U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

KCNIP2 potassium voltage-gated channel interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 30819, updated on 10-Oct-2024

Summary

Official Symbol
KCNIP2provided by HGNC
Official Full Name
potassium voltage-gated channel interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:15522
See related
Ensembl:ENSG00000120049 MIM:604661; AllianceGenome:HGNC:15522
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KCHIP2
Summary
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in fat (RPKM 117.8), heart (RPKM 37.5) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See KCNIP2 in Genome Data Viewer
Location:
10q24.32
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (101825974..101843800, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (102709458..102727289, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (103585731..103603557, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene FGF8 5' regulatory region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103542131-103542770 Neighboring gene nucleophosmin/nucleoplasmin 3 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103577734-103578309 Neighboring gene O-GlcNAcase Neighboring gene Sharpr-MPRA regulatory region 4495 Neighboring gene KCNIP2 antisense RNA 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:103587343-103588542 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2729 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2730 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:103590597-103591113 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2731 Neighboring gene Sharpr-MPRA regulatory region 3638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103596213-103596713 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2733 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:103603069-103603574 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2734 Neighboring gene uncharacterized LOC101927445 Neighboring gene armadillo like helical domain containing 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3918 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:103662223-103662886 Neighboring gene uncharacterized LOC124902492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2735

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC17241, DKFZp566L1246

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to A-type (transient outward) potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ER retention sequence binding NAS
Non-traceable Author Statement
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables potassium channel regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables potassium channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in action potential IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chemical synaptic transmission NAS
Non-traceable Author Statement
more info
PubMed 
involved_in clustering of voltage-gated potassium channels IDA
Inferred from Direct Assay
more info
PubMed 
involved_in detection of calcium ion TAS
Traceable Author Statement
more info
PubMed 
involved_in membrane repolarization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in membrane repolarization during cardiac muscle cell action potential TAS
Traceable Author Statement
more info
PubMed 
involved_in muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in muscle contraction NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of potassium ion export across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of heart contraction NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of heart contraction TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of membrane repolarization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of potassium ion export across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of potassium ion export across plasma membrane TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of Kv4.2-KChIP2 channel complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of voltage-gated potassium channel complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of voltage-gated potassium channel complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
A-type potassium channel modulatory protein KCNIP2
Names
A-type potassium channel modulatory protein 2
Kv channel interacting protein 2
cardiac voltage-gated potassium channel modulatory subunit
potassium channel-interacting protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029836.1 RefSeqGene

    Range
    5121..22947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014591.5NP_055406.2  A-type potassium channel modulatory protein KCNIP2 isoform 1

    See identical proteins and their annotated locations for NP_055406.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as KChIP4.2, encodes the longest isoform (1).
    Source sequence(s)
    AF367018, AJ276317, AK094668, AL136722, BC034685
    Consensus CDS
    CCDS7521.1
    UniProtKB/TrEMBL
    B3KNV3
    Related
    ENSP00000420040.1, ENST00000461105.5
    Conserved Domains (1) summary
    COG5126
    Location:108274
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  2. NM_173191.3NP_775283.1  A-type potassium channel modulatory protein KCNIP2 isoform 2

    See identical proteins and their annotated locations for NP_775283.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as KChIP2.4 or KChIP2L, lacks an in-frame segment in the coding region, as compared to variant 1. Isoform 2 is thus shorter than isoform 1.
    Source sequence(s)
    AF367021, AJ276317, AK094668, AL136722, BC034685
    Consensus CDS
    CCDS7522.1
    UniProtKB/Swiss-Prot
    A6NJE5, A8MQ75, Q3YAC6, Q3YAC8, Q3YAC9, Q7Z6F1, Q96K86, Q96T41, Q96T42, Q96T43, Q96T44, Q9H0N4, Q9HD10, Q9HD11, Q9NS60, Q9NS61, Q9NY10, Q9NZI1
    UniProtKB/TrEMBL
    B3KNV3
    Related
    ENSP00000349055.2, ENST00000356640.7
    Conserved Domains (1) summary
    COG5126
    Location:93259
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  3. NM_173192.3NP_775284.1  A-type potassium channel modulatory protein KCNIP2 isoform 3

    See identical proteins and their annotated locations for NP_775284.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as KChIP2.1, lacks an in-frame segment in the coding region, as compared to variant 1. Isoform 3 is thus shorter than isoform 1.
    Source sequence(s)
    AJ276317, AK094668, AL136722, BC034685
    Consensus CDS
    CCDS41562.1
    UniProtKB/TrEMBL
    B3KNV3
    Related
    ENSP00000350733.3, ENST00000358038.7
    Conserved Domains (1) summary
    COG5126
    Location:75241
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  4. NM_173193.3NP_775285.1  A-type potassium channel modulatory protein KCNIP2 isoform 4

    See identical proteins and their annotated locations for NP_775285.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as KChIP2S, lacks two consecutive in-frame segment and has an additional in-frame segment in the coding region, as compared to variant 1. Isoform 4 is shorter, but has the same N- and C-termini, as compared to isoform 1.
    Source sequence(s)
    AF295530, AJ276317, AK094668, AL136722, BC034685
    Consensus CDS
    CCDS7523.1
    UniProtKB/TrEMBL
    Q09MK0
    Related
    ENSP00000341624.3, ENST00000353068.7
    Conserved Domains (1) summary
    COG5126
    Location:43216
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  5. NM_173194.3NP_775286.1  A-type potassium channel modulatory protein KCNIP2 isoform 5

    See identical proteins and their annotated locations for NP_775286.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has a shorter and alternate 5' sequence including the 5' UTR and the 5' coding region, as compared to variant 1. Isoform 5 is shorter and has a distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC010789, AJ276317, AL136722, BC034685
    Consensus CDS
    CCDS7525.1
    UniProtKB/TrEMBL
    B4DW99
    Related
    ENSP00000239118.6, ENST00000348850.9
    Conserved Domains (1) summary
    COG5126
    Location:48214
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  6. NM_173195.3NP_775287.1  A-type potassium channel modulatory protein KCNIP2 isoform 6

    See identical proteins and their annotated locations for NP_775287.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), also known as KChIP2.2, KChIP2T or KChIP2S, lacks two consecutive in-frame segments in the coding region, as compared to variant 1. It encodes a shorter isoform (6), that is missing an internal segment compared to isoform 1.
    Source sequence(s)
    AJ276317, AK094668, AL136722, BC034685
    Consensus CDS
    CCDS7524.1
    UniProtKB/TrEMBL
    Q09MK0
    Related
    ENSP00000344169.4, ENST00000343195.8
    Conserved Domains (1) summary
    COG5126
    Location:43209
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  7. NM_173197.3NP_775289.1  A-type potassium channel modulatory protein KCNIP2 isoform 7

    See identical proteins and their annotated locations for NP_775289.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), also known as KChIP2.5, lacks four coding segments: two consecutive in the 5' region, one in the middle, and one at the 3' end, but has an alternate segment at the 3' end, as compared to variant 1. The alternate segment contains the stop codon. Therefore, isoform 7 has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AF367019, AK094668, BC034685
    Consensus CDS
    CCDS7526.1
    UniProtKB/TrEMBL
    A6NFF4
    Related
    ENSP00000239117.3, ENST00000239117.3
    Conserved Domains (1) summary
    cd00051
    Location:94165
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    101825974..101843800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269730.3XP_005269787.1  A-type potassium channel modulatory protein KCNIP2 isoform X4

    UniProtKB/TrEMBL
    Q09MK0
    Conserved Domains (2) summary
    COG5126
    Location:43201
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:130201
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. XM_005269729.3XP_005269786.1  A-type potassium channel modulatory protein KCNIP2 isoform X3

    UniProtKB/TrEMBL
    B3KNV3
    Conserved Domains (2) summary
    COG5126
    Location:75233
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:162233
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  3. XM_006717812.3XP_006717875.1  A-type potassium channel modulatory protein KCNIP2 isoform X2

    UniProtKB/TrEMBL
    B3KNV3
    Conserved Domains (2) summary
    COG5126
    Location:93251
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:180251
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  4. XM_011539731.3XP_011538033.1  A-type potassium channel modulatory protein KCNIP2 isoform X1

    UniProtKB/TrEMBL
    B4DW99
    Conserved Domains (2) summary
    COG5126
    Location:48206
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00051
    Location:135206
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  5. XM_017016161.2XP_016871650.1  A-type potassium channel modulatory protein KCNIP2 isoform X5

    UniProtKB/TrEMBL
    A0A2R8Y6D7, Q09MK0
    Related
    ENSP00000495474.1, ENST00000642874.1
    Conserved Domains (1) summary
    COG5126
    Location:53219
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    102709458..102727289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365684.1XP_054221659.1  A-type potassium channel modulatory protein KCNIP2 isoform X4

  2. XM_054365683.1XP_054221658.1  A-type potassium channel modulatory protein KCNIP2 isoform X3

  3. XM_054365682.1XP_054221657.1  A-type potassium channel modulatory protein KCNIP2 isoform X2

  4. XM_054365681.1XP_054221656.1  A-type potassium channel modulatory protein KCNIP2 isoform X1

  5. XM_054365685.1XP_054221660.1  A-type potassium channel modulatory protein KCNIP2 isoform X5

    UniProtKB/TrEMBL
    A0A2R8Y6D7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173342.2: Suppressed sequence

    Description
    NM_173342.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.