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KCNIP2 potassium voltage-gated channel interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 30819, updated on 2-Mar-2021

Summary

Official Symbol
KCNIP2provided by HGNC
Official Full Name
potassium voltage-gated channel interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:15522
See related
Ensembl:ENSG00000120049 MIM:604661
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KCHIP2
Summary
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in fat (RPKM 117.8), heart (RPKM 37.5) and 1 other tissue See more
Orthologs
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Genomic context

See KCNIP2 in Genome Data Viewer
Location:
10q24.32
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (101825971..101843875, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103585731..103603557, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene nucleophosmin/nucleoplasmin 3 Neighboring gene O-GlcNAcase Neighboring gene KCNIP2 antisense RNA 1 Neighboring gene uncharacterized LOC107984029 Neighboring gene uncharacterized LOC101927445 Neighboring gene armadillo like helical domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC17241, DKFZp566L1246

Gene Ontology Provided by GOA

Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
potassium channel complex TAS
Traceable Author Statement
more info
PubMed 
synapse IEA
Inferred from Electronic Annotation
more info
 
voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
voltage-gated potassium channel complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
Kv channel-interacting protein 2
Names
A-type potassium channel modulatory protein 2
Kv channel interacting protein 2
cardiac voltage-gated potassium channel modulatory subunit
potassium channel-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029836.1 RefSeqGene

    Range
    5121..22947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014591.5NP_055406.2  Kv channel-interacting protein 2 isoform 1

    See identical proteins and their annotated locations for NP_055406.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as KChIP4.2, encodes the longest isoform (1).
    Source sequence(s)
    AF367018, AJ276317, AK094668, AL136722, BC034685
    Consensus CDS
    CCDS7521.1
    UniProtKB/Swiss-Prot
    Q9NS61
    UniProtKB/TrEMBL
    B3KSZ5
    Related
    ENSP00000420040.1, ENST00000461105.5
    Conserved Domains (1) summary
    COG5126
    Location:108274
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  2. NM_173191.3NP_775283.1  Kv channel-interacting protein 2 isoform 2

    See identical proteins and their annotated locations for NP_775283.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as KChIP2.4 or KChIP2L, lacks an in-frame segment in the coding region, as compared to variant 1. Isoform 2 is thus shorter than isoform 1.
    Source sequence(s)
    AF367021, AJ276317, AK094668, AL136722, BC034685
    Consensus CDS
    CCDS7522.1
    UniProtKB/Swiss-Prot
    Q9NS61
    UniProtKB/TrEMBL
    B3KSZ5
    Related
    ENSP00000349055.2, ENST00000356640.6
    Conserved Domains (1) summary
    COG5126
    Location:93259
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  3. NM_173192.3NP_775284.1  Kv channel-interacting protein 2 isoform 3

    See identical proteins and their annotated locations for NP_775284.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as KChIP2.1, lacks an in-frame segment in the coding region, as compared to variant 1. Isoform 3 is thus shorter than isoform 1.
    Source sequence(s)
    AJ276317, AK094668, AL136722, BC034685
    Consensus CDS
    CCDS41562.1
    UniProtKB/Swiss-Prot
    Q9NS61
    UniProtKB/TrEMBL
    B3KSZ5
    Related
    ENSP00000350733.3, ENST00000358038.7
    Conserved Domains (1) summary
    COG5126
    Location:75241
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  4. NM_173193.3NP_775285.1  Kv channel-interacting protein 2 isoform 4

    See identical proteins and their annotated locations for NP_775285.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as KChIP2S, lacks two consecutive in-frame segment and has an additional in-frame segment in the coding region, as compared to variant 1. Isoform 4 is shorter, but has the same N- and C-termini, as compared to isoform 1.
    Source sequence(s)
    AF295530, AJ276317, AK094668, AL136722, BC034685
    Consensus CDS
    CCDS7523.1
    UniProtKB/Swiss-Prot
    Q9NS61
    UniProtKB/TrEMBL
    B3KSZ5
    Related
    ENSP00000341624.3, ENST00000353068.7
    Conserved Domains (1) summary
    COG5126
    Location:43216
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  5. NM_173194.3NP_775286.1  Kv channel-interacting protein 2 isoform 5

    See identical proteins and their annotated locations for NP_775286.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has a shorter and alternate 5' sequence including the 5' UTR and the 5' coding region, as compared to variant 1. Isoform 5 is shorter and has a distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC010789, AJ276317, AL136722, BC034685
    Consensus CDS
    CCDS7525.1
    UniProtKB/Swiss-Prot
    Q9NS61
    Related
    ENSP00000239118.6, ENST00000348850.9
    Conserved Domains (1) summary
    COG5126
    Location:48214
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  6. NM_173195.3NP_775287.1  Kv channel-interacting protein 2 isoform 6

    See identical proteins and their annotated locations for NP_775287.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), also known as KChIP2.2, KChIP2T or KChIP2S, lacks two consecutive in-frame segments in the coding region, as compared to variant 1. It encodes a shorter isoform (6), that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AJ276317, AK094668, AL136722, BC034685
    Consensus CDS
    CCDS7524.1
    UniProtKB/Swiss-Prot
    Q9NS61
    UniProtKB/TrEMBL
    B3KSZ5
    Related
    ENSP00000344169.4, ENST00000343195.8
    Conserved Domains (1) summary
    COG5126
    Location:43209
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  7. NM_173197.3NP_775289.1  Kv channel-interacting protein 2 isoform 7

    See identical proteins and their annotated locations for NP_775289.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), also known as KChIP2.5, lacks four coding segments: two consecutive in the 5' region, one in the middle, and one at the 3' end, but has an alternate segment at the 3' end, as compared to variant 1. The alternate segment contains the stop codon. Therefore, isoform 7 has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AF367019, AK094668, BC034685
    Consensus CDS
    CCDS7526.1
    UniProtKB/Swiss-Prot
    Q9NS61
    UniProtKB/TrEMBL
    B3KSZ5
    Related
    ENSP00000239117.3, ENST00000239117.3
    Conserved Domains (1) summary
    cd00051
    Location:94165
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    101825971..101843875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269730.2XP_005269787.1  Kv channel-interacting protein 2 isoform X4

    Conserved Domains (2) summary
    COG5126
    Location:43201
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:130201
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. XM_005269729.2XP_005269786.1  Kv channel-interacting protein 2 isoform X3

    Conserved Domains (2) summary
    COG5126
    Location:75233
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:162233
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  3. XM_006717812.2XP_006717875.1  Kv channel-interacting protein 2 isoform X2

    Conserved Domains (2) summary
    COG5126
    Location:93251
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:180251
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  4. XM_011539731.2XP_011538033.1  Kv channel-interacting protein 2 isoform X1

    Conserved Domains (2) summary
    COG5126
    Location:48206
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:135206
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  5. XM_017016161.1XP_016871650.1  Kv channel-interacting protein 2 isoform X5

    Related
    ENSP00000495474.1, ENST00000642874.1
    Conserved Domains (1) summary
    COG5126
    Location:53219
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173342.2: Suppressed sequence

    Description
    NM_173342.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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