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Map3k4 mitogen activated protein kinase kinase kinase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308106, updated on 18-Apr-2019

Summary

Official Symbol
Map3k4provided by RGD
Official Full Name
mitogen activated protein kinase kinase kinase 4provided by RGD
Primary source
RGD:1311192
See related
Ensembl:ENSRNOG00000017419
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Kidney (RPKM 104.1), Heart (RPKM 86.7) and 9 other tissues See more
Orthologs

Genomic context

See Map3k4 in Genome Data Viewer
Location:
1q11
Exon count:
27
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (48625714..48711642)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (51043920..51129819, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349106 Neighboring gene deoxyuridine triphosphatase pseudogene Neighboring gene uncharacterized LOC108349099 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 4 Neighboring gene uncharacterized LOC103690973 Neighboring gene parkin RBR E3 ubiquitin protein ligase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

  • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
  • G13 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    G13 Signaling Pathway, organism-specific biosystemThe G13 subunit is an alpha unit of heterotrimeric G proteins that regulates cell processes through the use of guanine nucleotide exchange factors. G13 regulates actin cytoskeletal remodeling in cell...
  • GnRH signaling pathway, organism-specific biosystem (from KEGG)
    GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
  • GnRH signaling pathway, conserved biosystem (from KEGG)
    GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
  • IL-6 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-6 Signaling Pathway, organism-specific biosystem
    IL-6 Signaling Pathway
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystem
    Insulin Signaling
  • MAPK (JNK) signaling, organism-specific biosystem (from KEGG)
    MAPK (JNK) signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • MAPK (JNK) signaling, conserved biosystem (from KEGG)
    MAPK (JNK) signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • MAPK (p38) signaling, organism-specific biosystem (from KEGG)
    MAPK (p38) signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • MAPK (p38) signaling, conserved biosystem (from KEGG)
    MAPK (p38) signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
activation of MAPKK activity IEA
Inferred from Electronic Annotation
more info
 
activation of MAPKK activity ISO
Inferred from Sequence Orthology
more info
PubMed 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
biological_process ND
No biological Data available
more info
 
chorionic trophoblast cell differentiation IEA
Inferred from Electronic Annotation
more info
 
chorionic trophoblast cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
male germ-line sex determination IEA
Inferred from Electronic Annotation
more info
 
male germ-line sex determination ISO
Inferred from Sequence Orthology
more info
PubMed 
placenta development IEA
Inferred from Electronic Annotation
more info
 
placenta development ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of JUN kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of p38MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of telomerase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of telomere capping IEA
Inferred from Electronic Annotation
more info
 
positive regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of telomere maintenance via telomerase IEA
Inferred from Electronic Annotation
more info
 
positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
response to UV-C IEA
Inferred from Electronic Annotation
more info
 
response to UV-C ISO
Inferred from Sequence Orthology
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase 4
NP_001100926.1
XP_006227934.1
XP_006227935.1
XP_006227936.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107456.1NP_001100926.1  mitogen-activated protein kinase kinase kinase 4

    See identical proteins and their annotated locations for NP_001100926.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474059
    UniProtKB/TrEMBL
    D3ZGU6
    Related
    ENSRNOP00000062453.1, ENSRNOT00000064018.3
    Conserved Domains (2) summary
    smart00220
    Location:11221380
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06626
    Location:11211380
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    48625714..48711642
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006227872.3XP_006227934.1  mitogen-activated protein kinase kinase kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K3R1
    Related
    ENSRNOP00000072741.1, ENSRNOT00000084317.1
    Conserved Domains (2) summary
    smart00220
    Location:13341592
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06626
    Location:13331592
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4
  2. XM_006227873.3XP_006227935.1  mitogen-activated protein kinase kinase kinase 4 isoform X2

    Conserved Domains (2) summary
    smart00220
    Location:12801538
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06626
    Location:12791538
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4
  3. XM_006227874.3XP_006227936.1  mitogen-activated protein kinase kinase kinase 4 isoform X3

    Conserved Domains (2) summary
    smart00220
    Location:12531511
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06626
    Location:12521511
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    44222636..44308690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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