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Lrrk1 leucine-rich repeat kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308703, updated on 3-Jun-2026
Official Symbol
Lrrk1provided by RGD
Official Full Name
leucine-rich repeat kinase 1provided by RGD
Primary source
RGD:1308000
See related
Ensembl:ENSRNOG00000012730 AllianceGenome:RGD:1308000
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and protein kinase activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway and signal transduction. Predicted to act upstream of or within several processes, including bone resorption; osteoclast development; and regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in cytosol and mitochondrion. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in osteosclerotic metaphyseal dysplasia. Orthologous to human LRRK1 (leucine rich repeat kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Spleen (RPKM 75.2), Lung (RPKM 63.8) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Lrrk1 in Genome Data Viewer
Location:
1q22
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (129254815..129390217, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (119844360..119972885, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (127166866..127301053, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485128 Neighboring gene uncharacterized LOC134485130 Neighboring gene uncharacterized LOC134485129 Neighboring gene uncharacterized LOC102549616 Neighboring gene small nucleolar RNA SNORA40 Neighboring gene aldehyde dehydrogenase 1 family, member A3 Neighboring gene transfer RNA proline (anticodon AGG) 55

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson's disease. Westerlund M, et al. Neuroscience, 2008 Mar 18. PMID 18272292
  2. Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis. Xing W, et al. J Bone Miner Res, 2013 Sep. PMID 23526378, Free PMC Article
  3. Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers. Civiero L, et al. PLoS One, 2012. PMID 22952686, Free PMC Article
  4. Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment. Klein CL, et al. J Neurochem, 2009 Nov. PMID 19712061
  5. LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6. Berwick DC, et al. Hum Mol Genet, 2012 Nov 15. PMID 22899650, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lrrk1 is found in many areas of the P1 rat. Lrrk1 is present in adult rat brain, adrenal gland, liver, lung, spleen and kidney and also in embryonic brain, with declining gene activity after birth.
    Title: Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson's disease.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bone resorption ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within osteoclast development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
leucine-rich repeat serine/threonine-protein kinase 1
NP_001178553.1
XP_038968616.1
XP_063118546.1
XP_063118548.1
XP_063118551.1
XP_063118560.1
XP_063118568.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191624.2 → NP_001178553.1  leucine-rich repeat serine/threonine-protein kinase 1

    See identical proteins and their annotated locations for NP_001178553.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6B1B9
    Related
    ENSRNOP00000094655.2, ENSRNOT00000106564.2
    Conserved Domains (11) summary
    smart00220
    Location:1247 → 1511
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1100
    Location:635 → 781
    Gem1; GTPase SAR1 family domain [General function prediction only]
    COG4886
    Location:279 → 513
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:273 → 464
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd00204
    Location:91 → 214
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14067
    Location:1248 → 1523
    STKc_LRRK1; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1
    sd00033
    Location:281 → 303
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12796
    Location:126 → 221
    Ank_2; Ankyrin repeats (3 copies)
    pfam16095
    Location:844 → 1036
    COR; C-terminal of Roc, COR, domain
    sd00045
    Location:156 → 186
    ANK; ANK repeat [structural motif]
    cl21455
    Location:639 → 821
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    129254815..129390217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262481.1 → XP_063118551.1  leucine-rich repeat serine/threonine-protein kinase 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6B1B9

  2. XM_063262476.1 → XP_063118546.1  

    Related
    ENSRNOP00000016959.7, ENSRNOT00000016959.8

  3. XM_063262478.1 → XP_063118548.1  leucine-rich repeat serine/threonine-protein kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6B1B9

  4. XM_039112688.2 → XP_038968616.1  leucine-rich repeat serine/threonine-protein kinase 1 isoform X5

    Conserved Domains (3) summary
    cd14067
    Location:543 → 818
    STKc_LRRK1; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1
    pfam16095
    Location:139 → 331
    COR; C-terminal of Roc, COR, domain
    cl38936
    Location:6 → 116
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. XM_063262490.1 → XP_063118560.1  leucine-rich repeat serine/threonine-protein kinase 1 isoform X3

  6. XM_063262498.1 → XP_063118568.1  leucine-rich repeat serine/threonine-protein kinase 1 isoform X4

RNA

  1. XR_010052148.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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