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Fan1 FANCD2 and FANCI associated nuclease 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 309256, updated on 3-Jun-2026
Official Symbol
Fan1provided by RGD
Official Full Name
FANCD2 and FANCI associated nuclease 1provided by RGD
Primary source
RGD:1566323
See related
Ensembl:ENSRNOG00000023985 AllianceGenome:RGD:1566323
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mtmr15; RGD1566323
Summary
Predicted to enable flap-structured DNA binding activity; nuclease activity; and ubiquitin-modified protein reader activity. Predicted to be involved in double-strand break repair via homologous recombination; interstrand cross-link repair; and nucleotide-excision repair. Predicted to be located in several cellular components, including cilium; intercellular bridge; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in karyomegalic interstitial nephritis. Orthologous to human FAN1 (FANCD2 and FANCI associated nuclease 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Kidney (RPKM 43.3), Heart (RPKM 39.6) and 9 other tissues See more
Orthologs
all
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See Fan1 in Genome Data Viewer
Location:
1q22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (127327098..127356807, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (117915323..117945044, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (125182117..125209772, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily M, member 1 Neighboring gene microRNA 211 Neighboring gene myotubularin related protein 10 Neighboring gene M-phase phosphoprotein 10 Neighboring gene methylmalonyl CoA epimerase

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1. Wang R, et al. Science, 2014 Nov 28. PMID 25430771, Free PMC Article
  2. Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents. Kratz K, et al. Cell, 2010 Jul 9. PMID 20603016
  3. A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. Smogorzewska A, et al. Mol Cell, 2010 Jul 9. PMID 20603073, Free PMC Article
  4. Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. MacKay C, et al. Cell, 2010 Jul 9. PMID 20603015, Free PMC Article
  5. FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain. Pennell S, et al. Cell Rep, 2014 Jul 10. PMID 24981866, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 5'-3' exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-3' exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables 5'-3' exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables 5'-flap endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-flap endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables flap-structured DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flap-structured DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphodiesterase I activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphodiesterase I activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-modified protein reader activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in interstrand cross-link repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interstrand cross-link repair IEA
Inferred from Electronic Annotation
more info
  
involved_in interstrand cross-link repair ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
fanconi-associated nuclease 1
Names
FANCD2/FANCI-associated nuclease 1
coiled-coil domain-containing protein MTMR15
myotubularin related protein 15
NP_001178562.1
XP_006229401.1
XP_038935867.1
XP_038935871.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191633.2 → NP_001178562.1  fanconi-associated nuclease 1 isoform 1

    See identical proteins and their annotated locations for NP_001178562.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    D3ZVU2
    Related
    ENSRNOP00000032711.5, ENSRNOT00000031067.8
    Conserved Domains (1) summary
    smart00990
    Location:896 → 1011
    VRR_NUC; This model contains proteins with the VRR-NUC domain

  2. NM_001438031.1 → NP_001424960.1  fanconi-associated nuclease 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0ABK0LSB1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    127327098..127356807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079939.2 → XP_038935867.1  

    Related
    ENSRNOP00000108052.1, ENSRNOT00000153705.1
    Conserved Domains (1) summary
    cd22326
    Location:376 → 965
    FAN1-like; repair nuclease FAN1

  2. XM_006229339.5 → XP_006229401.1  

    Conserved Domains (1) summary
    smart00990
    Location:896 → 1011
    VRR_NUC; This model contains proteins with the VRR-NUC domain

  3. XM_039079943.2 → XP_038935871.1  fanconi-associated nuclease 1 isoform X3

    UniProtKB/TrEMBL
    A6JBL0
    Conserved Domains (1) summary
    cd22326
    Location:376 → 724
    FAN1-like; repair nuclease FAN1
Nucleotide Protein Strain
Heading Accession and Version

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