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CTAG2 cancer/testis antigen 2 [ Homo sapiens (human) ]

Gene ID: 30848, updated on 23-Nov-2021

Summary

Official Symbol
CTAG2provided by HGNC
Official Full Name
cancer/testis antigen 2provided by HGNC
Primary source
HGNC:HGNC:2492
See related
Ensembl:ENSG00000126890 MIM:300396
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT2; ESO2; CAMEL; CT6.2; CT6.2a; CT6.2b; LAGE-1; LAGE2B
Summary
This gene encodes an autoimmunogenic tumor antigen that belongs to the ESO/LAGE family of cancer-testis antigens. This protein is expressed in a wide array of cancers including melanoma, breast cancer, bladder cancer and prostate cancer. This protein is also expressed in normal testis tissue. An alternative open reading frame product of this gene has been described in PMID:10399963. This alternate protein, termed CAMEL, is a tumor antigen that is recognized by melanoma-specific cytotoxic T-lymphocytes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Biased expression in testis (RPKM 2.5), placenta (RPKM 1.4) and 2 other tissues See more
Orthologs
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Genomic context

See CTAG2 in Genome Data Viewer
Location:
Xq28
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (154651977..154653579, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153880251..153881853, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene IKBKGP1 upstream recombination region Neighboring gene inhibitor of nuclear factor kappa B kinase subunit gamma pseudogene 1 Neighboring gene IKBKGP1 recombination region Neighboring gene uncharacterized LOC105373387 Neighboring gene olfactory receptor family 3 subfamily B member 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3803, MGC138724

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in tRNA threonylcarbamoyladenosine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
cancer/testis antigen 2
Names
CTL-recognized antigen on melanoma
LAGE-1a protein
autoimmunogenic cancer/testis antigen NY-ESO-2
cancer/testis antigen 6.2
cancer/testis antigen family 6, member 2a
cancer/testis antigen family 6, member 2b
l antigen family member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021275.2 RefSeqGene

    Range
    5001..6603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_020994.5NP_066274.2  cancer/testis antigen 2 isoform LAGE-1b

    See identical proteins and their annotated locations for NP_066274.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional segment in the 3' coding region which results in a frameshift, compared to variant 1. The encoded isoform (LAGE-1b, also known as LAGE-1L) is longer and has a distinct C-terminus, compared to isoform LAGE-1a.
    Source sequence(s)
    AJ223040, BC002833
    Consensus CDS
    CCDS14759.1
    UniProtKB/Swiss-Prot
    O75638
    Related
    ENSP00000247306.4, ENST00000247306.4
    Conserved Domains (1) summary
    pfam09341
    Location:90141
    Pcc1; Transcription factor Pcc1
  2. NM_172377.5NP_758965.2  cancer/testis antigen 2 isoform LAGE-1a

    See identical proteins and their annotated locations for NP_758965.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform LAGE-1a (also known as LAGE-1S).
    Source sequence(s)
    AJ223040, BC113998
    Consensus CDS
    CCDS35455.1
    UniProtKB/Swiss-Prot
    O75638
    Related
    ENSP00000358598.3, ENST00000369585.4
    Conserved Domains (1) summary
    pfam09341
    Location:90162
    Pcc1; Transcription factor Pcc1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    154651977..154653579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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