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Tor1b torsin family 1, member B [ Mus musculus (house mouse) ]

Gene ID: 30934, updated on 18-Sep-2024

Summary

Official Symbol
Tor1bprovided by MGI
Official Full Name
torsin family 1, member Bprovided by MGI
Primary source
MGI:MGI:1353605
See related
Ensembl:ENSMUSG00000026848 AllianceGenome:MGI:1353605
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DQ1; torsinB; 2610016F05Rik
Summary
Enables identical protein binding activity. Acts upstream of or within nuclear membrane organization. Located in endoplasmic reticulum lumen and nuclear envelope. Is expressed in several structures, including central nervous system; heart; liver; spleen; and tongue. Orthologous to human TOR1B (torsin family 1 member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 17.0), bladder adult (RPKM 14.3) and 28 other tissues See more
Orthologs
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Genomic context

See Tor1b in Genome Data Viewer
Location:
2 B; 2 21.76 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30842951..30854085)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30952939..30964073)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene prostaglandin E synthase Neighboring gene predicted gene, 52550 Neighboring gene predicted gene, 57831 Neighboring gene STARR-seq mESC enhancer starr_04126 Neighboring gene peptidylprolyl isomerase A pseudogene 2_387.1 Neighboring gene torsin family 1, member A (torsin A) Neighboring gene cDNA sequence BC005624 Neighboring gene ubiquitin specific peptidase 20 Neighboring gene predicted gene, 39786

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables kinesin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding IEA
Inferred from Electronic Annotation
more info
 
involved_in endoplasmic reticulum organization ISO
Inferred from Sequence Orthology
more info
 
involved_in endoplasmic reticulum organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in nuclear membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within nuclear membrane organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein localization to nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in endoplasmic reticulum lumen IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
torsin-1B
Names
torsin ATPase-1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133673.3NP_598434.2  torsin-1B precursor

    See identical proteins and their annotated locations for NP_598434.2

    Status: VALIDATED

    Source sequence(s)
    AK017290, AK028859, AK159843, AV283130
    Consensus CDS
    CCDS15890.1
    UniProtKB/Swiss-Prot
    Q8VEI4, Q9ER41
    Related
    ENSMUSP00000028199.6, ENSMUST00000028199.12
    Conserved Domains (2) summary
    smart00382
    Location:101244
    AAA; ATPases associated with a variety of cellular activities
    cl21455
    Location:51176
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    30842951..30854085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318972.3XP_017174461.1  torsin-1B isoform X1

    Conserved Domains (2) summary
    pfam06309
    Location:51176
    Torsin
    TIGR03345
    Location:172227
    VI_ClpV1; type VI secretion ATPase, ClpV1 family

RNA

  1. XR_374100.2 RNA Sequence

    Related
    ENSMUST00000156711.8