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HUNK hormonally up-regulated Neu-associated kinase [ Homo sapiens (human) ]

Gene ID: 30811, updated on 5-Nov-2017
Official Symbol
HUNKprovided by HGNC
Official Full Name
hormonally up-regulated Neu-associated kinaseprovided by HGNC
Primary source
HGNC:HGNC:13326
See related
Ensembl:ENSG00000142149 MIM:606532; Vega:OTTHUMG00000085019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in placenta (RPKM 1.4), colon (RPKM 1.2) and 20 other tissues See more
Orthologs
Location:
21q22.11
Exon count:
11
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 21 NC_000021.9 (31873315..32004064)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (33245628..33376377)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene SR-related CTD associated factor 4 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 2 Neighboring gene tumor protein, translationally-controlled 1 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 159 Neighboring gene MIS18 kinetochore protein A

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8.
NHGRI GWA Catalog
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog
Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
hormonally up-regulated neu tumor-associated kinase
Names
B19
hormonally upregulated Neu-associated kinase
hormonally upregulated neu tumor-associated kinase
serine/threonine protein kinase MAK-V
NP_055401.1
XP_011527839.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014586.1NP_055401.1  hormonally up-regulated neu tumor-associated kinase

    See identical proteins and their annotated locations for NP_055401.1

    Status: VALIDATED

    Source sequence(s)
    AJ271722
    Consensus CDS
    CCDS13610.1
    UniProtKB/Swiss-Prot
    P57058
    Related
    ENSP00000270112.2, OTTHUMP00000107427, ENST00000270112.6, OTTHUMT00000192782
    Conserved Domains (2) summary
    smart00220
    Location:61320
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14070
    Location:58320
    STKc_HUNK; Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase (also called MAK-V)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p7 Primary Assembly

    Range
    31873315..32004064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529537.2XP_011527839.1  hormonally up-regulated neu tumor-associated kinase isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:61320
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14070
    Location:58320
    STKc_HUNK; Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase (also called MAK-V)

Alternate CHM1_1.1

Genomic

  1. NC_018932.2 Alternate CHM1_1.1

    Range
    32807370..32938097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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