha subunit inhibitor

NP_001107221.1

EC 1.14.11.16

XP_038936292.1

EC 1.14.11.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113749.1 → NP_001107221.1 hypoxia-inducible factor 1-alpha inhibitor

See identical proteins and their annotated locations for NP_001107221.1

Status: PROVISIONAL

Source sequence(s)

BC158810

UniProtKB/TrEMBL

A0A8I6G3J3, B0BNG5

Conserved Domains (1) summary

pfam13621
Location:53 → 297

Cupin_8; Cupin-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

253368400..253385495

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080364.2 → XP_038936292.1 hypoxia-inducible factor 1-alpha inhibitor isoform X1

UniProtKB/TrEMBL

B0BNG5

Related

ENSRNOP00000078637.2, ENSRNOT00000114444.2

Conserved Domains (1) summary

pfam13621
Location:53 → 297

Cupin_8; Cupin-like domain