Adamts8 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adamts8provided by MGI
Official Full Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8provided by MGI
Primary source: MGI:MGI:1353468
See related: Ensembl:ENSMUSG00000031994 AllianceGenome:MGI:1353468
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: METH2; METH-2
Summary: This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. This gene is expressed in mouse lung, heart and macrophage-rich areas of atherosclerotic plaques. The encoded preproprotein undergoes proteolytic processing to generate an active, zinc-dependent aggrecanase enzyme. This gene is located adjacent to a related ADAMTS gene on chromosome 9. [provided by RefSeq, May 2016]
Expression: Broad expression in lung adult (RPKM 4.1), limb E14.5 (RPKM 1.2) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A4; 9 16.49 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (30853858..30875134)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (30942562..30963838)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADAMTS8 deletion reduced pulmonary artery smooth muscle cell proliferation with AMPK up-regulation.
Title: ADAMTS8 Promotes the Development of Pulmonary Arterial Hypertension and Right Ventricular Failure: A Possible Novel Therapeutic Target.
This study demonstrated that Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8 in mice.
Title: Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin.
ADAMTS-4 expression was upregulated during the development of atherosclerosis in LDLR(-/-)ApoB(100/100) mice.
Title: ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

Adamts8 (e-PCR), detects polymorphism
- UniSTS:532655

Homology

Homologs of the Adamts8 gene: The Adamts8 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 333 organisms have orthologs with human gene Adamts8
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 8

Names: a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001326292.1 → NP_001313221.1 A disintegrin and metalloproteinase with thrombospondin motifs 8 isoform 2

Status: REVIEWED

Source sequence(s)

AK043875, CT025653
NM_013906.3 → NP_038934.2 A disintegrin and metalloproteinase with thrombospondin motifs 8 isoform 1 preproprotein

See identical proteins and their annotated locations for NP_038934.2

Status: REVIEWED

Source sequence(s)

AK043875, CT025653

Consensus CDS

CCDS22946.1

UniProtKB/TrEMBL

F8VQ15

Related

ENSMUSP00000069644.7, ENSMUST00000068135.13

Conserved Domains (6) summary

smart00209
Location:545 → 597

TSP1; Thrombospondin type 1 repeats

cd04273
Location:234 → 441

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:234 → 444

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:52 → 152

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:706 → 825

ADAM_spacer1; ADAM-TS Spacer 1

cl15456
Location:463 → 529

ADAM_CR; ADAM cysteine-rich