Rgs17 regulator of G-protein signaling 17 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rgs17provided by RGD
Official Full Name: regulator of G-protein signaling 17provided by RGD
Primary source: RGD:1305515
See related: Ensembl:ENSRNOG00000018690 AllianceGenome:RGD:1305515
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Involved in response to amphetamine. Orthologous to human RGS17 (regulator of G protein signaling 17). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in Brain (RPKM 133.3), Heart (RPKM 12.6) and 1 other tissue See more
Orthologs: all
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Genomic context

Location:: 1q11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (44627583..44729957, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (42222248..42324625, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (42491566..42587735, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulator of G protein signaling 17 represents a novel target for treating cisplatin induced hearing loss.
Title: Regulator of G protein signaling 17 represents a novel target for treating cisplatin induced hearing loss.
RGS17 is differentially expressed in hepatocellular carcinoma cells and plays a central role in regulating transformed hepatocyte tumorgenicity.
Title: Altered expression and function of regulator of G-protein signaling-17 (RGS17) in hepatocellular carcinoma.

Submit: New GeneRIF Correction

General gene information

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Markers

RH132370 (e-PCR)
- UniSTS:215653

d1rat16 (e-PCR)
- UniSTS:121458

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to amphetamine	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: regulator of G-protein signaling 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107459.1 → NP_001100929.1 regulator of G-protein signaling 17

See identical proteins and their annotated locations for NP_001100929.1

Status: PROVISIONAL

Source sequence(s)

CH474052

UniProtKB/TrEMBL

A6KIP2, F1M0G0

Related

ENSRNOP00000025355.5, ENSRNOT00000025355.9

Conserved Domains (1) summary

cl02565
Location:41 → 197

RGS; Regulator of G protein signaling (RGS) domain superfamily
NM_001437799.1 → NP_001424728.1 regulator of G-protein signaling 17

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6KIP2, F1M0G0
NM_001437800.1 → NP_001424729.1 regulator of G-protein signaling 17

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6KIP2, F1M0G0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

44627583..44729957 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006227854.5 → XP_006227916.1

Conserved Domains (1) summary

cl02565
Location:41 → 197

RGS; Regulator of G protein signaling (RGS) domain superfamily
XM_006227855.5 → XP_006227917.1

Conserved Domains (1) summary

cl02565
Location:41 → 197

RGS; Regulator of G protein signaling (RGS) domain superfamily