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Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 309295, updated on 8-Dec-2022

Summary

Official Symbol
Ikbkgprovided by RGD
Official Full Name
inhibitor of nuclear factor kappa B kinase regulatory subunit gammaprovided by RGD
Primary source
RGD:735223
See related
Ensembl:ENSRNOG00000060936 AllianceGenome:RGD:735223
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nemo
Summary
Enables peroxisome proliferator activated receptor binding activity. Predicted to be involved in several processes, including anoikis; regulation of gene expression; and regulation of signal transduction. Predicted to act upstream of or within B cell homeostasis and activation of NF-kappaB-inducing kinase activity. Located in cytosol. Part of IkappaB kinase complex. Used to study irritable bowel syndrome and perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in Behcet's disease; Bloch-Sulzberger syndrome; immunodeficiency 33; and learning disability. Orthologous to human IKBKG (inhibitor of nuclear factor kappa B kinase regulatory subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 113.2), Thymus (RPKM 84.4) and 9 other tissues See more
Orthologs
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Genomic context

See Ikbkg in Genome Data Viewer
Location:
Xq37
Exon count:
14
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (152216485..152241476)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (156254187..156280046, complement)

Chromosome X - NC_051356.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 10, member 3 Neighboring gene FAM3 metabolism regulating signaling molecule A Neighboring gene glucose-6-phosphate dehydrogenase Neighboring gene uncharacterized LOC120099296 Neighboring gene uncharacterized LOC120099237 Neighboring gene similar to ESO3 protein

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables K63-linked polyubiquitin modification-dependent protein binding IEA
Inferred from Electronic Annotation
more info
 
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables K63-linked polyubiquitin modification-dependent protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables linear polyubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
enables linear polyubiquitin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peroxisome proliferator activated receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within activation of NF-kappaB-inducing kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in anoikis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to DNA damage stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in establishment of vesicle localization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of IkappaB kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of IkappaB kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of IkappaB kinase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NF-kappa-B essential modulator
Names
I-kappa-B kinase gamma
I-kappa-B kinase subunit gamma
IKK-gamma
IKKAP1
IKKG
NF-kappa-B essential modifier
ikB kinase subunit gamma
ikB kinase-associated protein 1
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
inhibitor of kappaB kinase gamma
inhibitor of nuclear factor kappa B kinase subunit gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199103.2NP_954534.1  NF-kappa-B essential modulator

    See identical proteins and their annotated locations for NP_954534.1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000491
    UniProtKB/Swiss-Prot
    Q6TMG5
    Conserved Domains (3) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:170280
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl15254
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051356.1 Reference mRatBN7.2 Primary Assembly

    Range
    152216485..152241476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008773600.3XP_008771822.1  NF-kappa-B essential modulator isoform X1

    See identical proteins and their annotated locations for XP_008771822.1

    Conserved Domains (3) summary
    cd09803
    Location:270356
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:62129
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:189299
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  2. XM_008773603.3XP_008771825.1  NF-kappa-B essential modulator isoform X1

    See identical proteins and their annotated locations for XP_008771825.1

    Conserved Domains (3) summary
    cd09803
    Location:270356
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:62129
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:189299
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  3. XM_008773602.3XP_008771824.1  NF-kappa-B essential modulator isoform X1

    See identical proteins and their annotated locations for XP_008771824.1

    Conserved Domains (3) summary
    cd09803
    Location:270356
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:62129
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:189299
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  4. XM_008773601.3XP_008771823.1  NF-kappa-B essential modulator isoform X1

    See identical proteins and their annotated locations for XP_008771823.1

    Conserved Domains (3) summary
    cd09803
    Location:270356
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:62129
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:189299
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  5. XM_008773605.3XP_008771827.1  NF-kappa-B essential modulator isoform X3

    Conserved Domains (3) summary
    cd09803
    Location:269355
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:62129
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:188298
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  6. XM_008773606.3XP_008771828.1  NF-kappa-B essential modulator isoform X4

    Conserved Domains (3) summary
    cd09803
    Location:268354
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:62129
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:187297
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  7. XM_008773607.3XP_008771829.1  NF-kappa-B essential modulator isoform X5

    See identical proteins and their annotated locations for XP_008771829.1

    Conserved Domains (3) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:171281
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl15254
    Location:252338
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  8. XM_008773604.3XP_008771826.1  NF-kappa-B essential modulator isoform X2

    See identical proteins and their annotated locations for XP_008771826.1

    UniProtKB/TrEMBL
    A0A8I6AH74
    Conserved Domains (3) summary
    cd09803
    Location:269355
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:62129
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:188298
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  9. XM_006229580.4XP_006229642.1  NF-kappa-B essential modulator isoform X2

    See identical proteins and their annotated locations for XP_006229642.1

    UniProtKB/TrEMBL
    A0A8I6AH74
    Related
    ENSRNOP00000092097.1, ENSRNOT00000107762.1
    Conserved Domains (3) summary
    cd09803
    Location:269355
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam11577
    Location:62129
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:188298
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  10. XM_008773608.3XP_008771830.1  NF-kappa-B essential modulator isoform X5

    See identical proteins and their annotated locations for XP_008771830.1

    Conserved Domains (3) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:171281
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl15254
    Location:252338
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  11. XM_006229584.4XP_006229646.1  NF-kappa-B essential modulator isoform X6

    UniProtKB/Swiss-Prot
    Q6TMG5
    Conserved Domains (3) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:170280
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl15254
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  12. XM_008773610.3XP_008771832.1  NF-kappa-B essential modulator isoform X5

    See identical proteins and their annotated locations for XP_008771832.1

    Conserved Domains (3) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:171281
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl15254
    Location:252338
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  13. XM_006229585.4XP_006229647.1  NF-kappa-B essential modulator isoform X6

    See identical proteins and their annotated locations for XP_006229647.1

    UniProtKB/Swiss-Prot
    Q6TMG5
    Related
    ENSRNOP00000075158.2, ENSRNOT00000078438.2
    Conserved Domains (3) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:170280
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl15254
    Location:251337
    UBAN; polyubiquitin binding domain of NEMO and related proteins
  14. XM_017602025.2XP_017457514.1  NF-kappa-B essential modulator isoform X5

    Conserved Domains (3) summary
    pfam11577
    Location:44111
    NEMO; NF-kappa-B essential modulator NEMO
    cl00459
    Location:171281
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl15254
    Location:252338
    UBAN; polyubiquitin binding domain of NEMO and related proteins