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Plxna3 plexin A3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309280, updated on 2-Oct-2018

Summary

Official Symbol
Plxna3provided by RGD
Official Full Name
plexin A3provided by RGD
Primary source
RGD:1584973
See related
Ensembl:ENSRNOG00000060464
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SEX; Plxn4
Expression
Biased expression in Brain (RPKM 35.9), Adrenal (RPKM 33.6) and 9 other tissues See more
Orthologs

Genomic context

See Plxna3 in Genome Data Viewer
Location:
Xq37
Exon count:
34
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (156363400..156379433, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (152103535..152119342, complement)

Chromosome X - NC_005120.4Genomic Context describing neighboring genes Neighboring gene ubiquitin-like 4A Neighboring gene L antigen family, member 3 Neighboring gene uncharacterized LOC102548378 Neighboring gene family with sequence similarity 50, member A

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
semaphorin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
semaphorin receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
axon guidance ISO
Inferred from Sequence Orthology
more info
 
branchiomotor neuron axon guidance IEA
Inferred from Electronic Annotation
more info
 
branchiomotor neuron axon guidance ISO
Inferred from Sequence Orthology
more info
 
facial nerve structural organization IEA
Inferred from Electronic Annotation
more info
 
facial nerve structural organization ISO
Inferred from Sequence Orthology
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
hippocampus development ISO
Inferred from Sequence Orthology
more info
 
negative chemotaxis IEA
Inferred from Electronic Annotation
more info
 
negative chemotaxis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of axon extension involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 
negative regulation of axon extension involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection extension IEA
Inferred from Electronic Annotation
more info
 
neuron projection extension ISO
Inferred from Sequence Orthology
more info
 
neuron projection guidance ISO
Inferred from Sequence Orthology
more info
 
positive regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
pyramidal neuron development IEA
Inferred from Electronic Annotation
more info
 
pyramidal neuron development ISO
Inferred from Sequence Orthology
more info
 
regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
semaphorin-plexin signaling pathway involved in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
semaphorin-plexin signaling pathway involved in axon guidance ISO
Inferred from Sequence Orthology
more info
 
trigeminal nerve structural organization IEA
Inferred from Electronic Annotation
more info
 
trigeminal nerve structural organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell junction ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
semaphorin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
plexin-A3
Names
Plexin 4, SEX, homolog to the cMet/HGF receptors

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107581.2NP_001101051.2  plexin-A3 precursor

    See identical proteins and their annotated locations for NP_001101051.2

    Status: PROVISIONAL

    Source sequence(s)
    AC094668
    UniProtKB/Swiss-Prot
    D3ZPX4
    Related
    ENSRNOP00000068735.1, ENSRNOT00000083148.1
    Conserved Domains (8) summary
    cd11273
    Location:22490
    Sema_plexin_A3; The Sema domain, a protein interacting module, of Plexin A3
    smart00423
    Location:638685
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00603
    Location:11261209
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:9361022
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:841935
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:10241124
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:491531
    PSI; Plexin repeat
    pfam08337
    Location:12951842
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005120.4 Reference Rnor_6.0 Primary Assembly

    Range
    156363400..156379433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017602023.1XP_017457512.1  plexin-A3 isoform X3

    UniProtKB/Swiss-Prot
    D3ZPX4
  2. XM_006229577.3XP_006229639.1  plexin-A3 isoform X3

    See identical proteins and their annotated locations for XP_006229639.1

    UniProtKB/Swiss-Prot
    D3ZPX4
    Conserved Domains (8) summary
    cd11273
    Location:22490
    Sema_plexin_A3; The Sema domain, a protein interacting module, of Plexin A3
    smart00423
    Location:638685
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00603
    Location:11261209
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:9361022
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:841935
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:10241124
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:491531
    PSI; Plexin repeat
    pfam08337
    Location:12951842
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
  3. XM_008773599.2XP_008771821.1  plexin-A3 isoform X2

    Conserved Domains (7) summary
    cd11273
    Location:108576
    Sema_plexin_A3; The Sema domain, a protein interacting module, of Plexin A3
    smart00423
    Location:724771
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:10221108
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:9271021
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:577617
    PSI; Plexin repeat
    pfam08337
    Location:13041851
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    cl15674
    Location:11101197
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  4. XM_008773598.2XP_008771820.1  plexin-A3 isoform X1

    Conserved Domains (8) summary
    cd11273
    Location:108576
    Sema_plexin_A3; The Sema domain, a protein interacting module, of Plexin A3
    smart00423
    Location:724771
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd00603
    Location:12121295
    IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...
    cd01179
    Location:10221108
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:9271021
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:11101210
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:577617
    PSI; Plexin repeat
    pfam08337
    Location:13811928
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    135765043..135780832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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