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Slc39a1 solute carrier family 39 (zinc transporter), member 1 [ Mus musculus (house mouse) ]

Gene ID: 30791, updated on 6-Jun-2024

Summary

Official Symbol
Slc39a1provided by MGI
Official Full Name
solute carrier family 39 (zinc transporter), member 1provided by MGI
Primary source
MGI:MGI:1353474
See related
Ensembl:ENSMUSG00000052310 AllianceGenome:MGI:1353474
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zip1; Zirtl
Summary
Enables zinc ion transmembrane transporter activity. Acts upstream of or within chordate embryonic development; limb development; and zinc ion transport. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human SLC39A1 (solute carrier family 39 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 59.1), colon adult (RPKM 46.3) and 28 other tissues See more
Orthologs
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Genomic context

See Slc39a1 in Genome Data Viewer
Location:
3 F1; 3 39.21 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (90155512..90160923)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90248190..90253613)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1624 Neighboring gene RAB13, member RAS oncogene family Neighboring gene jumping translocation breakpoint Neighboring gene cAMP responsive element binding protein 3-like 4 Neighboring gene STARR-positive B cell enhancer ABC_E1265 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:90052523-90052632 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:90057967-90058076 Neighboring gene CREB regulated transcription coactivator 2 Neighboring gene STARR-positive B cell enhancer ABC_E4558 Neighboring gene DENN domain containing 4B Neighboring gene microRNA 7012

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc transporter ZIP1
Names
ZIP-1
Zrt/Irt-like protein 1
mZIP1
solute carrier family 39 member 1
zrt- and Irt-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411505.1NP_001398434.1  zinc transporter ZIP1

    Status: VALIDATED

    Source sequence(s)
    AC119825
    UniProtKB/Swiss-Prot
    A2RTD4, Q99K44, Q9QZ03
    UniProtKB/TrEMBL
    Q3UK48
  2. NM_013901.3NP_038929.2  zinc transporter ZIP1

    See identical proteins and their annotated locations for NP_038929.2

    Status: VALIDATED

    Source sequence(s)
    AC119825
    Consensus CDS
    CCDS17525.1
    UniProtKB/Swiss-Prot
    A2RTD4, Q99K44, Q9QZ03
    UniProtKB/TrEMBL
    Q3UK48
    Related
    ENSMUSP00000076012.7, ENSMUST00000015467.9
    Conserved Domains (1) summary
    pfam02535
    Location:48319
    Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    90155512..90160923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)