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Cd22 CD22 molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 308501, updated on 5-Sep-2025
Official Symbol
Cd22provided by RGD
Official Full Name
CD22 moleculeprovided by RGD
Primary source
RGD:1311610
See related
Ensembl:ENSRNOG00000024000 AllianceGenome:RGD:1311610
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable CD4 receptor binding activity; protein phosphatase binding activity; and sialic acid binding activity. Predicted to be involved in several processes, including negative regulation of immunoglobulin production; negative regulation of signal transduction; and regulation of B cell proliferation. Predicted to be located in cell surface and neuronal cell body membrane. Predicted to be active in early endosome; external side of plasma membrane; and recycling endosome. Human ortholog(s) of this gene implicated in diffuse large B-cell lymphoma. Orthologous to human CD22 (CD22 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Spleen (RPKM 371.2), Thymus (RPKM 52.3) and 1 other tissue See more
Orthologs
human mouse all
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See Cd22 in Genome Data Viewer
Location:
1q21
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95243785..95270430, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (86116376..86132782, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89313475..89329902, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene free fatty acid receptor 3 Neighboring gene free fatty acid receptor 1 Neighboring gene uncharacterized LOC108349549 Neighboring gene uncharacterized LOC120099789 Neighboring gene myelin-associated glycoprotein

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Anti-CD22 and anti-CD79B antibody drug conjugates are active in different molecular diffuse large B-cell lymphoma subtypes. Pfeifer M, et al. Leukemia, 2015 Jul. PMID 25708834
  2. Chemopreventive property of a soybean peptide (lunasin) that binds to deacetylated histones and inhibits acetylation. Galvez AF, et al. Cancer Res, 2001 Oct 15. PMID 11606382
  3. MicroRNA-19a and CD22 Comprise a Feedback Loop for B Cell Response in Sepsis. Jiang Y, et al. Med Sci Monit, 2015 May 28. PMID 26017478, Free PMC Article
  4. CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity. Jellusova J, et al. J Immunol, 2010 Apr 1. PMID 20200274
  5. Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity. Tateno H, et al. Mol Cell Biol, 2007 Aug. PMID 17562860, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables CD4 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables CD4 receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables sialic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sialic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in B cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in B cell activation IEA
Inferred from Electronic Annotation
more info
  
involved_in B cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of immunoglobulin production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of B cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of immune response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
  
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
B-cell receptor CD22
Names
CD22 antigen

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107503.1 → NP_001100973.1  B-cell receptor CD22 precursor

    See identical proteins and their annotated locations for NP_001100973.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473979
    UniProtKB/TrEMBL
    A6JA30, D3ZD88
    Related
    ENSRNOP00000031661.4, ENSRNOT00000033155.7
    Conserved Domains (5) summary
    smart00408
    Location:350 → 408
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:610 → 682
    IG; Immunoglobulin
    cd00096
    Location:24 → 28
    Ig; Ig strand A [structural motif]
    cd20938
    Location:147 → 242
    IgC1_CD22_d2; Second immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the Constant 1 (C1)-set of IgSF domains
    cl11960
    Location:24 → 143
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    95243785..95270430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261594.1 → XP_063117664.1  B-cell receptor CD22 isoform X1

  2. XM_006228828.5 → XP_006228890.1  B-cell receptor CD22 isoform X1

    See identical proteins and their annotated locations for XP_006228890.1

    UniProtKB/TrEMBL
    A6JA30, D3ZD88
    Conserved Domains (5) summary
    smart00408
    Location:350 → 408
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:610 → 682
    IG; Immunoglobulin
    cd00096
    Location:24 → 28
    Ig; Ig strand A [structural motif]
    cd20938
    Location:147 → 242
    IgC1_CD22_d2; Second immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the Constant 1 (C1)-set of IgSF domains
    cl11960
    Location:24 → 143
    Ig; Immunoglobulin domain

  3. XM_039111593.2 → XP_038967521.1  B-cell receptor CD22 isoform X1

    UniProtKB/TrEMBL
    A6JA30, D3ZD88
    Conserved Domains (5) summary
    smart00408
    Location:350 → 408
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:610 → 682
    IG; Immunoglobulin
    cd00096
    Location:24 → 28
    Ig; Ig strand A [structural motif]
    cd20938
    Location:147 → 242
    IgC1_CD22_d2; Second immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the Constant 1 (C1)-set of IgSF domains
    cl11960
    Location:24 → 143
    Ig; Immunoglobulin domain

  4. XM_008759154.4 → XP_008757376.1  B-cell receptor CD22 isoform X2

    Related
    ENSRNOP00000106657.1, ENSRNOT00000133006.1
    Conserved Domains (6) summary
    smart00408
    Location:350 → 408
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:523 → 594
    IG_like; Immunoglobulin like
    pfam07679
    Location:246 → 332
    I-set; Immunoglobulin I-set domain
    pfam13895
    Location:248 → 332
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:605 → 668
    Ig_3; Immunoglobulin domain
    cl11960
    Location:149 → 228
    Ig; Immunoglobulin domain

  5. XM_008759153.4 → XP_008757375.1  B-cell receptor CD22 isoform X1

    See identical proteins and their annotated locations for XP_008757375.1

    UniProtKB/TrEMBL
    A6JA30, D3ZD88
    Conserved Domains (5) summary
    smart00408
    Location:350 → 408
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:610 → 682
    IG; Immunoglobulin
    cd00096
    Location:24 → 28
    Ig; Ig strand A [structural motif]
    cd20938
    Location:147 → 242
    IgC1_CD22_d2; Second immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the Constant 1 (C1)-set of IgSF domains
    cl11960
    Location:24 → 143
    Ig; Immunoglobulin domain

  6. XM_063261598.1 → XP_063117668.1  B-cell receptor CD22 isoform X3

  7. XM_039111597.2 → XP_038967525.1  B-cell receptor CD22 isoform X4

    Conserved Domains (5) summary
    smart00408
    Location:350 → 408
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:610 → 682
    IG_like; Immunoglobulin like
    cd00096
    Location:24 → 28
    Ig; Ig strand A [structural motif]
    cd20938
    Location:147 → 242
    IgC1_CD22_d2; Second immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the Constant 1 (C1)-set of IgSF domains
    cl11960
    Location:24 → 143
    Ig; Immunoglobulin domain

RNA

  1. XR_005505432.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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