Klhl35 kelch-like family member 35 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klhl35provided by RGD
Official Full Name: kelch-like family member 35provided by RGD
Primary source: RGD:1565895
See related: Ensembl:ENSRNOG00000017365 AllianceGenome:RGD:1565895
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565895
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHL35 (kelch like family member 35). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Adrenal (RPKM 8.5), Brain (RPKM 5.4) and 9 other tissues See more
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (163172811..163185663)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (153767138..153773550)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (164419052..164431055)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_218953.8 → XP_218953.4 kelch-like protein 35 isoform X1

UniProtKB/TrEMBL

A0ABK0LIA3, D4A6V5

Related

ENSRNOP00000110641.1, ENSRNOT00000150192.1

Conserved Domains (6) summary

smart00612
Location:396 → 442

Kelch; Kelch domain

smart00225
Location:51 → 151

BTB; Broad-Complex, Tramtrack and Bric a brac

sd00038
Location:341 → 381

Kelch; KELCH repeat [structural motif]

pfam00651
Location:40 → 147

BTB; BTB/POZ domain

pfam01344
Location:340 → 381

Kelch_1; Kelch motif

pfam07707
Location:173 → 258

BACK; BTB And C-terminal Kelch
XM_039101100.2 → XP_038957028.1 kelch-like protein 35 isoform X2

UniProtKB/TrEMBL

D4A6V5