Rtn2 reticulon 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rtn2provided by RGD
Official Full Name: reticulon 2provided by RGD
Primary source: RGD:1303245
See related: Ensembl:ENSRNOG00000016603 AllianceGenome:RGD:1303245
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NSPLI; RTN2-B
Summary: Acts upstream of or within protein transport. Located in cell surface and endoplasmic reticulum. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 12. Orthologous to human RTN2 (reticulon 2). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Muscle (RPKM 887.7), Heart (RPKM 137.2) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (88063124..88076082)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (78935056..78948069)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (80195594..80208449)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RTN2B functions as a positive regulator in the delivery of EAAC1 from the ER to the cell surface.
Title: Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1.

Submit: New GeneRIF Correction

General gene information

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Markers

Rtn2 (e-PCR), detects polymorphism
- UniSTS:256831

Rtn2 (e-PCR), detects polymorphism
- UniSTS:256832

Rtn2 (e-PCR), detects polymorphism
- UniSTS:256833

Rtn2 (e-PCR), detects polymorphism
- UniSTS:547530

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum tubular network formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum tubular network membrane organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular protein transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular protein transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular protein transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of amyloid-beta formation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid-beta formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of D-glucose import	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of D-glucose import	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in T-tubule	IEA Inferred from Electronic Annotation more info
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in T-tubule	ISS Inferred from Sequence or Structural Similarity more info
located_in Z disc	IEA Inferred from Electronic Annotation more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in Z disc	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
located_in intermediate filament	ISO Inferred from Sequence Orthology more info
located_in intermediate filament	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in terminal cisterna	IEA Inferred from Electronic Annotation more info
located_in terminal cisterna	ISO Inferred from Sequence Orthology more info
located_in terminal cisterna	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: reticulon-2

Names: NSP-like 1; NSP-like protein 1; NSP-like protein I; formerly RTN2w; neuroendocrine-specific protein-like 1; neuroendocrine-specific protein-like I; reticulon 2 (Z-band associated protein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.