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Ldhd lactate dehydrogenase D [ Rattus norvegicus (Norway rat) ]

Gene ID: 307858, updated on 30-Sep-2021

Summary

Official Symbol
Ldhdprovided by RGD
Official Full Name
lactate dehydrogenase Dprovided by RGD
Primary source
RGD:1308107
See related
EnsemblRapid:ENSRNOG00000019036
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ac2-202
Expression
Biased expression in Kidney (RPKM 369.1), Heart (RPKM 198.7) and 6 other tissues See more
Orthologs
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Genomic context

See Ldhd in Genome Data Viewer
Location:
19q12
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (39573621..39595575, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (43826989..43848937, complement)

Chromosome 19 - NC_051354.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 59 Neighboring gene 60S ribosomal protein L29-like Neighboring gene uncharacterized LOC120098630 Neighboring gene zinc and ring finger 1 Neighboring gene zinc finger protein 1 Neighboring gene chymotrypsinogen B1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables D-lactate dehydrogenase (cytochrome) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables D-lactate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables FAD binding IEA
Inferred from Electronic Annotation
more info
 
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in lactate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lactate catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
probable D-lactate dehydrogenase, mitochondrial
Names
D-lactate dehydrogenase
NP_001008893.1
XP_006255693.1
XP_038953698.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008893.2NP_001008893.1  probable D-lactate dehydrogenase, mitochondrial

    See identical proteins and their annotated locations for NP_001008893.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000313
    UniProtKB/TrEMBL
    Q7TPJ4
    Related
    ENSRNOP00000046399.1, ENSRNOT00000044844.3
    Conserved Domains (3) summary
    COG0277
    Location:46454
    GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    pfam01565
    Location:78214
    FAD_binding_4; FAD binding domain
    pfam02913
    Location:255455
    FAD-oxidase_C; FAD linked oxidases, C-terminal domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051354.1 Reference mRatBN7.2 Primary Assembly

    Range
    39573621..39595575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006255631.4XP_006255693.1  probable D-lactate dehydrogenase, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006255693.1

    UniProtKB/TrEMBL
    A0A0G2K1W9
    Related
    ENSRNOP00000072015.2, ENSRNOT00000079539.2
    Conserved Domains (1) summary
    PLN02805
    Location:19482
    PLN02805; D-lactate dehydrogenase [cytochrome]
  2. XM_039097770.1XP_038953698.1  probable D-lactate dehydrogenase, mitochondrial isoform X2

    Conserved Domains (1) summary
    PLN02805
    Location:1366
    PLN02805; D-lactate dehydrogenase [cytochrome]
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