U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HUNK hormonally up-regulated Neu-associated kinase [ Homo sapiens (human) ]

Gene ID: 30811, updated on 2-May-2024

Summary

Official Symbol
HUNKprovided by HGNC
Official Full Name
hormonally up-regulated Neu-associated kinaseprovided by HGNC
Primary source
HGNC:HGNC:13326
See related
Ensembl:ENSG00000142149 MIM:606532; AllianceGenome:HGNC:13326
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta (RPKM 1.4), colon (RPKM 1.2) and 20 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See HUNK in Genome Data Viewer
Location:
21q22.11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (31873020..32004064)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (30241343..30372246)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (33245333..33376377)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905008 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:33104777-33105416 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:33104135-33104776 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:33106899-33107074 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:33119263-33119514 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:33126139-33126731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18357 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33172518-33173018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33173019-33173519 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:33200433-33200620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13245 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13246 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33253321-33253821 Neighboring gene TPT1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33280341-33280874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33284969-33285779 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:33303660-33304223 Neighboring gene NANOG hESC enhancer GRCh37_chr21:33315105-33315606 Neighboring gene NANOG hESC enhancer GRCh37_chr21:33346858-33347382 Neighboring gene long intergenic non-protein coding RNA 159 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:33506465-33506966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18359 Neighboring gene MIS18 kinetochore protein A Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:33650609-33651110 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:33651111-33651610

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8.
EBI GWAS Catalog
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
EBI GWAS Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog
Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
hormonally up-regulated neu tumor-associated kinase
Names
B19
hormonally upregulated Neu-associated kinase
hormonally upregulated neu tumor-associated kinase
serine/threonine protein kinase MAK-V
NP_055401.1
XP_011527839.1
XP_054180424.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014586.2NP_055401.1  hormonally up-regulated neu tumor-associated kinase

    See identical proteins and their annotated locations for NP_055401.1

    Status: VALIDATED

    Source sequence(s)
    AJ271722, AP000256
    Consensus CDS
    CCDS13610.1
    UniProtKB/Swiss-Prot
    P57058
    Related
    ENSP00000270112.2, ENST00000270112.7
    Conserved Domains (2) summary
    smart00220
    Location:61320
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14070
    Location:58320
    STKc_HUNK; Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase (also called MAK-V)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    31873020..32004064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529537.3XP_011527839.1  hormonally up-regulated neu tumor-associated kinase isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:61320
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14070
    Location:58320
    STKc_HUNK; Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase (also called MAK-V)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    30241343..30372246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324449.1XP_054180424.1  hormonally up-regulated neu tumor-associated kinase isoform X1