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Abhd17b abhydrolase domain containing 17B, depalmitoylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 309399, updated on 8-Dec-2022

Summary

Official Symbol
Abhd17bprovided by RGD
Official Full Name
abhydrolase domain containing 17B, depalmitoylaseprovided by RGD
Primary source
RGD:1305246
See related
Ensembl:ENSRNOG00000012514 AllianceGenome:RGD:1305246
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cgi67l; Fam108b1; RGD1305246
Summary
Predicted to enable palmitoyl-(protein) hydrolase activity. Involved in regulation of postsynapse organization. Is active in glutamatergic synapse. Is anchored component of postsynaptic density membrane and anchored component of postsynaptic recycling endosome membrane. Orthologous to human ABHD17B (abhydrolase domain containing 17B, depalmitoylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 183.6), Brain (RPKM 176.3) and 9 other tissues See more
Orthologs
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Genomic context

See Abhd17b in Genome Data Viewer
Location:
1q51
Exon count:
5
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (219198294..219232733)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (239266140..239301133)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene similar to human chromosome 9 open reading frame 85 Neighboring gene uncharacterized LOC108348948 Neighboring gene fatty acid binding protein 5, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables palmitoyl-(protein) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables palmitoyl-(protein) hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in postsynaptic recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic recycling endosome membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
alpha/beta hydrolase domain-containing protein 17B
Names
abhydrolase domain-containing protein 17B
abhydrolase domain-containing protein FAM108B1
family with sequence similarity 108, member B1
protein ABHD17B
NP_001014050.1
XP_006231224.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014028.1NP_001014050.1  alpha/beta hydrolase domain-containing protein 17B

    See identical proteins and their annotated locations for NP_001014050.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079229
    UniProtKB/Swiss-Prot
    Q6AY17
    Related
    ENSRNOP00000047508.2, ENSRNOT00000044486.4
    Conserved Domains (1) summary
    COG1073
    Location:93285
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    219198294..219232733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231162.4XP_006231224.1  alpha/beta hydrolase domain-containing protein 17B isoform X1

    See identical proteins and their annotated locations for XP_006231224.1

    UniProtKB/Swiss-Prot
    Q6AY17
    Conserved Domains (1) summary
    COG1073
    Location:93285
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]