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SOCS7 suppressor of cytokine signaling 7 [ Homo sapiens (human) ]

Gene ID: 30837, updated on 5-Jul-2020

Summary

Official Symbol
SOCS7provided by HGNC
Official Full Name
suppressor of cytokine signaling 7provided by HGNC
Primary source
HGNC:HGNC:29846
See related
Ensembl:ENSG00000274211 MIM:608788
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NAP4; NCKAP4
Expression
Broad expression in testis (RPKM 18.1), brain (RPKM 7.5) and 24 other tissues See more
Orthologs

Genomic context

See SOCS7 in Genome Data Viewer
Location:
17q12
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (38351844..38405593)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (36508007..36561846)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L45 Neighboring gene G protein-coupled receptor 179 Neighboring gene Sharpr-MPRA regulatory region 681 Neighboring gene Rho GTPase activating protein 23 Neighboring gene uncharacterized LOC101929494

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SH3 domain binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
regulation of phosphatidylinositol 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
suppressor of cytokine signaling 7
Names
NAP-4
NCK-associated protein 4
Nck, Ash and phospholipase C binding protein
SOCS-7
nck, Ash and phospholipase C gamma-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014598.4NP_055413.2  suppressor of cytokine signaling 7

    Status: VALIDATED

    Source sequence(s)
    AB005216, AC244092, AC244153, BC128607
    Consensus CDS
    CCDS32637.1
    Related
    ENSP00000482229.2, ENST00000612932.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    38351844..38405593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024551.1XP_016880040.1  suppressor of cytokine signaling 7 isoform X1

    Related
    ENSP00000484381.2, ENST00000613678.5
  2. XM_017024552.1XP_016880041.1  suppressor of cytokine signaling 7 isoform X2

RNA

  1. XR_001752503.1 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    2386792..2440912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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