Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ikbkgprovided by RGD
Official Full Name: inhibitor of nuclear factor kappa B kinase regulatory subunit gammaprovided by RGD
Primary source: RGD:735223
See related: Ensembl:ENSRNOG00000060936 AllianceGenome:RGD:735223
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nemo
Summary: Enables peroxisome proliferator activated receptor binding activity. Predicted to be involved in several processes, including anoikis; regulation of gene expression; and regulation of signal transduction. Predicted to act upstream of or within B cell homeostasis and activation of NF-kappaB-inducing kinase activity. Located in cytosol. Part of IkappaB kinase complex. Used to study irritable bowel syndrome and perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in Behcet's disease; Bloch-Sulzberger syndrome; immunodeficiency 33; and learning disability. Orthologous to human IKBKG (inhibitor of nuclear factor kappa B kinase regulatory subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 113.2), Thymus (RPKM 84.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq37

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
108	current	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (152216485..152241476)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (156254187..156280046, complement)

Chromosome X - NC_051356.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that most NEMO molecules do not form a tripartite IKK complex with IKKalpha-IKKbeta heterodimer as previously reported in the literature but, instead, NEMO is able to form a complex with the monomeric forms of IKKalpha and IKKbeta.
Title: NEMO oligomerization in the dynamic assembly of the IkappaB kinase core complex.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AF069542 (e-PCR)
- UniSTS:163621

RH134438 (e-PCR)
- UniSTS:217718

Homology

Homologs of the Ikbkg gene: The Ikbkg gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, zebrafish, and frog.
Orthologs from Annotation Pipeline: 238 organisms have orthologs with human gene Ikbkg
Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables K63-linked polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables K63-linked polyubiquitin modification-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables K63-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables K63-linked polyubiquitin modification-dependent protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables linear polyubiquitin binding	ISO Inferred from Sequence Orthology more info
enables linear polyubiquitin binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peroxisome proliferator activated receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferrin receptor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within activation of NF-kappaB-inducing kinase activity	ISO Inferred from Sequence Orthology more info
involved_in anoikis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to DNA damage stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to DNA damage stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of vesicle localization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of IkappaB kinase complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of IkappaB kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of IkappaB kinase complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NF-kappa-B essential modulator

Names: I-kappa-B kinase gamma; I-kappa-B kinase subunit gamma; IKK-gamma; IKKAP1; IKKG; NF-kappa-B essential modifier; ikB kinase subunit gamma; ikB kinase-associated protein 1; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; inhibitor of kappaB kinase gamma; inhibitor of nuclear factor kappa B kinase subunit gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199103.2 → NP_954534.1 NF-kappa-B essential modulator

See identical proteins and their annotated locations for NP_954534.1

Status: VALIDATED

Source sequence(s)

JACYVU010000491

UniProtKB/Swiss-Prot

Q6TMG5

Conserved Domains (3) summary

pfam11577
Location:44 → 111

NEMO; NF-kappa-B essential modulator NEMO

cl00459
Location:170 → 280

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl15254
Location:251 → 337

UBAN; polyubiquitin binding domain of NEMO and related proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

NC_051356.1 Reference mRatBN7.2 Primary Assembly

Range

152216485..152241476

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008773600.3 → XP_008771822.1 NF-kappa-B essential modulator isoform X1

See identical proteins and their annotated locations for XP_008771822.1

Conserved Domains (3) summary

cd09803
Location:270 → 356

UBAN; polyubiquitin binding domain of NEMO and related proteins

pfam11577
Location:62 → 129

NEMO; NF-kappa-B essential modulator NEMO

cl00459
Location:189 → 299

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
XM_008773603.3 → XP_008771825.1 NF-kappa-B essential modulator isoform X1

See identical proteins and their annotated locations for XP_008771825.1

Conserved Domains (3) summary

cd09803
Location:270 → 356

UBAN; polyubiquitin binding domain of NEMO and related proteins

pfam11577
Location:62 → 129

NEMO; NF-kappa-B essential modulator NEMO

cl00459
Location:189 → 299

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
XM_008773602.3 → XP_008771824.1 NF-kappa-B essential modulator isoform X1

See identical proteins and their annotated locations for XP_008771824.1

Conserved Domains (3) summary

cd09803
Location:270 → 356

UBAN; polyubiquitin binding domain of NEMO and related proteins

pfam11577
Location:62 → 129

NEMO; NF-kappa-B essential modulator NEMO

cl00459
Location:189 → 299

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
XM_008773601.3 → XP_008771823.1 NF-kappa-B essential modulator isoform X1

See identical proteins and their annotated locations for XP_008771823.1

Conserved Domains (3) summary

cd09803
Location:270 → 356

UBAN; polyubiquitin binding domain of NEMO and related proteins

pfam11577
Location:62 → 129

NEMO; NF-kappa-B essential modulator NEMO

cl00459
Location:189 → 299

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
XM_008773605.3 → XP_008771827.1 NF-kappa-B essential modulator isoform X3

Conserved Domains (3) summary

cd09803
Location:269 → 355

UBAN; polyubiquitin binding domain of NEMO and related proteins

pfam11577
Location:62 → 129

NEMO; NF-kappa-B essential modulator NEMO

cl00459
Location:188 → 298

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
XM_008773606.3 → XP_008771828.1 NF-kappa-B essential modulator isoform X4

Conserved Domains (3) summary

cd09803
Location:268 → 354

UBAN; polyubiquitin binding domain of NEMO and related proteins

pfam11577
Location:62 → 129

NEMO; NF-kappa-B essential modulator NEMO

cl00459
Location:187 → 297

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
XM_008773607.3 → XP_008771829.1 NF-kappa-B essential modulator isoform X5

See identical proteins and their annotated locations for XP_008771829.1

Conserved Domains (3) summary

pfam11577
Location:44 → 111

NEMO; NF-kappa-B essential modulator NEMO

cl00459
Location:171 → 281

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl15254
Location:252 → 338

UBAN; polyubiquitin binding domain of NEMO and related proteins
XM_008773604.3 → XP_008771826.1 NF-kappa-B essential modulator isoform X2

See identical proteins and their annotated locations for XP_008771826.1

UniProtKB/TrEMBL

A0A8I6AH74

Conserved Domains (3) summary

cd09803
Location:269 → 355

UBAN; polyubiquitin binding domain of NEMO and related proteins

pfam11577
Location:62 → 129

NEMO; NF-kappa-B essential modulator NEMO

cl00459
Location:188 → 298

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
XM_006229580.4 → XP_006229642.1 NF-kappa-B essential modulator isoform X2

See identical proteins and their annotated locations for XP_006229642.1

UniProtKB/TrEMBL

A0A8I6AH74

Related

ENSRNOP00000092097.1, ENSRNOT00000107762.1

Conserved Domains (3) summary

cd09803
Location:269 → 355

UBAN; polyubiquitin binding domain of NEMO and related proteins

pfam11577
Location:62 → 129

NEMO; NF-kappa-B essential modulator NEMO

cl00459
Location:188 → 298

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
XM_008773608.3 → XP_008771830.1 NF-kappa-B essential modulator isoform X5

See identical proteins and their annotated locations for XP_008771830.1

Conserved Domains (3) summary

pfam11577
Location:44 → 111

NEMO; NF-kappa-B essential modulator NEMO

cl00459
Location:171 → 281

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl15254
Location:252 → 338

UBAN; polyubiquitin binding domain of NEMO and related proteins
XM_006229584.4 → XP_006229646.1 NF-kappa-B essential modulator isoform X6

UniProtKB/Swiss-Prot

Q6TMG5

Conserved Domains (3) summary

pfam11577
Location:44 → 111

NEMO; NF-kappa-B essential modulator NEMO

cl00459
Location:170 → 280

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl15254
Location:251 → 337

UBAN; polyubiquitin binding domain of NEMO and related proteins
XM_008773610.3 → XP_008771832.1 NF-kappa-B essential modulator isoform X5

See identical proteins and their annotated locations for XP_008771832.1

Conserved Domains (3) summary

pfam11577
Location:44 → 111

NEMO; NF-kappa-B essential modulator NEMO

cl00459
Location:171 → 281

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl15254
Location:252 → 338

UBAN; polyubiquitin binding domain of NEMO and related proteins
XM_006229585.4 → XP_006229647.1 NF-kappa-B essential modulator isoform X6

See identical proteins and their annotated locations for XP_006229647.1

UniProtKB/Swiss-Prot

Q6TMG5

Related

ENSRNOP00000075158.2, ENSRNOT00000078438.2

Conserved Domains (3) summary

pfam11577
Location:44 → 111

NEMO; NF-kappa-B essential modulator NEMO

cl00459
Location:170 → 280

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl15254
Location:251 → 337

UBAN; polyubiquitin binding domain of NEMO and related proteins
XM_017602025.2 → XP_017457514.1 NF-kappa-B essential modulator isoform X5

Conserved Domains (3) summary

pfam11577
Location:44 → 111

NEMO; NF-kappa-B essential modulator NEMO

cl00459
Location:171 → 281

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl15254
Location:252 → 338

UBAN; polyubiquitin binding domain of NEMO and related proteins