Format

Send to:

Choose Destination

TAX1BP3 Tax1 binding protein 3 [ Homo sapiens (human) ]

Gene ID: 30851, updated on 13-Mar-2020

Summary

Official Symbol
TAX1BP3provided by HGNC
Official Full Name
Tax1 binding protein 3provided by HGNC
Primary source
HGNC:HGNC:30684
See related
Ensembl:ENSG00000213977 MIM:616484
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIP1; TIP-1
Summary
This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]
Expression
Ubiquitous expression in stomach (RPKM 62.9), endometrium (RPKM 61.2) and 25 other tissues See more
Orthologs

Genomic context

See TAX1BP3 in Genome Data Viewer
Location:
17p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (3662893..3668679, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3566187..3571973, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371493 Neighboring gene cystinosin, lysosomal cystine transporter Neighboring gene uncharacterized LOC105371492 Neighboring gene P2RX5-TAX1BP3 readthrough (NMD candidate) Neighboring gene ribosomal protein L21 pseudogene 125 Neighboring gene ER membrane protein complex subunit 6 Neighboring gene purinergic receptor P2X 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough P2RX5-TAX1BP3

Readthrough gene: P2RX5-TAX1BP3, Included gene: P2RX5

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rho protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein localization to cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein localization to cell surface IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
fibrillar center IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tax1-binding protein 3
Names
Tax interaction protein 1
Tax1 (human T-cell leukemia virus type I) binding protein 3
glutaminase-interacting protein 3
tax-interacting protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053154.1 RefSeqGene

    Range
    5102..10785
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001204698.1NP_001191627.1  tax1-binding protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001191627.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AF028823, AF277318, BM973411, CB129195
    Consensus CDS
    CCDS73940.1
    UniProtKB/Swiss-Prot
    O14907
    UniProtKB/TrEMBL
    A0A087X282
    Related
    ENSP00000484776.1, ENST00000611779.4
    Conserved Domains (1) summary
    cl00117
    Location:1383
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
  2. NM_014604.4NP_055419.1  tax1-binding protein 3 isoform 1

    See identical proteins and their annotated locations for NP_055419.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF028823, AF277318, BM973411
    Consensus CDS
    CCDS11032.1
    UniProtKB/Swiss-Prot
    O14907
    Related
    ENSP00000225525.3, ENST00000225525.4
    Conserved Domains (1) summary
    cd00992
    Location:13109
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    3662893..3668679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center