Klk14 kallikrein related-peptidase 14 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klk14provided by RGD
Official Full Name: kallikrein related-peptidase 14provided by RGD
Primary source: RGD:1308606
See related: Ensembl:ENSRNOG00000033706 AllianceGenome:RGD:1308606
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Klnm
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including epidermis morphogenesis; regulation of G protein-coupled receptor signaling pathway; and seminal clot liquefaction. Predicted to be active in extracellular space and secretory granule. Orthologous to human KLK14 (kallikrein related peptidase 14). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Uterus (RPKM 15.6), Lung (RPKM 5.2) and 2 other tissues See more
Orthologs: all
: Try the new Gene page
Try the new Transcripts and proteins table

Genomic context

Location:: 1q22

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (103258327..103273792)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (94123131..94137239)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KLK8 and KLK14 can signal differentially via the PARs to affect tissue function
Title:

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in epidermis morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in fertilization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in seminal clot liquefaction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: kallikrein-14

Names: kallikrein 14; kallikrein m

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427330.1 → NP_001414259.1 kallikrein-14 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A1R3UCJ8, F1M091

Related

ENSRNOP00000111204.1, ENSRNOT00000172147.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

103258327..103273792

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039100912.2 → XP_038956840.1 kallikrein-14 isoform X1

UniProtKB/TrEMBL

F1M091

Related

ENSRNOP00000032634.6, ENSRNOT00000029197.7

Conserved Domains (1) summary

cd00190
Location:84 → 306

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_063261757.1 → XP_063117827.1 kallikrein-14 isoform X2

UniProtKB/TrEMBL

A0A1R3UCJ8, F1M091