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EHD4 EH domain containing 4 [ Homo sapiens (human) ]

Gene ID: 30844, updated on 4-Jul-2021

Summary

Official Symbol
EHD4provided by HGNC
Official Full Name
EH domain containing 4provided by HGNC
Primary source
HGNC:HGNC:3245
See related
Ensembl:ENSG00000103966 MIM:605892
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAST4
Expression
Ubiquitous expression in urinary bladder (RPKM 15.6), gall bladder (RPKM 14.3) and 25 other tissues See more
Orthologs
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Genomic context

See EHD4 in Genome Data Viewer
Location:
15q15.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (41895933..41972557, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42188131..42264755, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 393 Neighboring gene spectrin beta, non-erythrocytic 5 Neighboring gene microRNA 4310 Neighboring gene uncharacterized LOC105370792 Neighboring gene Sharpr-MPRA regulatory region 4481 Neighboring gene EHD4 antisense RNA 1 Neighboring gene PLA2G4E antisense RNA 1 Neighboring gene phospholipase A2 group IVE Neighboring gene uncharacterized LOC105370793

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Knockdown of EHD4 by siRNA induces decreased levels of nef-deleted HIV-1 infectivity and decreases the ability of HIV-1 Nef to increase virus infectivity PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables cadherin binding HDA PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endocytic recycling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in pinocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein homooligomerization IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of endocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
located_in extracellular exosome HDA PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane HDA PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in recycling endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
EH domain-containing protein 4
Names
PAST homolog 4
hepatocellular carcinoma-associated protein 10/11
hepatocellular carcinoma-associated protein HCA11
ortholog of rat pincher

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139265.4NP_644670.1  EH domain-containing protein 4

    See identical proteins and their annotated locations for NP_644670.1

    Status: VALIDATED

    Source sequence(s)
    AC020659, AC039056, AK292634, BC051823, BP314075, CF541306
    Consensus CDS
    CCDS10081.1
    UniProtKB/Swiss-Prot
    Q9H223
    UniProtKB/TrEMBL
    A0A024R9N6, A8K9B9
    Related
    ENSP00000220325.4, ENST00000220325.9
    Conserved Domains (4) summary
    smart00027
    Location:441534
    EH; Eps15 homology domain
    cd09913
    Location:63303
    EHD; Eps15 homology domain (EHD), C-terminal domain
    cd00052
    Location:451515
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam16880
    Location:2759
    EHD_N; N-terminal EH-domain containing protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    41895933..41972557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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